PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29361418-1 2018 OBJECTIVE: To evaluate target engagement of intracisternally (IC) delivered TRPV1 agonist, resiniferatoxin (RTX), as measured by primary afferent and dorsal horn substance P immunoreactivity (sP-IR), histopathology and thermal escape latencies in dogs. resiniferatoxin 91-106 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 76-81 34259041-3 2021 Local cardiac and intrathecal administration of an ultra-potent noncompetitive, dominant negative agonist resiniferatoxin (RTX) can ablate these TRPV1 sensitive afferents. resiniferatoxin 106-121 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 145-150 34259041-3 2021 Local cardiac and intrathecal administration of an ultra-potent noncompetitive, dominant negative agonist resiniferatoxin (RTX) can ablate these TRPV1 sensitive afferents. resiniferatoxin 123-126 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 145-150 31600641-10 2019 RESULTS: TRPV-1 was highly expressed in the TH-expressing neurons and RTX injection significantly ablated TRPV-1/TH-positive neurons in LSG. resiniferatoxin 70-73 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 106-112 31600641-15 2019 RTX microinjection down-regulated significantly TRPV-1, NGF and c-fos expression in the LSG compared with the control group. resiniferatoxin 0-3 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 48-54 31600641-16 2019 CONCLUSION: Targeted ablation of TRPV-1/TH positive sympathetic neurons induced by RTX stellate microinjection could suppress ischemia-induced cardiac autonomic imbalances and cardiac electrophysiology instability to protect against AMI-induced VAs. resiniferatoxin 83-86 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 33-39 30015705-0 2018 Long-term pain relief in canine osteoarthritis by a single intra-articular injection of resiniferatoxin, a potent TRPV1 agonist. resiniferatoxin 88-103 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 114-119 30015705-2 2018 We report on a peripheral interventional approach that uses intra-articular injection of the ultrapotent TRPV1 agonist resiniferatoxin (RTX) to produce a selective long-term chemoinactivation of nociceptive primary afferent nerve endings for pain control in naturally occurring canine osteoarthritis. resiniferatoxin 119-134 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 105-110 30015705-2 2018 We report on a peripheral interventional approach that uses intra-articular injection of the ultrapotent TRPV1 agonist resiniferatoxin (RTX) to produce a selective long-term chemoinactivation of nociceptive primary afferent nerve endings for pain control in naturally occurring canine osteoarthritis. resiniferatoxin 136-139 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 105-110 29408808-3 2018 Resiniferatoxin (RTX) is a very potent and selective TRPV1 agonist and is a promising candidate for treating many types of pain. resiniferatoxin 0-15 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 53-58 29408808-3 2018 Resiniferatoxin (RTX) is a very potent and selective TRPV1 agonist and is a promising candidate for treating many types of pain. resiniferatoxin 17-20 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 53-58 29361418-1 2018 OBJECTIVE: To evaluate target engagement of intracisternally (IC) delivered TRPV1 agonist, resiniferatoxin (RTX), as measured by primary afferent and dorsal horn substance P immunoreactivity (sP-IR), histopathology and thermal escape latencies in dogs. resiniferatoxin 108-111 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 76-81 15925202-8 2005 GTTR uptake was enhanced by the TRPV1 agonists, resiniferatoxin and anandamide, in Ca2+-free media. resiniferatoxin 48-63 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 32-37 25659068-1 2015 Resiniferatoxin (RTX) is the most potent among all known endogenous and synthetic agonists for the transient receptor potential vanilloid 1 (TRPV1) receptor, which is a calcium-permeable nonselective cation channel, expressed on the peripheral and central terminals of small-diameter sensory neurons. resiniferatoxin 0-15 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 99-139 25659068-1 2015 Resiniferatoxin (RTX) is the most potent among all known endogenous and synthetic agonists for the transient receptor potential vanilloid 1 (TRPV1) receptor, which is a calcium-permeable nonselective cation channel, expressed on the peripheral and central terminals of small-diameter sensory neurons. resiniferatoxin 0-15 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 141-146 25659068-1 2015 Resiniferatoxin (RTX) is the most potent among all known endogenous and synthetic agonists for the transient receptor potential vanilloid 1 (TRPV1) receptor, which is a calcium-permeable nonselective cation channel, expressed on the peripheral and central terminals of small-diameter sensory neurons. resiniferatoxin 17-20 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 99-139 25659068-1 2015 Resiniferatoxin (RTX) is the most potent among all known endogenous and synthetic agonists for the transient receptor potential vanilloid 1 (TRPV1) receptor, which is a calcium-permeable nonselective cation channel, expressed on the peripheral and central terminals of small-diameter sensory neurons. resiniferatoxin 17-20 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 141-146 25659068-2 2015 Prolonged calcium influx induced by RTX causes cytotoxicity and death of only those sensory neurons that express the TRPV1 ion channel leading to selective targeting and permanent deletion of the TRPV1-expressing C-fiber neuronal cell bodies in the dorsal root ganglia. resiniferatoxin 36-39 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 117-122 25659068-2 2015 Prolonged calcium influx induced by RTX causes cytotoxicity and death of only those sensory neurons that express the TRPV1 ion channel leading to selective targeting and permanent deletion of the TRPV1-expressing C-fiber neuronal cell bodies in the dorsal root ganglia. resiniferatoxin 36-39 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 196-201 15878709-5 2005 Dog TRPV1 was activated by various known TRPV1 agonists in a concentration-dependent manner: Ag23 = resiniferatoxin > olvanil approximately arvanil > capsaicin > phorbol 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) > N-oleoyldopamine (OLDA). resiniferatoxin 100-115 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 4-9 15878709-5 2005 Dog TRPV1 was activated by various known TRPV1 agonists in a concentration-dependent manner: Ag23 = resiniferatoxin > olvanil approximately arvanil > capsaicin > phorbol 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) > N-oleoyldopamine (OLDA). resiniferatoxin 100-115 transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris 41-46