PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29271803-4 2018 METHODS: Resiniferatoxin was injected subcutaneously into rat hind paw several minutes before surgical incision to inactivate transient receptor potential cation channel, subfamily V, member 1-positive nerve terminals. resiniferatoxin 9-24 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 126-192 27794548-3 2017 We hypothesized that local injection of the TRPV1 agonist resiniferatoxin (RTX) would produce long-lasting analgesia in a rat model of pain associated with burn injury. resiniferatoxin 58-73 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 44-49 27794548-3 2017 We hypothesized that local injection of the TRPV1 agonist resiniferatoxin (RTX) would produce long-lasting analgesia in a rat model of pain associated with burn injury. resiniferatoxin 75-78 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 44-49 28831207-0 2017 Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior. resiniferatoxin 12-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 38-43 28066142-5 2017 Pretreatment with resiniferatoxin (RTX), which depletes capsaicin receptor protein in primary afferent fibers, did not alter the paradoxical anti-allodynic effects produced by the intracisternal injection of bicuculline. resiniferatoxin 35-38 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 56-74 28831207-9 2017 These results suggest that the involvement of TRPV1 in TNF-induced pain offers new TRPV1-based experimental therapeutic approaches and demonstrates the analgesic potential of RTX in inflammatory pain diseases. resiniferatoxin 175-178 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 46-51 28484490-2 2017 Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 55-60 28484490-2 2017 Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 104-109 28484490-2 2017 Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 55-60 28484490-2 2017 Resiniferatoxin (RTX) is an excitotoxin that activates TRPV1 at low concentrations and defunctionalizes TRPV1 at high concentrations. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 104-109 28831207-4 2017 We examined the effect of intrathecal administration of the ultrapotent TRPV1 agonist resiniferatoxin (RTX) on TNF-induced pain-associated behavior of rats using von Frey and hot plate behavioral testing. resiniferatoxin 86-101 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 72-77 28831207-4 2017 We examined the effect of intrathecal administration of the ultrapotent TRPV1 agonist resiniferatoxin (RTX) on TNF-induced pain-associated behavior of rats using von Frey and hot plate behavioral testing. resiniferatoxin 103-106 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 72-77 27329106-1 2016 BACKGROUND: Resiniferatoxin (RTX) is a potent analog of capsaicin and activates transient receptor potential (TRP) vanilloid type (TRPV) 1. resiniferatoxin 12-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 90-138 27177419-4 2016 Here we use biochemical and electrophysiological approaches to investigate the resiniferatoxin(RTx) binding site in TRPV1 and to explore the functional relationships between TRPV1 and TRPV2. resiniferatoxin 79-94 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 116-121 27177419-4 2016 Here we use biochemical and electrophysiological approaches to investigate the resiniferatoxin(RTx) binding site in TRPV1 and to explore the functional relationships between TRPV1 and TRPV2. resiniferatoxin 95-98 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 116-121 27177419-6 2016 Moreover, we show that sensitivity to RTx can be engineered into TRPV2, demonstrating that the gating and permeation properties of this channel are similar to TRPV1. resiniferatoxin 38-41 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 159-164 27559176-6 2016 Activation of TRPV1 with either the selective agonist resiniferatoxin (150 pm) or temperature augmented basal sEPSC rates but failed to alter the synchronous or asynchronous modes of release. resiniferatoxin 54-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-19 27329106-1 2016 BACKGROUND: Resiniferatoxin (RTX) is a potent analog of capsaicin and activates transient receptor potential (TRP) vanilloid type (TRPV) 1. resiniferatoxin 29-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 90-138 26204493-8 2015 In CMG, the poreless TRPV1 vector-treated group showed a significantly smaller reduction in intercontraction intervals and voided volume after RTx infusion than the vHG-treated control group. resiniferatoxin 143-146 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 21-26 26807032-1 2016 This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a rat model of osteoarthritis (OA). resiniferatoxin 147-162 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 80-120 26807032-1 2016 This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a rat model of osteoarthritis (OA). resiniferatoxin 147-162 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 122-127 26807032-1 2016 This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a rat model of osteoarthritis (OA). resiniferatoxin 164-167 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 80-120 26807032-1 2016 This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a rat model of osteoarthritis (OA). resiniferatoxin 164-167 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 122-127 22820265-8 2012 Besides, the pretreatment with resiniferatoxin (RTX), a potent TRPV1 agonist, abolished the cinnamaldehyde-induced heat hyperalgesia. resiniferatoxin 31-46 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 63-68 25411361-6 2015 Prolonged desensitization of transient receptor potential vanilloid 1 (TRPV1)-expressing colonic afferents by resiniferatoxin (RTX) suppressed the spontaneous activity, as well as the anxiety- and depressive-like behaviors. resiniferatoxin 110-125 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 29-69 25411361-6 2015 Prolonged desensitization of transient receptor potential vanilloid 1 (TRPV1)-expressing colonic afferents by resiniferatoxin (RTX) suppressed the spontaneous activity, as well as the anxiety- and depressive-like behaviors. resiniferatoxin 110-125 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 71-76 25411361-6 2015 Prolonged desensitization of transient receptor potential vanilloid 1 (TRPV1)-expressing colonic afferents by resiniferatoxin (RTX) suppressed the spontaneous activity, as well as the anxiety- and depressive-like behaviors. resiniferatoxin 127-130 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 29-69 25411361-6 2015 Prolonged desensitization of transient receptor potential vanilloid 1 (TRPV1)-expressing colonic afferents by resiniferatoxin (RTX) suppressed the spontaneous activity, as well as the anxiety- and depressive-like behaviors. resiniferatoxin 127-130 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 71-76 24434730-5 2014 The ultrapotent TRPV1 agonist resiniferatoxin (RTX) dose-dependently deactivates TRPV1+ fibers and blocks thermal nociceptive responses in baseline or inflamed conditions. resiniferatoxin 30-45 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 16-21 24434730-5 2014 The ultrapotent TRPV1 agonist resiniferatoxin (RTX) dose-dependently deactivates TRPV1+ fibers and blocks thermal nociceptive responses in baseline or inflamed conditions. resiniferatoxin 30-45 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 81-86 24434730-5 2014 The ultrapotent TRPV1 agonist resiniferatoxin (RTX) dose-dependently deactivates TRPV1+ fibers and blocks thermal nociceptive responses in baseline or inflamed conditions. resiniferatoxin 47-50 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 16-21 24434730-5 2014 The ultrapotent TRPV1 agonist resiniferatoxin (RTX) dose-dependently deactivates TRPV1+ fibers and blocks thermal nociceptive responses in baseline or inflamed conditions. resiniferatoxin 47-50 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 81-86 23911956-7 2013 Moreover, nociception induced by either capsaicin or AITC was reduced by the desensitisation of TRPV1-positive sensory fibres with resiniferatoxin (73 +- 18 and 76 +- 15% inhibitions, respectively) and by the NK1 receptor antagonist aprepitant (56 +- 5 and 53 +- 8% inhibitions, respectively). resiniferatoxin 131-146 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-101 23639808-6 2013 In rats, blocking TRPV1 by capsazepine or TRPM5 by triphenylphosphine oxide inhibited the tonic NaCl + Bz CT response and shifted the relationship between RTX concentration and the magnitude of the tonic CT response to higher RTX concentrations. resiniferatoxin 155-158 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 18-23 23551937-3 2013 Systemic injection of resiniferatoxin (RTX), an ultrapotent analog of TRPV1 agonist, in adult rats can reproduce the clinical symptoms of PHN by ablating TRPV1-expressing sensory neurons. resiniferatoxin 22-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 70-75 23551937-3 2013 Systemic injection of resiniferatoxin (RTX), an ultrapotent analog of TRPV1 agonist, in adult rats can reproduce the clinical symptoms of PHN by ablating TRPV1-expressing sensory neurons. resiniferatoxin 22-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 154-159 23551937-3 2013 Systemic injection of resiniferatoxin (RTX), an ultrapotent analog of TRPV1 agonist, in adult rats can reproduce the clinical symptoms of PHN by ablating TRPV1-expressing sensory neurons. resiniferatoxin 39-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 70-75 23551937-3 2013 Systemic injection of resiniferatoxin (RTX), an ultrapotent analog of TRPV1 agonist, in adult rats can reproduce the clinical symptoms of PHN by ablating TRPV1-expressing sensory neurons. resiniferatoxin 39-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 154-159 23551937-12 2013 EA treatment at 2 and 15 Hz recovered the loss of TRPV1-positive dorsal root ganglion neurons and their central terminals of afferent fibers in the spinal superficial dorsal horn of RTX-treated rats. resiniferatoxin 182-185 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 50-55 25899631-1 2015 Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subtype 1) agonist with significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to thermal stimulus. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 50-55 25899631-1 2015 Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subtype 1) agonist with significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to thermal stimulus. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-105 25899631-1 2015 Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subtype 1) agonist with significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to thermal stimulus. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 50-55 25899631-1 2015 Resiniferatoxin (RTX) is an ultrapotent synthetic TRPV1 (transient receptor potential vanilloid subtype 1) agonist with significant initial transient hyperalgesia followed by a prolonged analgesic effect in response to thermal stimulus. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-105 23981530-0 2013 The carbonate analogues of 5"-halogenated resiniferatoxin as TRPV1 ligands. resiniferatoxin 42-57 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 61-66 23615109-1 2013 BACKGROUND: Resiniferatoxin (RTX), an excitotoxic agonist for vanilloid receptor 1, is a promising candidate for intractable pain treatment. resiniferatoxin 12-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 62-82 23615109-1 2013 BACKGROUND: Resiniferatoxin (RTX), an excitotoxic agonist for vanilloid receptor 1, is a promising candidate for intractable pain treatment. resiniferatoxin 29-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 62-82 22528458-1 2012 Pretreatment with the ultrapotent capsaicin analog resiniferatoxin (RTX) has been applied as a selective pharmacological tool in inflammation and pain studies to desensitize transient receptor potential vanilloid 1 (TRPV1) receptor-expressing sensory nerve endings. resiniferatoxin 51-66 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 174-214 22528458-1 2012 Pretreatment with the ultrapotent capsaicin analog resiniferatoxin (RTX) has been applied as a selective pharmacological tool in inflammation and pain studies to desensitize transient receptor potential vanilloid 1 (TRPV1) receptor-expressing sensory nerve endings. resiniferatoxin 51-66 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 216-221 22528458-1 2012 Pretreatment with the ultrapotent capsaicin analog resiniferatoxin (RTX) has been applied as a selective pharmacological tool in inflammation and pain studies to desensitize transient receptor potential vanilloid 1 (TRPV1) receptor-expressing sensory nerve endings. resiniferatoxin 68-71 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 174-214 22528458-1 2012 Pretreatment with the ultrapotent capsaicin analog resiniferatoxin (RTX) has been applied as a selective pharmacological tool in inflammation and pain studies to desensitize transient receptor potential vanilloid 1 (TRPV1) receptor-expressing sensory nerve endings. resiniferatoxin 68-71 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 216-221 22820265-8 2012 Besides, the pretreatment with resiniferatoxin (RTX), a potent TRPV1 agonist, abolished the cinnamaldehyde-induced heat hyperalgesia. resiniferatoxin 48-51 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 63-68 22820265-9 2012 Here, we showed that intrathecal RTX results in a decrease in TRPA1 and TRPV1 immunoreactivity in dorsal root ganglion. resiniferatoxin 33-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 72-77 22679016-8 2012 The reduction in postsynaptic NMDAR currents caused by morphine was prevented by resiniferatoxin pretreatment to ablate TRPV1-expressing primary afferents. resiniferatoxin 81-96 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 120-125 22588258-3 2012 JTS-653 displaced [(3)H]resiniferatoxin binding to human and rat TRPV1. resiniferatoxin 24-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 65-70 21680254-1 2011 UNLABELLED: Resiniferatoxin (RTX) is a potent agonist of TRPV1, which possesses unique properties that can be utilized to treat certain modalities of pain. resiniferatoxin 12-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-62 22828682-1 2012 BACKGROUND: Resiniferatoxin (RTX) is a potent synthetic agonist for transient receptor potential vanilloid subtype 1 (TRPV1), which has a selectivity for antinociception. resiniferatoxin 12-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-116 22828682-1 2012 BACKGROUND: Resiniferatoxin (RTX) is a potent synthetic agonist for transient receptor potential vanilloid subtype 1 (TRPV1), which has a selectivity for antinociception. resiniferatoxin 12-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 118-123 22828682-1 2012 BACKGROUND: Resiniferatoxin (RTX) is a potent synthetic agonist for transient receptor potential vanilloid subtype 1 (TRPV1), which has a selectivity for antinociception. resiniferatoxin 29-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-116 22828682-1 2012 BACKGROUND: Resiniferatoxin (RTX) is a potent synthetic agonist for transient receptor potential vanilloid subtype 1 (TRPV1), which has a selectivity for antinociception. resiniferatoxin 29-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 118-123 22546668-1 2012 The structure-activity relationships of N-(3-acyloxy-2-benzylpropyl)-N"-4-[(methylsulfonylamino)benzyl] thioureas, which represent simplified RTX-based vanilloids, were investigated by varying the distances between the four principal pharmacophores and assessing binding and antagonistic activity on rTRPV1. resiniferatoxin 142-145 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 300-306 22168801-6 2012 Transient receptor potential vanilloid 1 expressing neurons were selectively lesioned with resiniferatoxin. resiniferatoxin 91-106 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-40 22168801-9 2012 The PAR-2 agonist enhancement of colonic contraction was eliminated when TRPV1 expressing neurons were lesioned with resiniferatoxin, but the PAR-2 agonist induced hypersensitivity remained in the lesioned animals. resiniferatoxin 117-132 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 73-78 21680254-1 2011 UNLABELLED: Resiniferatoxin (RTX) is a potent agonist of TRPV1, which possesses unique properties that can be utilized to treat certain modalities of pain. resiniferatoxin 29-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-62 21680254-7 2011 administration of RTX prevented TRPV1-induced nocifensive behavior and inflammatory thermal hypersensitivity. resiniferatoxin 18-21 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 32-37 21680254-27 2011 PERSPECTIVE: Localized administration of RTX in spinal cord could be a useful strategy to treat chronic debilitating pain arising from certain conditions such as cancer and at the same time could maintain normal physiological peripheral efferent functions mediated by TRPV1. resiniferatoxin 41-44 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 268-273 20452292-3 2010 Resiniferatoxin (RTX) is an excitotoxic agonist of the vanilloid receptor 1 (VR1), a cation channel protein considered an integrator for nociception. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 55-75 21448716-4 2011 We experimentally evaluated by mutational analysis the contribution of residues of rTRPV1 contributing to ligand binding by the prototypical TRPV1 agonists, capsaicin and resiniferatoxin (RTX). resiniferatoxin 171-186 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-89 21448716-4 2011 We experimentally evaluated by mutational analysis the contribution of residues of rTRPV1 contributing to ligand binding by the prototypical TRPV1 agonists, capsaicin and resiniferatoxin (RTX). resiniferatoxin 171-186 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 84-89 21448716-4 2011 We experimentally evaluated by mutational analysis the contribution of residues of rTRPV1 contributing to ligand binding by the prototypical TRPV1 agonists, capsaicin and resiniferatoxin (RTX). resiniferatoxin 188-191 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-89 21448716-4 2011 We experimentally evaluated by mutational analysis the contribution of residues of rTRPV1 contributing to ligand binding by the prototypical TRPV1 agonists, capsaicin and resiniferatoxin (RTX). resiniferatoxin 188-191 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 84-89 21448716-7 2011 Additionally, the binding mode of a simplified RTX (sRTX) ligand as predicted by the modeling agreed well with those of capsaicin and RTX, accounting for the high binding affinity of the sRTX ligand for TRPV1. resiniferatoxin 47-50 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 203-208 21167052-1 2010 BACKGROUND: Ablation of TRPV1-expressing nociceptive fibers with the potent capsaicin analog resiniferatoxin (RTX) results in long lasting pain relief. resiniferatoxin 93-108 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-29 21167052-1 2010 BACKGROUND: Ablation of TRPV1-expressing nociceptive fibers with the potent capsaicin analog resiniferatoxin (RTX) results in long lasting pain relief. resiniferatoxin 110-113 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-29 21794120-8 2011 Intrathecal administration of resiniferatoxin (RTX), a potent TRPV1 agonist, significantly attenuated STZ-induced thermal hyperalgesia, but not mechanical allodynia. resiniferatoxin 30-45 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 62-67 21794120-8 2011 Intrathecal administration of resiniferatoxin (RTX), a potent TRPV1 agonist, significantly attenuated STZ-induced thermal hyperalgesia, but not mechanical allodynia. resiniferatoxin 47-50 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 62-67 21794120-9 2011 RTX treatment also prevented the increase in TRPV1-mediated neuropeptide release in the spinal cord tissue. resiniferatoxin 0-3 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 45-50 21794120-10 2011 CONCLUSIONS: From these results, it is concluded that TRPV1 is an integral component of initiating and maintaining inflammatory thermal hyperalgesia, which can be alleviated by intrathecal administration of RTX. resiniferatoxin 207-210 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 54-59 21098091-4 2011 AS1928370 bound to the resiniferatoxin-binding site on TRPV1 and inhibited capsaicin-mediated inward currents with an IC50 value of 32.5 nM. resiniferatoxin 23-38 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 55-60 21219650-8 2011 Pretreatment with resiniferatoxin (RTX), an ultrapotent capsaicin analogue known to produce long-lasting desensitization of TRPV1 positive afferents, fully blocked CFA-induced thermal hypersensitivity and abolished the CPP elicited by administration of popliteal fossa lidocaine 24 hrs post-CFA. resiniferatoxin 18-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 124-129 21219650-8 2011 Pretreatment with resiniferatoxin (RTX), an ultrapotent capsaicin analogue known to produce long-lasting desensitization of TRPV1 positive afferents, fully blocked CFA-induced thermal hypersensitivity and abolished the CPP elicited by administration of popliteal fossa lidocaine 24 hrs post-CFA. resiniferatoxin 35-38 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 124-129 21111618-0 2011 Receptor activity and conformational analysis of 5"-halogenated resiniferatoxin analogs as TRPV1 ligands. resiniferatoxin 64-79 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 91-96 20452292-3 2010 Resiniferatoxin (RTX) is an excitotoxic agonist of the vanilloid receptor 1 (VR1), a cation channel protein considered an integrator for nociception. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 77-80 20452292-3 2010 Resiniferatoxin (RTX) is an excitotoxic agonist of the vanilloid receptor 1 (VR1), a cation channel protein considered an integrator for nociception. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 55-75 20452292-3 2010 Resiniferatoxin (RTX) is an excitotoxic agonist of the vanilloid receptor 1 (VR1), a cation channel protein considered an integrator for nociception. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 77-80 20452292-4 2010 Resiniferatoxin, administered into the dorsal root ganglia (DRG), selectively eliminates the VR1-positive neurons and improves tactile allodynia in a neuropathic pain rat model. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 93-96 19800272-0 2010 Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin, resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat. resiniferatoxin 76-91 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-46 20403666-0 2010 Prolonged analgesic response of cornea to topical resiniferatoxin, a potent TRPV1 agonist. resiniferatoxin 50-65 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 76-81 20403666-3 2010 Resiniferatoxin (RTX), a potent TRPV1 agonist, produces transient analgesia when injected peripherally by inactivating TRPV1-expressing nerve terminals through excessive calcium influx. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 32-37 20403666-3 2010 Resiniferatoxin (RTX), a potent TRPV1 agonist, produces transient analgesia when injected peripherally by inactivating TRPV1-expressing nerve terminals through excessive calcium influx. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 119-124 20403666-3 2010 Resiniferatoxin (RTX), a potent TRPV1 agonist, produces transient analgesia when injected peripherally by inactivating TRPV1-expressing nerve terminals through excessive calcium influx. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 32-37 20403666-3 2010 Resiniferatoxin (RTX), a potent TRPV1 agonist, produces transient analgesia when injected peripherally by inactivating TRPV1-expressing nerve terminals through excessive calcium influx. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 119-124 19800272-7 2010 In conclusion, using measurement of threshold temperatures eliciting nocifensive reactions in rats both in the hot and cold range revealed that capsaicin and RTX impair thermosensation in both noxious ranges due to a functional desensitization of peripheral terminals of TRPV1-expressing sensory neurons responsible for noxious heat and cold responsiveness. resiniferatoxin 158-161 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 271-276 19800272-8 2010 This could be differentiated from desensitization of TRPV1 receptor evoked by lower doses of resiniferatoxin or N-oleoyldopamine. resiniferatoxin 93-108 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 53-58 19926130-3 2010 Pretreatment with SP or HK-1 enhanced the induction of scratching behavior by resiniferatoxin, a TRPV1 agonist, whereas scratching behavior induced by menthol, a TRPM8 agonist, was suppressed by pretreatment with these peptides. resiniferatoxin 78-93 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 97-102 19772627-5 2009 To determine whether spontaneous activity from C- or A-fibers is required for microglial activation, we used resiniferatoxin (RTX) to block the conduction of transient receptor potential vanilloid subtype 1 (TRPV1) positive fibers (mostly C- and Adelta-fibers) and bupivacaine microspheres to block all fibers of the sciatic nerve in rats before spared nerve injury (SNI), and observed spinal microglial changes 2 days later. resiniferatoxin 109-124 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 158-206 19726694-4 2009 Resiniferatoxin (RTX), an ultrapotent analog of capsaicin, was used to ablate TRPV1-expressing afferent neurons and fibers in adult rats. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 78-83 19726694-4 2009 Resiniferatoxin (RTX), an ultrapotent analog of capsaicin, was used to ablate TRPV1-expressing afferent neurons and fibers in adult rats. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 78-83 19726694-6 2009 RTX treatment eliminated TRPV1 immunoreactivities in the aorta, nodose ganglion, and solitary tract. resiniferatoxin 0-3 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 25-30 20383340-6 2010 The results indicate that CAP and high concentrations of RTX are more neurotoxic to cultured rat DRG neurons while the inability of the neurons to express SP or TRPV1 after acute exposure to the lower concentration of RTX could be partially reversed after a period of incubation. resiniferatoxin 218-221 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 161-166 19778582-2 2009 Resiniferatoxin (RTX) has a much higher affinity for TRPV1 than capsaicin, but its ability to modulate excitatory transmission is unclear. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 53-58 19778582-2 2009 Resiniferatoxin (RTX) has a much higher affinity for TRPV1 than capsaicin, but its ability to modulate excitatory transmission is unclear. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 53-58 19778582-9 2009 RTX enhances the spontaneous release of L-glutamate from nerve terminals with similar efficacy as capsaicin and produces a membrane depolarization by activating TRPV1 in the SG, with fast desensitization and slow recovery from desensitization. resiniferatoxin 0-3 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 161-166 19772627-5 2009 To determine whether spontaneous activity from C- or A-fibers is required for microglial activation, we used resiniferatoxin (RTX) to block the conduction of transient receptor potential vanilloid subtype 1 (TRPV1) positive fibers (mostly C- and Adelta-fibers) and bupivacaine microspheres to block all fibers of the sciatic nerve in rats before spared nerve injury (SNI), and observed spinal microglial changes 2 days later. resiniferatoxin 109-124 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 208-213 19772627-5 2009 To determine whether spontaneous activity from C- or A-fibers is required for microglial activation, we used resiniferatoxin (RTX) to block the conduction of transient receptor potential vanilloid subtype 1 (TRPV1) positive fibers (mostly C- and Adelta-fibers) and bupivacaine microspheres to block all fibers of the sciatic nerve in rats before spared nerve injury (SNI), and observed spinal microglial changes 2 days later. resiniferatoxin 126-129 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 158-206 19772627-5 2009 To determine whether spontaneous activity from C- or A-fibers is required for microglial activation, we used resiniferatoxin (RTX) to block the conduction of transient receptor potential vanilloid subtype 1 (TRPV1) positive fibers (mostly C- and Adelta-fibers) and bupivacaine microspheres to block all fibers of the sciatic nerve in rats before spared nerve injury (SNI), and observed spinal microglial changes 2 days later. resiniferatoxin 126-129 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 208-213 19753113-2 2009 Resiniferatoxin (RTX), a potent agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), causes a slow, sustained and irreversible activation of TRPV1 and increases the frequency of spontaneous excitatory postsynaptic currents, but causes significant depression of evoked EPSCs due to nerve terminal depolarization block. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 43-83 19753113-2 2009 Resiniferatoxin (RTX), a potent agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), causes a slow, sustained and irreversible activation of TRPV1 and increases the frequency of spontaneous excitatory postsynaptic currents, but causes significant depression of evoked EPSCs due to nerve terminal depolarization block. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 85-90 19753113-2 2009 Resiniferatoxin (RTX), a potent agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), causes a slow, sustained and irreversible activation of TRPV1 and increases the frequency of spontaneous excitatory postsynaptic currents, but causes significant depression of evoked EPSCs due to nerve terminal depolarization block. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 149-154 19753113-2 2009 Resiniferatoxin (RTX), a potent agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), causes a slow, sustained and irreversible activation of TRPV1 and increases the frequency of spontaneous excitatory postsynaptic currents, but causes significant depression of evoked EPSCs due to nerve terminal depolarization block. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 43-83 19753113-2 2009 Resiniferatoxin (RTX), a potent agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), causes a slow, sustained and irreversible activation of TRPV1 and increases the frequency of spontaneous excitatory postsynaptic currents, but causes significant depression of evoked EPSCs due to nerve terminal depolarization block. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 85-90 19753113-2 2009 Resiniferatoxin (RTX), a potent agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), causes a slow, sustained and irreversible activation of TRPV1 and increases the frequency of spontaneous excitatory postsynaptic currents, but causes significant depression of evoked EPSCs due to nerve terminal depolarization block. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 149-154 19753113-3 2009 Intrathecal administration of RTX to rats in the short-term inhibits nociceptive synaptic transmission, and in the long-term causes a localized, selective ablation of TRPV1-expressing central sensory nerve terminals leading to long lasting analgesia in behavioral models. resiniferatoxin 30-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 167-172 19236852-11 2009 Disruption of abdominal TRPV1 receptor function by injection of the TRPV1 receptor agonist, resiniferatoxin (20 microg/kg, i.p. resiniferatoxin 92-107 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-29 19236852-11 2009 Disruption of abdominal TRPV1 receptor function by injection of the TRPV1 receptor agonist, resiniferatoxin (20 microg/kg, i.p. resiniferatoxin 92-107 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-73 19147859-2 2009 We demonstrated recently that the preischemic treatment with resiniferatoxin, a transient receptor potential vanilloid 1 (TRPV1) agonist, attenuates renal TNF-alpha mRNA expression and improves ischemia/reperfusion-induced renal injury in rats. resiniferatoxin 61-76 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 80-120 19147859-2 2009 We demonstrated recently that the preischemic treatment with resiniferatoxin, a transient receptor potential vanilloid 1 (TRPV1) agonist, attenuates renal TNF-alpha mRNA expression and improves ischemia/reperfusion-induced renal injury in rats. resiniferatoxin 61-76 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 122-127 18824169-0 2008 Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals. resiniferatoxin 24-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 101-106 19012737-5 2009 Resiniferatoxin (RTX) treatment or dorsal rhizotomy ablated TRPV1-expressing primary afferents but did not affect TRPV1- and vesicular glutamate transporter-2-expressing dorsal horn neurons. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 60-65 19012737-5 2009 Resiniferatoxin (RTX) treatment or dorsal rhizotomy ablated TRPV1-expressing primary afferents but did not affect TRPV1- and vesicular glutamate transporter-2-expressing dorsal horn neurons. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 60-65 18824169-0 2008 Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals. resiniferatoxin 41-44 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 101-106 18824169-9 2008 Overall, our results show that intrathecal administration of RTX effectively reduces detrusor overactivity and reduces intravesical pressure in models of complete chronic spinal cord transection by suppressing the activity of TRPV1 expressing afferent fibres. resiniferatoxin 61-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 226-231 19085565-2 2008 Transient receptor potential vanilloid-1 (TRPV1) is an ion channel activated by the tussive agents capsaicin, resiniferatoxin, and protons. resiniferatoxin 110-125 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-40 19085565-2 2008 Transient receptor potential vanilloid-1 (TRPV1) is an ion channel activated by the tussive agents capsaicin, resiniferatoxin, and protons. resiniferatoxin 110-125 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 42-47 18669865-4 2008 Treatment with the ultrapotent TRPV1 agonist resiniferotoxin (RTX) eliminated TRPV1-expressing dorsal root ganglion neurons and their central terminals in the spinal dorsal horn and significantly reduced the basal amplitude of glutamatergic excitatory postsynaptic currents (EPSCs) evoked from primary afferents. resiniferatoxin 62-65 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 31-36 18625695-5 2008 Resiniferatoxin (RTX) is a TRPV1 agonist that, in high doses, defunctionalises C and Adelta fibres. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 27-32 18625695-5 2008 Resiniferatoxin (RTX) is a TRPV1 agonist that, in high doses, defunctionalises C and Adelta fibres. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 27-32 18669865-4 2008 Treatment with the ultrapotent TRPV1 agonist resiniferotoxin (RTX) eliminated TRPV1-expressing dorsal root ganglion neurons and their central terminals in the spinal dorsal horn and significantly reduced the basal amplitude of glutamatergic excitatory postsynaptic currents (EPSCs) evoked from primary afferents. resiniferatoxin 62-65 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 78-83 18755179-3 2008 A robust increase in intracellular Ca(2+) was elicited by a variety of TRPV1 agonists with similar rank order of potency between both cultures: resiniferatoxin>tinyatoxin>capsaicin>N-arachidonoyl-dopamine (NADA). resiniferatoxin 144-159 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 71-76 18635498-7 2008 RTX-induced conduction blockade has an inherent drawback of TRPV1 agonists, the initial excitation (pain); therefore, a local anesthetic should be injected to prevent it. resiniferatoxin 0-3 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 60-65 18405883-7 2008 RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin. resiniferatoxin 42-57 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-18 18405883-7 2008 RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin. resiniferatoxin 42-57 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 123-128 18405883-7 2008 RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin. resiniferatoxin 42-57 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 123-128 18579164-3 2008 Resiniferatoxin (RTX) is an ultra-potent transient receptor potential vanilloid type 1 channel (TRPV1) agonist and can selectively remove TRPV1-expressing primary afferent neurons. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-101 18579164-3 2008 Resiniferatoxin (RTX) is an ultra-potent transient receptor potential vanilloid type 1 channel (TRPV1) agonist and can selectively remove TRPV1-expressing primary afferent neurons. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 138-143 18579164-3 2008 Resiniferatoxin (RTX) is an ultra-potent transient receptor potential vanilloid type 1 channel (TRPV1) agonist and can selectively remove TRPV1-expressing primary afferent neurons. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-101 18579164-3 2008 Resiniferatoxin (RTX) is an ultra-potent transient receptor potential vanilloid type 1 channel (TRPV1) agonist and can selectively remove TRPV1-expressing primary afferent neurons. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 138-143 18579164-7 2008 In RTX-treated rats, the delta-opioid receptor on TRPV1-immunoreactive dorsal root ganglion neurons and afferent terminals in the spinal cord was diminished. resiniferatoxin 3-6 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 50-55 18635503-1 2008 BACKGROUND: Resiniferatoxin (RTX) is a potent agonist of the transient receptor potential vanilloid 1 channel (TRPV1) found in peripheral nociceptors. resiniferatoxin 12-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 111-116 18635503-1 2008 BACKGROUND: Resiniferatoxin (RTX) is a potent agonist of the transient receptor potential vanilloid 1 channel (TRPV1) found in peripheral nociceptors. resiniferatoxin 29-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 111-116 18635503-9 2008 Cell responses to VTD partially recovered, to 42% of control, after incubation in RTX-free medium for 24 h. CONCLUSION: RTX at 10 microM directly and acutely inhibited voltage-dependent Ca(2+) channels, in a TRPV1-independent manner. resiniferatoxin 120-123 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 208-213 18029293-2 2008 VR1 can be selectively ablated by resiniferatoxin (RTX), an ultra-potent excitotoxic agonist, when injected into sensory ganglia. resiniferatoxin 34-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-3 18460982-0 2008 Preventive effect of TRPV1 agonists capsaicin and resiniferatoxin on ischemia/reperfusion-induced renal injury in rats. resiniferatoxin 50-65 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 21-26 18460982-7 2008 In addition, resiniferatoxin (20 microg/kg, subcutaneous), a more selective and potent TRPV1 agonist, showed a renoprotective effect on ischemia/reperfusion-induced renal injury, in a qualitatively similar way to cases seen with capsaicin. resiniferatoxin 13-28 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 87-92 18321652-10 2008 Resinferatoxin (RTX), an ultrapotent transient receptor potential vanilloid type 1 (TRPV1) agonist, was used to inactivate TRPV1 containing nerve fibers/cell bodies. resiniferatoxin 0-14 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 37-82 18321652-10 2008 Resinferatoxin (RTX), an ultrapotent transient receptor potential vanilloid type 1 (TRPV1) agonist, was used to inactivate TRPV1 containing nerve fibers/cell bodies. resiniferatoxin 0-14 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 84-89 18321652-10 2008 Resinferatoxin (RTX), an ultrapotent transient receptor potential vanilloid type 1 (TRPV1) agonist, was used to inactivate TRPV1 containing nerve fibers/cell bodies. resiniferatoxin 0-14 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 123-128 18321652-10 2008 Resinferatoxin (RTX), an ultrapotent transient receptor potential vanilloid type 1 (TRPV1) agonist, was used to inactivate TRPV1 containing nerve fibers/cell bodies. resiniferatoxin 16-19 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 37-82 18321652-10 2008 Resinferatoxin (RTX), an ultrapotent transient receptor potential vanilloid type 1 (TRPV1) agonist, was used to inactivate TRPV1 containing nerve fibers/cell bodies. resiniferatoxin 16-19 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 84-89 18321652-10 2008 Resinferatoxin (RTX), an ultrapotent transient receptor potential vanilloid type 1 (TRPV1) agonist, was used to inactivate TRPV1 containing nerve fibers/cell bodies. resiniferatoxin 16-19 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 123-128 18261748-11 2008 4-MOLDA and OEA failed to alter the heat threshold but inhibited the threshold drop induced by the TRPV1 receptor agonist resiniferatoxin. resiniferatoxin 122-137 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 99-104 18029293-2 2008 VR1 can be selectively ablated by resiniferatoxin (RTX), an ultra-potent excitotoxic agonist, when injected into sensory ganglia. resiniferatoxin 51-54 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-3 17482651-4 2007 TRPV1-expressing sensory neurons were removed by resiniferatoxin (RTX). resiniferatoxin 49-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 18032552-6 2008 Intrapelvic administration of capsaicin or a specific TRPV1 agonist, resiniferatoxin, resulted in a dose-dependent increase in multi-unit ARNA and SP release, and these effects were blocked by the TRVP1 blocker capsazepine. resiniferatoxin 69-84 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 54-59 17517374-5 2007 TRPV1 and TRPA1 RNA were significantly decreased in DRG from RTX-treated rats, indicating functional colocalization of TRPA1 and TRPV1 in sensory nociceptors. resiniferatoxin 61-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 17517374-5 2007 TRPV1 and TRPA1 RNA were significantly decreased in DRG from RTX-treated rats, indicating functional colocalization of TRPA1 and TRPV1 in sensory nociceptors. resiniferatoxin 61-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 129-134 17482651-4 2007 TRPV1-expressing sensory neurons were removed by resiniferatoxin (RTX). resiniferatoxin 66-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 17482651-6 2007 In RTX-treated rats, the alpha(2A)-AR-immunoreactivity co-expressed with TRPV1-expressing terminals in the spinal cord was eliminated. resiniferatoxin 3-6 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 73-78 17169618-3 2007 We examined how sensitization and subsequent desensitization of the TRPV1 by resiniferatoxin (RTX), affected the responses of SARs to inhaled ammonia. resiniferatoxin 77-92 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-73 17169618-3 2007 We examined how sensitization and subsequent desensitization of the TRPV1 by resiniferatoxin (RTX), affected the responses of SARs to inhaled ammonia. resiniferatoxin 94-97 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-73 16769810-5 2006 Resiniferatoxin (RTX) is a specific TRPV1 agonist that, in high doses, selectively destroys C and Adelta fibers. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 36-41 17239544-2 2007 In this study, we determined if removal of TRPV1-expressing afferent neurons by resiniferatoxin (RTX), an ultrapotent capsaicin analog, influences the development of opioid analgesic tolerance. resiniferatoxin 80-95 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 43-48 17239544-2 2007 In this study, we determined if removal of TRPV1-expressing afferent neurons by resiniferatoxin (RTX), an ultrapotent capsaicin analog, influences the development of opioid analgesic tolerance. resiniferatoxin 97-100 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 43-48 17004230-1 2007 AIMS: Resiniferatoxin (RTX), a vanilloid compound and agonist of the transient receptor potential channel 1 (TRPV1), is known for its beneficial effects on neurogenic detrusor overactivity. resiniferatoxin 6-21 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 109-114 17004230-1 2007 AIMS: Resiniferatoxin (RTX), a vanilloid compound and agonist of the transient receptor potential channel 1 (TRPV1), is known for its beneficial effects on neurogenic detrusor overactivity. resiniferatoxin 23-26 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 109-114 16887920-6 2006 Intrapericardial resiniferatoxin (RTX) (0.2 microg/ml, 0.2 ml, 1 min), which desensitizes TRPV1-containing nerve endings, abolished excitatory responses to both BK (n = 8) and CAP (n = 7), and to AC (n = 5) but not to somatic stimuli. resiniferatoxin 17-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 90-95 16887920-6 2006 Intrapericardial resiniferatoxin (RTX) (0.2 microg/ml, 0.2 ml, 1 min), which desensitizes TRPV1-containing nerve endings, abolished excitatory responses to both BK (n = 8) and CAP (n = 7), and to AC (n = 5) but not to somatic stimuli. resiniferatoxin 34-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 90-95 16982866-3 2006 Furthermore, exposure of these cells to TRPV1 agonists, capsaicin (CAP) and resiniferatoxin (RTX), triggered cell death. resiniferatoxin 76-91 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 40-45 16982866-3 2006 Furthermore, exposure of these cells to TRPV1 agonists, capsaicin (CAP) and resiniferatoxin (RTX), triggered cell death. resiniferatoxin 93-96 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 40-45 16769810-5 2006 Resiniferatoxin (RTX) is a specific TRPV1 agonist that, in high doses, selectively destroys C and Adelta fibers. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 36-41 16298071-6 2005 Heat hyperalgesia assessment after chemical desensitization of TRPV1 by resiniferatoxin demonstrates a possible role for TRPV2 in inflammation at high temperatures (>56 degrees C). resiniferatoxin 72-87 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 63-68 16467418-1 2006 Systemic administration of resiniferatoxin (RTX), an ultrapotent capsaicin analogue, removes transient receptor potential vanilloid type 1 (TRPV1)-expressing afferent neurons and impairs thermal but not mechanical nociception in adult animals. resiniferatoxin 27-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 93-138 16467418-1 2006 Systemic administration of resiniferatoxin (RTX), an ultrapotent capsaicin analogue, removes transient receptor potential vanilloid type 1 (TRPV1)-expressing afferent neurons and impairs thermal but not mechanical nociception in adult animals. resiniferatoxin 27-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 140-145 16467418-1 2006 Systemic administration of resiniferatoxin (RTX), an ultrapotent capsaicin analogue, removes transient receptor potential vanilloid type 1 (TRPV1)-expressing afferent neurons and impairs thermal but not mechanical nociception in adult animals. resiniferatoxin 44-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 93-138 16467418-1 2006 Systemic administration of resiniferatoxin (RTX), an ultrapotent capsaicin analogue, removes transient receptor potential vanilloid type 1 (TRPV1)-expressing afferent neurons and impairs thermal but not mechanical nociception in adult animals. resiniferatoxin 44-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 140-145 16467418-4 2006 RTX treatment deleted TRPV1-immunoreactive dorsal root ganglion neurons and nerve terminals in the spinal dorsal horn. resiniferatoxin 0-3 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-27 15659291-3 2005 Pretreatment with resiniferatoxin [200 microg/kg, subcutaneous (s.c.)] blocked the PMA-induced nociceptive behaviour, suggesting that vanilloid VR1 receptor-expressing primary sensory neurons play a major role in this response. resiniferatoxin 18-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 144-147 16037081-0 2005 Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin. resiniferatoxin 66-81 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-54 16037081-0 2005 Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin. resiniferatoxin 66-81 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 56-61 16037081-2 2005 Resiniferatoxin (RTX), an ultrapotent agonist of TRPV1, is under investigation for treatment of urinary bladder hyper-reflexia and chronic pain conditions. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 49-54 16037081-2 2005 Resiniferatoxin (RTX), an ultrapotent agonist of TRPV1, is under investigation for treatment of urinary bladder hyper-reflexia and chronic pain conditions. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 49-54 16037081-3 2005 Here, we have determined the characteristics of RTX-induced responses in cells expressing native and cloned rat TRPV1. resiniferatoxin 48-51 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 112-117 15356216-2 2005 Vanillamides are unmatched in terms of structural simplicity, straightforward synthesis, and safety compared with the more powerful TRPV1 agonists, like the structurally complex phorboid compound resiniferatoxin. resiniferatoxin 196-211 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 132-137 15220301-12 2004 In rats (n = 12) pretreated with resiniferatoxin to destroy muscle afferents containing VR1, capsaicin and H+ responses were blunted. resiniferatoxin 33-48 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 88-91 15601931-8 2004 The anandamide-evoked effect was blocked by capsazepine or by instillation of resiniferatoxin, the ultrapotent TRPV1 agonist, into the bladders 24 hr before the anandamide challenge. resiniferatoxin 78-93 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 111-116 15492017-8 2004 Pretreatment with the ultrapotent TRPV-1 agonist resiniferatoxin (RTX; 2, 20, or 200 microg kg(-1), i.p.) resiniferatoxin 49-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 34-40 15492017-8 2004 Pretreatment with the ultrapotent TRPV-1 agonist resiniferatoxin (RTX; 2, 20, or 200 microg kg(-1), i.p.) resiniferatoxin 66-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 34-40 12243775-4 2002 Olvanil and resiniferatoxin were also effective agonists (EC(50) values of 0.0087 +/- 0.0035 micro M and 0.067 +/- 0.014 micro M, respectively), but 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) and anandamide showed little agonist activity up to 10 micro M. As with human and rat VR1, guinea pig VR1 was also activated by pH below 6.0 and by noxious heat (>42 degrees C). resiniferatoxin 12-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 288-291 12684478-8 2003 Immunofluorescence labeling showed a diminished vanilloid receptor 1 immunoreactivity in dorsal root ganglia neurons and the spinal dorsal horn of RTX-treated rats. resiniferatoxin 147-150 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 48-68 15146439-6 2004 To impair the function of capsaicin-sensitive afferents, the capsaicin receptor (VR1/TRPV1) agonist resiniferatoxin (RTX) was injected subcutaneously (30, 70, and 100 microg/kg on 3 subsequent days) 7 days before CFA administration. resiniferatoxin 100-115 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 61-79 15146439-6 2004 To impair the function of capsaicin-sensitive afferents, the capsaicin receptor (VR1/TRPV1) agonist resiniferatoxin (RTX) was injected subcutaneously (30, 70, and 100 microg/kg on 3 subsequent days) 7 days before CFA administration. resiniferatoxin 100-115 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 81-84 15146439-6 2004 To impair the function of capsaicin-sensitive afferents, the capsaicin receptor (VR1/TRPV1) agonist resiniferatoxin (RTX) was injected subcutaneously (30, 70, and 100 microg/kg on 3 subsequent days) 7 days before CFA administration. resiniferatoxin 100-115 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 85-90 15125461-7 2004 It is reported that resiniferatoxin, [6]-gingerol and lafutidine are compounds that activate VR1 and/or capsaicin-sensitive afferent neurons. resiniferatoxin 20-35 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 93-96 14992587-2 2004 Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 43-48 14992587-2 2004 Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 162-168 14992587-2 2004 Resiniferatoxin (RTX), a potent agonist of TRPV1, and iodoresiniferatoxin (I-RTX), a potent antagonist of TRPV1, both bind with higher affinity to the rat TRPV1 (rTRPV1) than the human (hTRPV1) isoform. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 43-48 14742669-2 2004 IBTU competitively inhibited 45Ca2+ uptake into CHO cells heterologously expressing rat TRPV1, whether induced by capsaicin or resiniferatoxin (Ki = 99 +/- 23 and 93 +/- 34 nM, respectively). resiniferatoxin 127-142 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 88-93 14742669-4 2004 In contrast to its antagonism of vanilloid-induced calcium uptake, IBTU (30 microM) inhibited [3H]resiniferatoxin binding to TRPV1 by less than 10%. resiniferatoxin 98-113 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 125-130 14742669-5 2004 We hypothesize that these dramatically distinct potencies reflect different fractions of TRPV1 in this system: namely, a minor plasma membrane fraction controlling 45Ca2+ uptake, and the predominant intracellular fraction that dominates the [3H]resiniferatoxin binding measurements. resiniferatoxin 245-260 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 89-94 12746222-7 2003 Unilateral intraplantar injection of the VR1 receptor agonist resiniferatoxin (RTX, 0.048 nmol) induced a profound drop of heat threshold to the innocuous range with a maximal effect (8-10 degrees C drop) 5 min after RTX administration. resiniferatoxin 62-77 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-44 12746222-7 2003 Unilateral intraplantar injection of the VR1 receptor agonist resiniferatoxin (RTX, 0.048 nmol) induced a profound drop of heat threshold to the innocuous range with a maximal effect (8-10 degrees C drop) 5 min after RTX administration. resiniferatoxin 79-82 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-44 12746222-7 2003 Unilateral intraplantar injection of the VR1 receptor agonist resiniferatoxin (RTX, 0.048 nmol) induced a profound drop of heat threshold to the innocuous range with a maximal effect (8-10 degrees C drop) 5 min after RTX administration. resiniferatoxin 217-220 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-44 12473388-5 2003 In VR1-HEK293 cells and dorsal root ganglion neurones, Ca(2+) responses were induced by resiniferatoxin>capsaicin=olvanil>PPAHV; all four were full agonists. resiniferatoxin 88-103 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 3-6 12473388-8 2003 Olvanil had a Hill coefficient of approximately 1 whilst capsaicin, resiniferatoxin and PPAHV had Hill coefficients of approximately 2 in VR1-HEK293 cells. resiniferatoxin 68-83 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 138-141 12473388-10 2003 These data show that resiniferatoxin, capsaicin, olvanil and PPAHV, but not scutigeral and isovelleral, are agonists at recombinant rat VR1 receptors and endogenous vanilloid receptors on dorsal root ganglion neurones and in the rat mesenteric arterial bed. resiniferatoxin 21-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 136-139 14599363-9 2002 For both rVR1 and hVR1, time-response waveforms elicited by resiniferatoxin increased more gradually compared to other agonists. resiniferatoxin 60-75 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 9-13 11906962-9 2002 We determined CGRP and NO release from rat stomach and specific [(3)H]-resiniferatoxin (RTX) binding to gastric vanilloid receptor subtype 1 (VR1), which binds capsaicin, using EIA, a microdialysis system and a radioreceptor assay, respectively. resiniferatoxin 71-86 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 112-140 11906962-9 2002 We determined CGRP and NO release from rat stomach and specific [(3)H]-resiniferatoxin (RTX) binding to gastric vanilloid receptor subtype 1 (VR1), which binds capsaicin, using EIA, a microdialysis system and a radioreceptor assay, respectively. resiniferatoxin 88-91 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 112-140 11906962-9 2002 We determined CGRP and NO release from rat stomach and specific [(3)H]-resiniferatoxin (RTX) binding to gastric vanilloid receptor subtype 1 (VR1), which binds capsaicin, using EIA, a microdialysis system and a radioreceptor assay, respectively. resiniferatoxin 88-91 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 142-145 11906962-9 2002 We determined CGRP and NO release from rat stomach and specific [(3)H]-resiniferatoxin (RTX) binding to gastric vanilloid receptor subtype 1 (VR1), which binds capsaicin, using EIA, a microdialysis system and a radioreceptor assay, respectively. resiniferatoxin 71-86 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 142-145 11595435-6 2001 (2) VR-1 agonists (capsaicin, resiniferatoxin, piperine) protect against gastric ulcer of the rat parallel with their sensory stimulating potencies. resiniferatoxin 30-45 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-8 11425572-3 2001 We report here the rationale for the design, the synthesis, and the in vitro characterization of activity in assays for [(3)H]resiniferatoxin binding and (45)Ca influx using heterologously expressed rat VR1. resiniferatoxin 126-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 203-206 11927161-10 2002 Intravesical resiniferatoxin decreased VR1 immunoreactivity transiently. resiniferatoxin 13-28 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 39-42 8246148-0 1993 Competitive inhibition by capsazepine of [3H]resiniferatoxin binding to central (spinal cord and dorsal root ganglia) and peripheral (urinary bladder and airways) vanilloid (capsaicin) receptors in the rat. resiniferatoxin 45-60 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 163-173 11125018-5 2001 Capsaicin and RTX induced large nondesensitizing currents in Xenopus laevis oocytes expressing VR1 (EC50 values were 1300 nM and 0.2 nM, respectively), whereas I-RTX induced no current per se at concentrations up to 10 microM. resiniferatoxin 14-17 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 95-98 11718993-10 2001 Systemic resiniferatoxin administration, however, decreases VR1 expression in dorsal root ganglia by 65-80%, an effect that persists for at least 2 months. resiniferatoxin 9-24 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 60-63 7621890-0 1995 Proton inhibition of [3H]resiniferatoxin binding to vanilloid (capsaicin) receptors in rat spinal cord. resiniferatoxin 25-40 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 52-62 7621890-2 1995 We have used the [3H]resiniferatoxin binding assay utilizing rat spinal cord membranes to elucidate the possible interaction of protons at the vanilloid (capsaicin) receptor. resiniferatoxin 21-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 143-173 11050376-1 2000 Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. resiniferatoxin 11-26 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 103-123 11050376-1 2000 Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. resiniferatoxin 11-26 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 125-129 10510454-0 1999 Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 162-165 8355200-1 1993 Specific [3H]resiniferatoxin (RTX) binding is thought to represent the postulated vanilloid (capsaicin) receptor. resiniferatoxin 13-28 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 71-112 8355200-1 1993 Specific [3H]resiniferatoxin (RTX) binding is thought to represent the postulated vanilloid (capsaicin) receptor. resiniferatoxin 30-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 71-112 1811172-1 1991 We have recently reported the specific binding of [3H]resiniferatoxin to sensory ganglion membranes; this binding appears to represent the postulated vanilloid (capsaicin) receptor. resiniferatoxin 50-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 139-180 34741999-3 2022 Resiniferatoxin was injected into left trigeminal ganglia to ablate TRPV1-expressing neurons. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-73 1723514-5 1990 The action of resiniferatoxin was blocked by Ruthenium Red, a proposed antagonist at the cation channel coupled to the capsaicin receptor. resiniferatoxin 14-29 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 119-137 35482725-1 2022 Resiniferatoxin (RTX), an extract from the spurge plant Euphorbia resinifera, is a potent agonist of the transient receptor potential cation channel subfamily V member 1 (TRPV1), mainly expressed on peripheral nociceptors-a prerequisite for nociceptive heat perception. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 171-176 34416255-4 2021 We used resiniferatoxin (RTX), a TRPV1 agonist, to differentiate the two. resiniferatoxin 8-23 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 33-38 34416255-4 2021 We used resiniferatoxin (RTX), a TRPV1 agonist, to differentiate the two. resiniferatoxin 25-28 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 33-38 35482725-1 2022 Resiniferatoxin (RTX), an extract from the spurge plant Euphorbia resinifera, is a potent agonist of the transient receptor potential cation channel subfamily V member 1 (TRPV1), mainly expressed on peripheral nociceptors-a prerequisite for nociceptive heat perception. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 171-176 30006640-0 2018 Selective ablation of TRPV1 by intrathecal injection of resiniferatoxin in rats increases renal sympathoexcitatory responses and salt sensitivity. resiniferatoxin 56-71 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-27 34015320-10 2021 To date, only resiniferatoxin, a TRPV1 agonist, has been evaluated in clinical trials for cancer pain and showed preliminary positive results. resiniferatoxin 14-29 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 33-38 33936362-3 2021 Resiniferatoxin (RTX) is a transient receptor potential vanilloid 1 (TRPV1), involved in the cardiac sympathetic afferent reflex. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 27-67 33936362-3 2021 Resiniferatoxin (RTX) is a transient receptor potential vanilloid 1 (TRPV1), involved in the cardiac sympathetic afferent reflex. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 69-74 33936362-3 2021 Resiniferatoxin (RTX) is a transient receptor potential vanilloid 1 (TRPV1), involved in the cardiac sympathetic afferent reflex. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 27-67 33936362-3 2021 Resiniferatoxin (RTX) is a transient receptor potential vanilloid 1 (TRPV1), involved in the cardiac sympathetic afferent reflex. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 69-74 32946867-2 2020 We employed resiniferatoxin (ultrapotent TRPV1 agonist) induced chemo-denervation model in rats and studied the effects of TRPV1 ablation on colonic mucus secretion patterns. resiniferatoxin 12-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-46 32064609-7 2020 Perineural application of RTX caused downregulation of TRPV1, CGRP, and IB4 binding and upregulation of VIP in the corresponding DRG and the dorsal horn of the spinal cord. resiniferatoxin 26-29 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 55-60 31811858-1 2020 Excessive sympathetic activity is associated with heart failure and ventricular arrhythmias, which regulated by enhanced cardiac sympathetic afferent reflex, which can be blunted by resiniferatoxin, a selective receptor agonist of transient vanilloid potential 1 (TRPV1) + primary sensory afferents. resiniferatoxin 182-197 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 264-269 31811858-5 2020 Intrathecal resiniferatoxin significantly and selectively abolished the afferent markers expression (TRPV1 and calcitonin gene-related peptide) in dorsal horn and reduced overactivated CSNA. resiniferatoxin 12-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 101-106 31180583-1 2019 OBJECTIVES: To investigate if intravesical administration during spinal shock of resiniferatoxin (RTX), an ultrapotent desensitizing agonist of transient receptor potential vanilloid-1 (TRPV1), would silence TRPV1-expressing bladder afferents at an early stage of disease progression and modulate neurogenic detrusor overactivity (NDO) emergence. resiniferatoxin 81-96 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 144-184 31180583-1 2019 OBJECTIVES: To investigate if intravesical administration during spinal shock of resiniferatoxin (RTX), an ultrapotent desensitizing agonist of transient receptor potential vanilloid-1 (TRPV1), would silence TRPV1-expressing bladder afferents at an early stage of disease progression and modulate neurogenic detrusor overactivity (NDO) emergence. resiniferatoxin 81-96 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 186-191 31180583-1 2019 OBJECTIVES: To investigate if intravesical administration during spinal shock of resiniferatoxin (RTX), an ultrapotent desensitizing agonist of transient receptor potential vanilloid-1 (TRPV1), would silence TRPV1-expressing bladder afferents at an early stage of disease progression and modulate neurogenic detrusor overactivity (NDO) emergence. resiniferatoxin 81-96 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 208-213 31180583-1 2019 OBJECTIVES: To investigate if intravesical administration during spinal shock of resiniferatoxin (RTX), an ultrapotent desensitizing agonist of transient receptor potential vanilloid-1 (TRPV1), would silence TRPV1-expressing bladder afferents at an early stage of disease progression and modulate neurogenic detrusor overactivity (NDO) emergence. resiniferatoxin 98-101 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 144-184 31180583-1 2019 OBJECTIVES: To investigate if intravesical administration during spinal shock of resiniferatoxin (RTX), an ultrapotent desensitizing agonist of transient receptor potential vanilloid-1 (TRPV1), would silence TRPV1-expressing bladder afferents at an early stage of disease progression and modulate neurogenic detrusor overactivity (NDO) emergence. resiniferatoxin 98-101 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 186-191 30576973-1 2019 Resiniferatoxin (RTX) is a daphnane diterpene isolated from the latex of Euphorbia resinifera O. Berg, a potent activator of transient receptor potential vanilloid 1 (TrpV1), with a potency 103-105 times greater than pure capsaicin. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 125-165 30576973-1 2019 Resiniferatoxin (RTX) is a daphnane diterpene isolated from the latex of Euphorbia resinifera O. Berg, a potent activator of transient receptor potential vanilloid 1 (TrpV1), with a potency 103-105 times greater than pure capsaicin. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 167-172 30576973-1 2019 Resiniferatoxin (RTX) is a daphnane diterpene isolated from the latex of Euphorbia resinifera O. Berg, a potent activator of transient receptor potential vanilloid 1 (TrpV1), with a potency 103-105 times greater than pure capsaicin. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 125-165 30576973-1 2019 Resiniferatoxin (RTX) is a daphnane diterpene isolated from the latex of Euphorbia resinifera O. Berg, a potent activator of transient receptor potential vanilloid 1 (TrpV1), with a potency 103-105 times greater than pure capsaicin. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 167-172 30399572-1 2019 Resiniferatoxin (RTX), a selective transient receptor potential vanilloid 1 (TRPV1) receptor agonist, can eliminate TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 35-75 30399572-1 2019 Resiniferatoxin (RTX), a selective transient receptor potential vanilloid 1 (TRPV1) receptor agonist, can eliminate TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 77-82 30399572-1 2019 Resiniferatoxin (RTX), a selective transient receptor potential vanilloid 1 (TRPV1) receptor agonist, can eliminate TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period. resiniferatoxin 0-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 116-121 30399572-1 2019 Resiniferatoxin (RTX), a selective transient receptor potential vanilloid 1 (TRPV1) receptor agonist, can eliminate TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 35-75 30399572-1 2019 Resiniferatoxin (RTX), a selective transient receptor potential vanilloid 1 (TRPV1) receptor agonist, can eliminate TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 77-82 30399572-1 2019 Resiniferatoxin (RTX), a selective transient receptor potential vanilloid 1 (TRPV1) receptor agonist, can eliminate TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period. resiniferatoxin 17-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 116-121 30399572-5 2019 Intrathecal RTX administration abolished TRPV1 expression in the dorsal horn and reduced over-activated CSNA in the TAC rat model. resiniferatoxin 12-15 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-46 30006640-1 2018 This study tested the hypothesis that selective ablation of transient receptor potential vanilloid type 1 (TRPV1)-positive nerve fibers by intrathecal injection of resiniferatoxin (RTX) enhances renal sympathoexcitatory responses and salt sensitivity. resiniferatoxin 164-179 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 60-105 30006640-1 2018 This study tested the hypothesis that selective ablation of transient receptor potential vanilloid type 1 (TRPV1)-positive nerve fibers by intrathecal injection of resiniferatoxin (RTX) enhances renal sympathoexcitatory responses and salt sensitivity. resiniferatoxin 164-179 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 107-112 30006640-1 2018 This study tested the hypothesis that selective ablation of transient receptor potential vanilloid type 1 (TRPV1)-positive nerve fibers by intrathecal injection of resiniferatoxin (RTX) enhances renal sympathoexcitatory responses and salt sensitivity. resiniferatoxin 181-184 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 60-105 30006640-1 2018 This study tested the hypothesis that selective ablation of transient receptor potential vanilloid type 1 (TRPV1)-positive nerve fibers by intrathecal injection of resiniferatoxin (RTX) enhances renal sympathoexcitatory responses and salt sensitivity. resiniferatoxin 181-184 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 107-112 29590555-5 2018 Pretreatment of NTS with the TRPV1 antagonist capsazepine prevented these resiniferatoxin-mediated effects. resiniferatoxin 74-89 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 29-34 29906340-9 2018 In order to further confirm the origin of this reflex, epidural application of a selective afferent neurotoxin (resiniferatoxin, RTX) was used to chronically ablate thoracic TRPV1-expressing afferent soma at the level of T1-T4 dorsal root ganglia pleura. resiniferatoxin 112-127 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 174-179 29906340-9 2018 In order to further confirm the origin of this reflex, epidural application of a selective afferent neurotoxin (resiniferatoxin, RTX) was used to chronically ablate thoracic TRPV1-expressing afferent soma at the level of T1-T4 dorsal root ganglia pleura. resiniferatoxin 129-132 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 174-179