PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19215228-0 2009 Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice. Azoxymethane 97-109 neuraminidase 3 Mus musculus 0-42 19215228-3 2009 Mice were injected with azoxymethane (i.p., 15 mg/kg/week) for 6 weeks, and 4 weeks later ACF had formed in the NEU3 transgenic mice significantly more than in the control wild-type mice. Azoxymethane 24-36 neuraminidase 3 Mus musculus 112-116 19215228-7 2009 The results of this study provide the first evidence that NEU3 essentially increases azoxymethane-induced ACF formation in colon mucosa by suppression of apoptosis, possibly via activation of the EGF signaling pathway, and thus indicate that up-regulation of NEU3 is important to the promotion stage of colorectal carcinogenesis in vivo. Azoxymethane 85-97 neuraminidase 3 Mus musculus 58-62 19215228-7 2009 The results of this study provide the first evidence that NEU3 essentially increases azoxymethane-induced ACF formation in colon mucosa by suppression of apoptosis, possibly via activation of the EGF signaling pathway, and thus indicate that up-regulation of NEU3 is important to the promotion stage of colorectal carcinogenesis in vivo. Azoxymethane 85-97 neuraminidase 3 Mus musculus 259-263