PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27685841-0	2016	Zebularine enhances apoptosis of human osteosarcoma cells by suppressing methylation of ARHI.	pyrimidin-2-one beta-ribofuranoside	0-10	DIRAS family GTPase 3	Homo sapiens	88-92	
27685841-3	2016	Our study aims to investigate the effect and mechanism of action of zebularine on the epigenetic modification of the ARHI gene, and whether this effect may modulate the viability and apoptosis of human osteosarcoma cells.	pyrimidin-2-one beta-ribofuranoside	68-78	DIRAS family GTPase 3	Homo sapiens	117-121	
27685841-5	2016	Zebularine potentiated the expression of ARHI at both the protein and mRNA level.	pyrimidin-2-one beta-ribofuranoside	0-10	DIRAS family GTPase 3	Homo sapiens	41-45	
27685841-6	2016	This was related to the downregulation of methylation of ARHI caused by zebularine.	pyrimidin-2-one beta-ribofuranoside	72-82	DIRAS family GTPase 3	Homo sapiens	57-61	
27685841-10	2016	Moreover, knockdown of ARHI rescued cell viability and apoptosis under the zebularine-treated condition.	pyrimidin-2-one beta-ribofuranoside	75-85	DIRAS family GTPase 3	Homo sapiens	23-27	
27685841-11	2016	We showed that zebularine inhibited viability and promoted apoptosis by disturbing the interaction between DNMT1 and G9a, thereby resulting in lower ARHI methylation and elevated ARHI expression in osteosarcoma cells.	pyrimidin-2-one beta-ribofuranoside	15-25	DIRAS family GTPase 3	Homo sapiens	149-153	
27685841-11	2016	We showed that zebularine inhibited viability and promoted apoptosis by disturbing the interaction between DNMT1 and G9a, thereby resulting in lower ARHI methylation and elevated ARHI expression in osteosarcoma cells.	pyrimidin-2-one beta-ribofuranoside	15-25	DIRAS family GTPase 3	Homo sapiens	179-183