PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24950410-2	2014	AIM: This study aimed to determine the frequency of occurrence of Single Nucleotide Polymorphism (SNP) in position A118G OPRM1 (rs1799971) gene and C.3435 (rs1045642) gene in tramadol users in comparison with normal controls.	Tramadol	175-183	opioid receptor mu 1	Homo sapiens	121-126	
22698264-4	2012	Tramadol"s analgesia derives from relatively weak micro-opioid receptor (MOR) agonism, plus norepinephrine and serotonin reuptake inhibition, provided collectively by the enantiomers of the parent drug and a metabolite that is a stronger MOR agonist, but has lower CNS penetration.	Tramadol	0-8	opioid receptor mu 1	Homo sapiens	50-71	
22698264-4	2012	Tramadol"s analgesia derives from relatively weak micro-opioid receptor (MOR) agonism, plus norepinephrine and serotonin reuptake inhibition, provided collectively by the enantiomers of the parent drug and a metabolite that is a stronger MOR agonist, but has lower CNS penetration.	Tramadol	0-8	opioid receptor mu 1	Homo sapiens	73-76	
22698264-4	2012	Tramadol"s analgesia derives from relatively weak micro-opioid receptor (MOR) agonism, plus norepinephrine and serotonin reuptake inhibition, provided collectively by the enantiomers of the parent drug and a metabolite that is a stronger MOR agonist, but has lower CNS penetration.	Tramadol	0-8	opioid receptor mu 1	Homo sapiens	238-241	
20444752-0	2010	Adverse events in analgesic treatment with tramadol associated with CYP2D6 extensive-metaboliser and OPRM1 high-expression variants.	Tramadol	43-51	opioid receptor mu 1	Homo sapiens	101-106	
16140165-1	2005	Clinical observation found that tramadol, mu opioid receptor (MOR) agonist and serotonin (5-HT) reuptake inhibitor, has a hypoglycemic effect in type 2 diabetes patients.	Tramadol	32-40	opioid receptor mu 1	Homo sapiens	42-60	
16140165-1	2005	Clinical observation found that tramadol, mu opioid receptor (MOR) agonist and serotonin (5-HT) reuptake inhibitor, has a hypoglycemic effect in type 2 diabetes patients.	Tramadol	32-40	opioid receptor mu 1	Homo sapiens	62-65	
16140165-3	2005	This study showed that tramadol activated a neuronal insulin signaling cascade by increasing the induction of insulin receptor substrate-2 expression in primary cultured neuronal cells while this activation was suppressed by naloxone (MOR inhibitor) and dexamethasone (non-specific inhibitor of MOR and 5-HT receptor, DEX).	Tramadol	23-31	opioid receptor mu 1	Homo sapiens	235-238	
16140165-3	2005	This study showed that tramadol activated a neuronal insulin signaling cascade by increasing the induction of insulin receptor substrate-2 expression in primary cultured neuronal cells while this activation was suppressed by naloxone (MOR inhibitor) and dexamethasone (non-specific inhibitor of MOR and 5-HT receptor, DEX).	Tramadol	23-31	opioid receptor mu 1	Homo sapiens	295-298	
16140165-8	2005	The data suggest that tramadol ameliorates peripheral glucose metabolism through central activation of MOR, and that central and peripheral glucose metabolism are therefore likely to be interrelated.	Tramadol	22-30	opioid receptor mu 1	Homo sapiens	103-106	
29190510-2	2018	Downstream metabolic enzymes encoded by UGT2B7, ABCB1, OPRM1, and COMT also have been implicated in variable individual response to drugs due to their activity at different stages of the tramadol ADME (absorption, distribution, metabolism, and excretion) process.	Tramadol	187-195	opioid receptor mu 1	Homo sapiens	55-60	
24624916-1	2014	AIM: This study was performed to develop an algorithm using polymorphisms of CYP2D6, p-gp, OPRM1, COMT and psychological variables to predict tramadol response in Chinese patients recovering from upper limb fracture internal fixation surgery.	Tramadol	142-150	opioid receptor mu 1	Homo sapiens	91-96