PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27470363-13	2016	On molecular level, the expression of the pro-apoptotic Bax and Caspase-3 showed a significant increase whereas the anti-apoptotic Bcl-2 decreased markedly indicating that tramadol is harmful at cellular level and can induce apoptotic changes in brain tissues.	Tramadol	172-180	BCL2 associated X, apoptosis regulator	Rattus norvegicus	56-59	
32782734-8	2020	In addition, tramadol induced a significant decrease in Bcl-2 gene expression, and increase in Bax gene expression.	Tramadol	13-21	BCL2 associated X, apoptosis regulator	Rattus norvegicus	95-98	
30508735-7	2019	Monoamine neurotransmitters, 8-oxo-7,8-dihydro-2"-deoxyguanosine, and gene and protein expression levels of p53 and Bax were significantly increased in the cerebrum of tramadol-induced rats.	Tramadol	168-176	BCL2 associated X, apoptosis regulator	Rattus norvegicus	116-119