PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15276689-5 2004 The oral and intrathecally administered tramadol, a mu-opioid and naproxen, a nonselective COX inhibitor produced dose-dependent antinociception, however, rofecoxib, a selective COX-2 inhibitor lacked analgesic efficacy in writhing test. Tramadol 40-48 cytochrome c oxidase II, mitochondrial Mus musculus 178-183