PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30632799-0	2019	Tramadol induces changes in Delta-FosB, micro-opioid receptor, and p-CREB level in the nucleus accumbens and prefrontal cortex of male Wistar rat.	Tramadol	0-8	cAMP responsive element binding protein 1	Rattus norvegicus	69-73	
30632799-11	2019	RESULTS: In the NAC, acute tramadol exposure increases the levels of MOR and p-CREB.	Tramadol	27-35	cAMP responsive element binding protein 1	Rattus norvegicus	79-83	
30632799-12	2019	Moreover, chronic tramadol administration in this region results in elevated levels of MOR, DeltaFosB and p-CREB compared with saline-treated rats.	Tramadol	18-26	cAMP responsive element binding protein 1	Rattus norvegicus	108-112	
30632799-13	2019	The levels of MOR and p-CREB in the PFC increased in both acute and chronic tramadol exposure.	Tramadol	76-84	cAMP responsive element binding protein 1	Rattus norvegicus	24-28	
30632799-16	2019	CONCLUSION: We concluded that both CREB and DeltaFosB played a role in tramadol dependence.	Tramadol	71-79	cAMP responsive element binding protein 1	Rattus norvegicus	35-39