PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29027194-2 2018 The aim of this study was to characterize the pediatric predictive performance of the PBPK approach for 10 drugs extensively metabolized by CYP1A2 (theophylline), CYP2C8 (desloratidine, montelukast), CYP2C9 (diclofenac), CYP2C19 (esomeprazole, lansoprazole), CYP2D6 (tramadol), and CYP3A4 (itraconazole, ondansetron, sufentanil). Tramadol 267-275 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 140-146