PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15992354-9 2005 BBR3464 has shown in vivo activity at its MTD in several pre-clinical and clinical trials; however, recent phase II trials have shown that BBR3464, and other multi-nuclear platinum drugs, did not yield results substantially different from cisplatin, possibly due to their binding and degradation by human plasma proteins. BBR 3464 0-7 metallothionein 1E Homo sapiens 42-45