PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29670376-0	2018	Butein activates p53 in hepatocellular carcinoma cells via blocking MDM2-mediated ubiquitination.	butein	0-6	tumor protein p53	Homo sapiens	17-20	
33325610-0	2021	Butein induces cellular senescence through reactive oxygen species-mediated p53 activation in osteosarcoma U-2 OS cells.	butein	0-6	tumor protein p53	Homo sapiens	76-79	
33325610-7	2021	Knockdown of p53 suppressed the senescence and rescued the viability in butein-treated U-2 OS cells.	butein	72-78	tumor protein p53	Homo sapiens	13-16	
33325610-10	2021	Taken together, our data proposed the increased ROS by butein exposure activated p53, and the activated p53 was involved in the anti-proliferative effect of butein via inducing senescence in U-2 OS cells.	butein	55-61	tumor protein p53	Homo sapiens	81-84	
33325610-10	2021	Taken together, our data proposed the increased ROS by butein exposure activated p53, and the activated p53 was involved in the anti-proliferative effect of butein via inducing senescence in U-2 OS cells.	butein	157-163	tumor protein p53	Homo sapiens	104-107	
29670376-1	2018	Introduction: In this study, we aimed to investigate the effect of butein on p53 in hepatocellular carcinoma (HCC) cells and the related molecular mechanisms by which p53 was activated.	butein	67-73	tumor protein p53	Homo sapiens	77-80	
29670376-1	2018	Introduction: In this study, we aimed to investigate the effect of butein on p53 in hepatocellular carcinoma (HCC) cells and the related molecular mechanisms by which p53 was activated.	butein	67-73	tumor protein p53	Homo sapiens	167-170	
29670376-9	2018	Mechanism studies demonstrated that the interaction between MDM2 and p53 was blocked by butein and MDM2-mediated p53 ubiquitination was substantially decreased.	butein	88-94	tumor protein p53	Homo sapiens	69-72	
29670376-9	2018	Mechanism studies demonstrated that the interaction between MDM2 and p53 was blocked by butein and MDM2-mediated p53 ubiquitination was substantially decreased.	butein	88-94	tumor protein p53	Homo sapiens	113-116	
29670376-10	2018	Short-hairpin RNA experiment results showed that the sensitivity of HCC cells to butein was substantially impaired after p53 was knocked down and butein-induced apoptosis was dramatically decreased.	butein	81-87	tumor protein p53	Homo sapiens	121-124	
29670376-11	2018	In vivo experiments validated substantial antitumor efficacy of butein against HepG2 xenograft growth, and the expression of p53 in butein-treated tumor tissue was significantly increased.	butein	132-138	tumor protein p53	Homo sapiens	125-128	
29670376-12	2018	Conclusion: Butein demonstrated potent antitumor activities in HCC by activating p53, and butein or its analogs had therapeutic potential for HCC management.	butein	12-18	tumor protein p53	Homo sapiens	81-84	
26676515-4	2016	The present study demonstrated that butein-induced apoptosis was mediated by p53.	butein	36-42	tumor protein p53	Homo sapiens	77-80	
26676515-5	2016	KBM5 chronic myeloid leukemia (CML) cells expressing wild-type p53 were more sensitive to butein compared with p53-null K562 CML cells in terms of apoptotic cell death.	butein	90-96	tumor protein p53	Homo sapiens	63-66	
26676515-8	2016	Therefore, the present study suggested that p53 causes the butein-mediated apoptosis of leukemic cells.	butein	59-65	tumor protein p53	Homo sapiens	44-47