PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7905826-4 1994 High levels of P-glycoprotein mRNAs were found in both liver tumor samples and the two hepatoma cell clones as assessed by Northern blotting; both RHC1 and RHC2 cells displayed altered liver functions commonly observed in rat hepatoma cells, particularly the decreased expression of albumin and overexpression of the fetal glutathione S-transferase 7-7. Glutathione 323-334 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 15-29 23734981-7 2013 The permeability of glutathione-conjugated BSA nanoparticles across the monolayer of MDCK-MDR1 endothelial tight junction was shown significantly higher than that of unconjugated nanoparticles and fluorescein sodium solution. Glutathione 20-31 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 90-94 20926128-9 2011 Thus, according to the achieved results it is suggested that PAA-cysteine in combination with GSH would be a potentially valuable tool for improving the oral bioavailability of P-gp and CYP450 substrates such as paclitaxel. Glutathione 94-97 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 177-181 19505374-0 2009 Glutathione depletion upregulates P-glycoprotein expression at the blood-brain barrier in rats. Glutathione 0-11 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 34-48 19505374-3 2009 Using an in-vivo system, we have investigated whether glutathione depletion changed expression of P-glycoprotein at the blood-brain barrier in rats. Glutathione 54-65 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 98-112 19505374-10 2009 At the same time, the Kp values of Rh123 suggested that function of P-glycoprotein was significantly enhanced at the blood-brain barrier in rats with GSH depletion induced by diethyl maleate. Glutathione 150-153 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 68-82 19505374-13 2009 CONCLUSIONS: The oxidative stress induced by GSH depletion played a positive role in the regulation of function and expression of P-glycoprotein at the blood-brain barrier in rats. Glutathione 45-48 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 130-144 17716840-6 2008 Transport studies across Caco-2 monolayers showed that P-gp inhibition is dependent on the average molecular mass of thiolated chitosan showing following rank order: 0.5% (m/v) Chito-150kDa-TBA/GSH>0.5% (m/v) Chito-9.4kDa-TBA/GSH>0.5% (m/v) Chito-600kDa-TBA/GSH. Glutathione 194-197 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 55-59 17716840-6 2008 Transport studies across Caco-2 monolayers showed that P-gp inhibition is dependent on the average molecular mass of thiolated chitosan showing following rank order: 0.5% (m/v) Chito-150kDa-TBA/GSH>0.5% (m/v) Chito-9.4kDa-TBA/GSH>0.5% (m/v) Chito-600kDa-TBA/GSH. Glutathione 229-232 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 55-59 17716840-6 2008 Transport studies across Caco-2 monolayers showed that P-gp inhibition is dependent on the average molecular mass of thiolated chitosan showing following rank order: 0.5% (m/v) Chito-150kDa-TBA/GSH>0.5% (m/v) Chito-9.4kDa-TBA/GSH>0.5% (m/v) Chito-600kDa-TBA/GSH. Glutathione 229-232 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 55-59 17365284-1 2007 It was the aim of this study to investigate the effect of chitosan-4-thiobutylamidine (Ch-TBA) and reduced glutathione (GSH) on the absorption of P-glycoprotein (P-gp) and multidrug resistance protein (MRP) substrate saquinavir in vitro and in vivo. Glutathione 107-118 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 146-160 17365284-1 2007 It was the aim of this study to investigate the effect of chitosan-4-thiobutylamidine (Ch-TBA) and reduced glutathione (GSH) on the absorption of P-glycoprotein (P-gp) and multidrug resistance protein (MRP) substrate saquinavir in vitro and in vivo. Glutathione 107-118 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 162-166 17365284-1 2007 It was the aim of this study to investigate the effect of chitosan-4-thiobutylamidine (Ch-TBA) and reduced glutathione (GSH) on the absorption of P-glycoprotein (P-gp) and multidrug resistance protein (MRP) substrate saquinavir in vitro and in vivo. Glutathione 120-123 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 146-160 17365284-1 2007 It was the aim of this study to investigate the effect of chitosan-4-thiobutylamidine (Ch-TBA) and reduced glutathione (GSH) on the absorption of P-glycoprotein (P-gp) and multidrug resistance protein (MRP) substrate saquinavir in vitro and in vivo. Glutathione 120-123 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 162-166 16923159-0 2006 Up-regulation of P-glycoprotein expression by glutathione depletion-induced oxidative stress in rat brain microvessel endothelial cells. Glutathione 46-57 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 17-31 16923159-3 2006 In this study, we investigated the effect of such stress, produced with the GSH synthesis inhibitor l-buthionine-(S,R)-sulfoximine (BSO), on expression of P-glycoprotein (Pgp) in primary cultured rat brain microvessel endothelial cells that comprise the blood-brain barrier (BBB). Glutathione 76-79 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 155-169 16923159-3 2006 In this study, we investigated the effect of such stress, produced with the GSH synthesis inhibitor l-buthionine-(S,R)-sulfoximine (BSO), on expression of P-glycoprotein (Pgp) in primary cultured rat brain microvessel endothelial cells that comprise the blood-brain barrier (BBB). Glutathione 76-79 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 171-174 16923159-11 2006 Therefore, the transport of Pgp substrates may be affected by changing Pgp expression under conditions of chronic oxidative stress induced by GSH depletion. Glutathione 142-145 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 28-31 16923159-11 2006 Therefore, the transport of Pgp substrates may be affected by changing Pgp expression under conditions of chronic oxidative stress induced by GSH depletion. Glutathione 142-145 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 71-74