PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11216765-2 2001 The aim of this study was to determine if the demethylating agent, 5-Aza-2"-deoxycytidine (DAC) and if the histone deacetylase inhibitor Depsipeptide FR901228 (DP) could enhance MAGE-3 expression in lung and esophageal cancer cells. dp 160-162 MAGE family member A3 Homo sapiens 178-184 11216765-6 2001 RESULTS: Relative to untreated controls, MAGE-3 expression was enhanced 32-fold (range 3.9 to 110) by DAC alone (0.1 micromol/L x 72 h), 2.1-fold (0.4 to 4.2) by DP alone (25 ng/mL x 6h), and 57-fold (4.6 to 209) by sequential DAC/DP exposure. dp 162-164 MAGE family member A3 Homo sapiens 41-47 11216765-6 2001 RESULTS: Relative to untreated controls, MAGE-3 expression was enhanced 32-fold (range 3.9 to 110) by DAC alone (0.1 micromol/L x 72 h), 2.1-fold (0.4 to 4.2) by DP alone (25 ng/mL x 6h), and 57-fold (4.6 to 209) by sequential DAC/DP exposure. dp 231-233 MAGE family member A3 Homo sapiens 41-47 11216765-11 2001 CONCLUSIONS: Sequential DAC/DP treatment may be a novel strategy to simultaneously augment MAGE-3 expression and induce growth arrest in thoracic malignancies. dp 28-30 MAGE family member A3 Homo sapiens 91-97