PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19117633-4	2009	To evaluate the role of iNOS expression in T1D, this study used a novel iNOS inhibitor ONO-1714.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	87-95	nitric oxide synthase 2, inducible	Mus musculus	24-28	
19283362-6	2009	We assessed the involvement of iNOS in diabetes-induced malformation by administering ONO-1714, a specific inhibitor of iNOS, to pregnant mice with streptozotocin-induced diabetic mice and by screening mice with iNOS deficiency due to genetic knockout (iNos(-/-)).	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	86-94	nitric oxide synthase 2, inducible	Mus musculus	120-124	
19117633-4	2009	To evaluate the role of iNOS expression in T1D, this study used a novel iNOS inhibitor ONO-1714.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	87-95	nitric oxide synthase 2, inducible	Mus musculus	72-76	
18997441-2	2008	We previously showed that the expression of iNOS and lung injury were suppressed by inhalation of a novel iNOS inhibitor, ONO-1714, in mice with Candida-induced ALI, and that nitric oxide produced by iNOS and apoptosis of epithelial cells were found to have a crucial role in Candida-induced ALI.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	122-130	nitric oxide synthase 2, inducible	Mus musculus	44-48	
18997441-9	2008	Inhibition of iNOS-derived NO production by ONO-1714 inhalation ameliorated Candida-induced ALI and improved survival by suppressing apoptosis of alveolar epithelial cells.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	44-52	nitric oxide synthase 2, inducible	Mus musculus	14-18	
18997441-2	2008	We previously showed that the expression of iNOS and lung injury were suppressed by inhalation of a novel iNOS inhibitor, ONO-1714, in mice with Candida-induced ALI, and that nitric oxide produced by iNOS and apoptosis of epithelial cells were found to have a crucial role in Candida-induced ALI.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	122-130	nitric oxide synthase 2, inducible	Mus musculus	106-110	
18997441-2	2008	We previously showed that the expression of iNOS and lung injury were suppressed by inhalation of a novel iNOS inhibitor, ONO-1714, in mice with Candida-induced ALI, and that nitric oxide produced by iNOS and apoptosis of epithelial cells were found to have a crucial role in Candida-induced ALI.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	122-130	nitric oxide synthase 2, inducible	Mus musculus	106-110	
18997441-7	2008	Our results showed that apoptosis was suppressed by inhibition of iNOS-derived NO production by ONO-1714 inhalation.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	96-104	nitric oxide synthase 2, inducible	Mus musculus	66-70	
17417780-0	2007	A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	54-62	nitric oxide synthase 2, inducible	Mus musculus	11-42	
16982182-0	2007	A novel potent inhibitor of inducible nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury in mice.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	61-69	nitric oxide synthase 2, inducible	Mus musculus	28-59	
17510494-4	2007	Mice were pretreated by inhalation of saline or ONO-1714, a selective iNOS inhibitor, and were given an intravenous injection of Candida albicans to induce ALI.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	48-56	nitric oxide synthase 2, inducible	Mus musculus	70-74	
17510494-7	2007	Inhalation of ONO-1714 markedly suppressed nitrotyrosine production and inhibited the expression of iNOS mRNA as well as proteins in the lung.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	14-22	nitric oxide synthase 2, inducible	Mus musculus	100-104	
12003824-6	2002	The selective iNOS inhibitor (1S,5S,6R,7R)- 7-chloro-3-imino-5-methyl-2-azabicyclo[4.1.0]heptane hydrochloride (ONO-1714) was used to examine the effects of iNOS induction on myocardial contractility.	7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane	112-120	nitric oxide synthase 2, inducible	Mus musculus	14-18