PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33014117-0 2020 Zi Shen Huo Luo Formula Prevents Aldosterone-Induced Cardiomyocyte Hypertrophy and Cardiac Fibroblast Proliferation by Regulating the Striatin-Mediated MR/EGFR/ERK Signaling Pathway. Aldosterone 33-44 epidermal growth factor receptor Rattus norvegicus 155-159 33014117-11 2020 In conclusion, ZSHLF inhibits the downstream EGFR/ERK signaling pathway by blocking the striatin-mediated membrane localization of MR, which may be an important molecular mechanism by which ZSHLF improves aldosterone-induced myocardial remodeling. Aldosterone 205-216 epidermal growth factor receptor Rattus norvegicus 45-49 27317889-0 2016 Epidermal growth factor receptor signaling mediates aldosterone-induced profibrotic responses in kidney. Aldosterone 52-63 epidermal growth factor receptor Rattus norvegicus 0-32 27317889-7 2016 In cultured mesangial cells, inhibition of EGFR also abrogated aldosterone-induced expression of extracellular matrix proteins, cell proliferation and migration. Aldosterone 63-74 epidermal growth factor receptor Rattus norvegicus 43-47 27317889-8 2016 We also demonstrated that aldosterone induced the phosphorylation of EGFR through generation of ROS. Aldosterone 26-37 epidermal growth factor receptor Rattus norvegicus 69-73 27317889-10 2016 Taken together, we concluded that aldosterone-mediated tissue fibrosis relies on ROS induced EGFR/ERK activation, highlighting EGFR as a potential therapeutic target for modulating renal fibrosis. Aldosterone 34-45 epidermal growth factor receptor Rattus norvegicus 93-97 27317889-10 2016 Taken together, we concluded that aldosterone-mediated tissue fibrosis relies on ROS induced EGFR/ERK activation, highlighting EGFR as a potential therapeutic target for modulating renal fibrosis. Aldosterone 34-45 epidermal growth factor receptor Rattus norvegicus 127-131 17311890-4 2007 We investigated the effect of aldosterone on EGFR expression in the aorta of adrenalectomized rats and in human aorta smooth muscle cells (HAoSMC) in primary culture. Aldosterone 30-41 epidermal growth factor receptor Rattus norvegicus 45-49 23484111-1 2013 Previous in vitro studies indicated that aldosterone nongenomically phosphorylates epidermal growth factor receptor (EGFR) through activation of upstream signals, heat shock protein 90 beta (Hsp90 beta ), and cytosolic (c)-Src kinase. Aldosterone 41-52 epidermal growth factor receptor Rattus norvegicus 83-115 23484111-1 2013 Previous in vitro studies indicated that aldosterone nongenomically phosphorylates epidermal growth factor receptor (EGFR) through activation of upstream signals, heat shock protein 90 beta (Hsp90 beta ), and cytosolic (c)-Src kinase. Aldosterone 41-52 epidermal growth factor receptor Rattus norvegicus 117-121 22814207-7 2012 Aldosterone-induced fibroblast proliferation was dependent upon the kinase activity of growth factor receptors [platelet-derived growth factor receptor (PDGFR) and epidermal growth factor receptor]. Aldosterone 0-11 epidermal growth factor receptor Rattus norvegicus 164-196 22174146-6 2011 Similarly, an increase in superoxide anion promoted by an equipotent dose of aldosterone (10 nmol l(-1)) was blocked by spironolactone or eplerenone, by preventing epidermal growth factor receptor transactivation, but not by inhibiting glucocorticoid receptors or protein synthesis, suggesting non-genomic MR effects. Aldosterone 77-88 epidermal growth factor receptor Rattus norvegicus 164-196 22174146-8 2011 We found that aldosterone increased phosphorylation of the redox-sensitive kinases ERK1/2-p90RSK and the NHE-1, effects that were eliminated by eplerenone or by preventing epidermal growth factor receptor transactivation. Aldosterone 14-25 epidermal growth factor receptor Rattus norvegicus 172-204 22016493-11 2011 Aldosterone enhances the NHE-1 activity via transactivation of the EGFR, formation of reactive oxygen species, and phosphorylation of the exchanger. Aldosterone 0-11 epidermal growth factor receptor Rattus norvegicus 67-71 22016493-12 2011 These results call attention to the consideration of the EGFR as a new potential therapeutic target of the cardiovascular pathologies involving the participation of aldosterone. Aldosterone 165-176 epidermal growth factor receptor Rattus norvegicus 57-61 20421514-10 2010 Our data support the hypothesis that increased constitutive MR signaling may promote and amplify age-associated inflammation that accompanies arterial aging through increased angiotensin II-stimulated expression of MR and enhanced sensitivity to aldosterone-mediated extracellular signal-regulated kinase 1/2 activation, likely related to increased epidermal growth factor receptor expression. Aldosterone 246-257 epidermal growth factor receptor Rattus norvegicus 349-381 22016493-0 2011 Aldosterone stimulates the cardiac Na(+)/H(+) exchanger via transactivation of the epidermal growth factor receptor. Aldosterone 0-11 epidermal growth factor receptor Rattus norvegicus 83-115 22016493-3 2011 We tested whether aldosterone-induced NHE-1 stimulation involves the transactivation of the epidermal growth factor receptor (EGFR). Aldosterone 18-29 epidermal growth factor receptor Rattus norvegicus 92-124 22016493-3 2011 We tested whether aldosterone-induced NHE-1 stimulation involves the transactivation of the epidermal growth factor receptor (EGFR). Aldosterone 18-29 epidermal growth factor receptor Rattus norvegicus 126-130 22016493-7 2011 Aldosterone-induced NHE-1 stimulation was abolished by the EGFR kinase inhibitor AG1478, suggesting that is mediated by transactivation of EGFR. Aldosterone 0-11 epidermal growth factor receptor Rattus norvegicus 59-63 22016493-7 2011 Aldosterone-induced NHE-1 stimulation was abolished by the EGFR kinase inhibitor AG1478, suggesting that is mediated by transactivation of EGFR. Aldosterone 0-11 epidermal growth factor receptor Rattus norvegicus 139-143 21196724-1 2011 BACKGROUND: In vitro studies have demonstrated that aldosterone elicits nongenomic actions by enhancing protein expressions of phosphorylated epidermal growth factor receptor (pEGFR) and phosphorylated extracellular signal-regulated kinases 1/2 (pERK1/2). Aldosterone 52-63 epidermal growth factor receptor Rattus norvegicus 142-174 21196724-10 2011 These results indicate that aldosterone induces phosphorylation of EGFR upstream of ERK1/2. Aldosterone 28-39 epidermal growth factor receptor Rattus norvegicus 67-71 12939263-5 2003 Here we show that aldosterone stimulates EGFR expression in renal tissue of adrenalectomized rats and in human renal primary cell cultures. Aldosterone 18-29 epidermal growth factor receptor Rattus norvegicus 41-45 11507012-4 2001 We hypothesized that mRNA for the EGF-stimulated pathway would be elevated in the vasculature of stroke-prone spontaneously hypertensive rats (SHRSP) and that this and experimental ischemic cerebral infract size would be reduced by aldosterone inhibition with spironolactone. Aldosterone 232-243 epidermal growth factor receptor Rattus norvegicus 34-37