PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2492934-0 1989 Growth hormone response to diazepam, clonidine and glucagon in patients with epilepsy. Diazepam 27-35 growth hormone 1 Homo sapiens 0-14 2183879-0 1990 Growth hormone response to intravenous diazepam and placebo in 82 healthy men. Diazepam 39-47 growth hormone 1 Homo sapiens 0-14 2183879-2 1990 Both diazepam doses had a significant effect on the growth hormone secretion, with peak values occurring between 30 and 60 min postinfusion, after which levels returned to baseline. Diazepam 5-13 growth hormone 1 Homo sapiens 52-66 2183879-4 1990 Individual GH responses to diazepam were variable and, when a cut-off point of 7.5 ng/ml GH increase before 90 min postdrug administration was used, 1% of the men demonstrated a response after placebo, 17% after low-dose diazepam, and 37% following high-dose diazepam. Diazepam 27-35 growth hormone 1 Homo sapiens 11-13 2107017-3 1990 Administration of diazepam (10 mg single oral dose) to those cases not responding to bromocriptine induced a decrease in GH in 58% of the cases and an increase in GH in 42%. Diazepam 18-26 growth hormone 1 Homo sapiens 121-123 2107017-3 1990 Administration of diazepam (10 mg single oral dose) to those cases not responding to bromocriptine induced a decrease in GH in 58% of the cases and an increase in GH in 42%. Diazepam 18-26 growth hormone 1 Homo sapiens 163-165 2492934-4 1989 Treatment with phenytoin resulted in a significant increase in growth hormone release after diazepam and glucagon, whilst sodium valproate reduced the growth hormone response to diazepam. Diazepam 178-186 growth hormone 1 Homo sapiens 151-165 2492934-3 1989 There was a reduction in growth hormone response to diazepam in both treated and untreated patients with epilepsy compared to controls. Diazepam 52-60 growth hormone 1 Homo sapiens 25-39 2492934-4 1989 Treatment with phenytoin resulted in a significant increase in growth hormone release after diazepam and glucagon, whilst sodium valproate reduced the growth hormone response to diazepam. Diazepam 92-100 growth hormone 1 Homo sapiens 63-77 3063133-2 1988 Both diazepam and thiopental, commonly used agents for inducing anaesthesia, show some typical neuroendocrine effects such as liberation of human growth hormone (hGH) in addition to their well-known influences on the cardiovascular system. Diazepam 5-13 growth hormone 1 Homo sapiens 146-160 2908516-13 1988 Blunting of the growth hormone response to diazepam was the most sensitive and reliable method of detecting tolerance to the benzodiazepines. Diazepam 43-51 growth hormone 1 Homo sapiens 16-30 3628621-2 1987 An acute dose of diazepam (15 mg) significantly attenuated the prolactin and growth hormone responses to intravenous L-tryptophan. Diazepam 17-25 growth hormone 1 Homo sapiens 77-91 2871819-2 1986 Diazepam administration (4.4 to 140 micrograms/kg, cumulative dose) resulted in a dose-dependent decrease in saccadic eye velocity and plasma cortisol level as well as a dose-dependent increase in self-rated sedation and plasma growth hormone level. Diazepam 0-8 growth hormone 1 Homo sapiens 228-242 3023221-0 1986 Evidence for the involvement of the opiate-receptors in the diazepam-induced human growth hormone secretion. Diazepam 60-68 growth hormone 1 Homo sapiens 83-97 2871819-4 1986 The diazepam-induced changes in saccadic eye velocity, sedation, and growth hormone and cortisol levels were highly correlated with each other and with increasing plasma diazepam concentration. Diazepam 4-12 growth hormone 1 Homo sapiens 69-83 2871819-4 1986 The diazepam-induced changes in saccadic eye velocity, sedation, and growth hormone and cortisol levels were highly correlated with each other and with increasing plasma diazepam concentration. Diazepam 170-178 growth hormone 1 Homo sapiens 69-83 6138010-0 1983 Long-term benzodiazepine administration blunts growth hormone response to diazepam. Diazepam 74-82 growth hormone 1 Homo sapiens 47-61 6706293-1 1984 Diazepam has been reported to influence pituitary hormone secretion, with several studies claiming that diazepam provokes growth hormone release. Diazepam 0-8 growth hormone 1 Homo sapiens 122-136 6706293-1 1984 Diazepam has been reported to influence pituitary hormone secretion, with several studies claiming that diazepam provokes growth hormone release. Diazepam 104-112 growth hormone 1 Homo sapiens 122-136 6706293-8 1984 We conclude that diazepam inconsistently stimulates growth hormone secretion and should not be relied upon as a test of growth hormone reserve. Diazepam 17-25 growth hormone 1 Homo sapiens 52-66 6138010-5 1983 The results clearly demonstrate tolerance to the growth hormone-releasing effect of diazepam, but do not suggest receptor supersensitivity after withdrawal of benzodiazepine therapy. Diazepam 84-92 growth hormone 1 Homo sapiens 49-63 6841564-0 1983 Effect of the benzodiazepine derivative, diazepam, on the clonidine-stimulated human growth hormone secretion. Diazepam 41-49 growth hormone 1 Homo sapiens 85-99 7108150-0 1982 The response of growth hormone and prolactin to oral diazepam in diabetics. Diazepam 53-61 growth hormone 1 Homo sapiens 16-30 370137-0 1979 The effect of methysergide, pimozide, and sodium valproate on the diazepam-stimulated growth hormone secretion in man. Diazepam 66-74 growth hormone 1 Homo sapiens 86-100 7178369-0 1982 Inhibitory effect of phentolamine on diazepam-induced growth hormone secretion and lack of effect of diazepam on prolactin secretion in man. Diazepam 37-45 growth hormone 1 Homo sapiens 54-68 7178369-1 1982 Phentolamine, a postsynaptic noradrenergic (NA) receptor blocker, inhibits diazepam-induced growth hormone (GH) secretion in man. Diazepam 75-83 growth hormone 1 Homo sapiens 92-106 7178370-0 1982 Comparison of growth hormone stimulation induced by desimipramine, diazepam and metaclazepam in man. Diazepam 67-75 growth hormone 1 Homo sapiens 14-28 7024080-0 1981 Diazepam test of growth hormone secretion. Diazepam 0-8 growth hormone 1 Homo sapiens 17-31 7203397-2 1980 A peak growth hormone response of 13.5 +/- 0.3 ng/ml (mean +/- SEM) significantly above the base line (p less than 0.001) was achieved when diazepam was given alone. Diazepam 140-148 growth hormone 1 Homo sapiens 7-21 20575772-0 1999 Effect of diazepam on growth hormone secretion in abstinent alcoholic men. Diazepam 10-18 growth hormone 1 Homo sapiens 22-36 916171-0 1977 [The effect of diazepam-ketamine-nitrous oxide anesthesia and surgery on plasma levels of thyroid hormones, growth hormone, and insulin in man (author"s transl)]. Diazepam 15-23 growth hormone 1 Homo sapiens 108-122 1100541-3 1975 There was a dose-dependent rise in GH after diazepam administration, and the rise was related to the peak plasma level of the drug. Diazepam 44-52 growth hormone 1 Homo sapiens 35-37 1100541-4 1975 A highly significant correlation between the concentrations of serum GH and plasma diazepam was found. Diazepam 83-91 growth hormone 1 Homo sapiens 69-71 1100541-6 1975 and oral administration of 10 mg of diazepam, the peak GH levels, reached in 30 and 60 minutes (19.6+/-2.9 and 15.2+/-3.2ng/ml, respectively), were significantly higher than those during saline and placebo periods (4.3+/-0.8 and 5.9+/-1.1 ng/ml, respectively). Diazepam 36-44 growth hormone 1 Homo sapiens 55-57 7779243-4 1995 Compared with untreated patients, alprazolam-treated patients displayed significantly less diazepam-induced change in peak saccadic velocity, saccade latency, growth hormone secretion, memory, and self-rated levels of sedation. Diazepam 91-99 growth hormone 1 Homo sapiens 159-173