PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12959254-3 1990 Administration of diazepam or oxazepam caused a different response of the rat hepatic microsomal cytochrome P-450 dependent monooxygenase system. Diazepam 18-26 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 97-113 8148870-0 1993 Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner. Diazepam 39-47 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-15 8148870-10 1993 These results also suggest that the apparent discrepancy on the role of CYP forms in DZP metabolism in vitro and in vivo may reside in the difference in substrate concentration. Diazepam 85-88 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 72-75 2223898-0 1990 [Diazepam metabolism by multiple forms of cytochrome P-450 in rat liver microsomes]. Diazepam 1-9 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 42-58 2097287-1 1990 Among the benzodiazepines tested (diazepam, oxazepam, clonazepam, nitrazepam and chlordiazepoxide ) chlordiazepoxide is the most potent inducer of cytochrome P-450, diazepam is a poor inducer, whereas clonazepam and nitrazepam do not possess a capacity to induce of cytochrome P-450. Diazepam 34-42 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 147-163 6481217-1 1984 Cimetidine interaction with cytochrome P-450 may reduce binding affinity of some drugs, causing reduced metabolism of substrates such as diazepam and warfarin. Diazepam 137-145 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 28-44 1180618-4 1975 Although diazepam alone had no inducing effect, its use with ethanol increased the cytochrome P-450 content (56%) and the rate of metabolism of N-methylaniline (44%) more than ethanol alone. Diazepam 9-17 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 83-99