PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19428822-1	2009	The aim of the present investigation was to analyze the molecular mechanism(s) of diazepam neuroprotection in two models of selective neuronal death in CA1 sector of hippocampus: in vivo following transient gerbil brain ischemia and in vitro in rat hippocampal brain slices subjected to glutamatergic (100 microM NMDA) or oxidative (30 microM tertbutyl-hydroksyperoxide (TBH)) stress.	Diazepam	82-90	carbonic anhydrase 1	Rattus norvegicus	152-155	
19420124-5	2009	Typical of several drug classes and two cell types, in CA1 pyramidal neurons, the benzodiazepine diazepam doubled the total charge transfer (TCT) of miniature postsynaptic inhibitory currents (mIPSCs), whereas it quadrupled the TCT of tonic currents.	Diazepam	97-105	carbonic anhydrase 1	Rattus norvegicus	55-58	
19428822-7	2009	Next, we have shown that diazepam reduced the efflux of cytochrome c out of mitochondria both in compromised CA1 neurons in vitro and in isolated mitochondria treated with 30 microM THB.	Diazepam	25-33	carbonic anhydrase 1	Rattus norvegicus	109-112	
1286434-4	1992	Animals pretreated with diazepam (5 mg/kg, ip) tolerated intraventricular dose of domoic acid 0.4 microgram, but showed a loss of pyramidal neurons mainly in the CA3, CA4, and a part of CA1 areas of the dorsal hippocampus.	Diazepam	24-32	carbonic anhydrase 1	Rattus norvegicus	186-189	
18793683-0	2008	Diazepam attenuates the post-traumatic hyperactivity of excitatory synapses in rat hippocampal CA1 neurons.	Diazepam	0-8	carbonic anhydrase 1	Rattus norvegicus	95-98	
18793683-1	2008	The effect of diazepam, a benzodiazepine derivative, on the post-traumatic hyperactivity of excitatory synaptic transmission was examined in rat hippocampal CA1 area.	Diazepam	14-22	carbonic anhydrase 1	Rattus norvegicus	157-160	
18793683-12	2008	These results suggest that administration of diazepam at early post-traumatic period prevents the FPI-induced delayed enhancement of excitatory synaptic transmission in rat hippocampal CA1 neurons.	Diazepam	45-53	carbonic anhydrase 1	Rattus norvegicus	185-188	
11222088-4	2001	While bath application of muscimol, DZP, or baclofen suppressed spontaneous activity in CA1 neurons not previously exposed to TMPP, subsequent application of TMPP (10 microM) reversed the actions of muscimol and diazepam, but not baclofen.	Diazepam	36-39	carbonic anhydrase 1	Rattus norvegicus	88-91	
7823161-9	1995	In addition, diazepam prevented the loss of 35S-TBPS binding sites in the striatum and in the dendritic fields of the CA1 hippocampus following ischemia.	Diazepam	13-21	carbonic anhydrase 1	Rattus norvegicus	118-121	
7823161-11	1995	Diazepam was microinjected into the CA1 hippocampus 1 and 2 hr following ischemia, and rats remained normothermic.	Diazepam	0-8	carbonic anhydrase 1	Rattus norvegicus	36-39	
7907456-17	1993	It is demonstrated that administration of diazepam and GABA uptake inhibitors during this period offers postischemic neuron protection in CA1.	Diazepam	42-50	carbonic anhydrase 1	Rattus norvegicus	138-141	
14550784-0	2003	Extrasynaptic GABA(A) channels activated by THIP are modulated by diazepam in CA1 pyramidal neurons in the rat brain hippocampal slice.	Diazepam	66-74	carbonic anhydrase 1	Rattus norvegicus	78-81	
9421826-0	1997	Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia.	Diazepam	12-20	carbonic anhydrase 1	Rattus norvegicus	52-55	
7936097-9	1994	Diazepam (3 mg/kg) reduced the duration of the discharge and also reduced the amplitude of population spikes recorded in CA1.	Diazepam	0-8	carbonic anhydrase 1	Rattus norvegicus	121-124	
6640316-5	1983	Methyl-beta-carboline-3-carboxylate seems to have effects on the firing of CA1 neurons which are similar to the effects reported for ethyl-beta-carboline-3-carboxylate and opposite to those reported for the benzodiazepines midazolam and diazepam.	Diazepam	237-245	carbonic anhydrase 1	Rattus norvegicus	75-78	
1320683-0	1992	Reduction in potency of selective gamma-aminobutyric acidA agonists and diazepam in CA1 region of in vitro hippocampal slices from chronic flurazepam-treated rats.	Diazepam	72-80	carbonic anhydrase 1	Rattus norvegicus	84-87	
1656687-5	1991	Furthermore, we demonstrated that postischemic treatment with diazepam (4 x 15 mg/kg) significantly reduced the CA1 neuron loss.	Diazepam	62-70	carbonic anhydrase 1	Rattus norvegicus	112-115	
1705675-3	1990	The neuronal perikaryal death produced in the subicular, CA1 and CA2 regions was only partially decreased by intraperitoneal injections of the anticonvulsants diazepam and MK-801; these drugs were without effect in the CA3 or hilar interneuronal regions.	Diazepam	159-167	carbonic anhydrase 1	Rattus norvegicus	57-60	
25453777-10	2015	When NS-398 was administered with diazepam, decreased neuronal damage was further obtained in all areas investigated (CA1: 61%, CA3: 63%, hilus: 60%).	Diazepam	34-42	carbonic anhydrase 1	Rattus norvegicus	118-121	
25558239-0	2014	Effects of diazepam on glutamatergic synaptic transmission in the hippocampal CA1 area of rats with traumatic brain injury.	Diazepam	11-19	carbonic anhydrase 1	Rattus norvegicus	78-81	
25558239-5	2014	Diazepam effectively increased the paired-pulse facilitation ratio in the hippocampal CA1 region following fluid percussion injury, reduced miniature excitatory postsynaptic potentials, decreased action-potential-dependent glutamine release, and reversed spontaneous glutamine release.	Diazepam	0-8	carbonic anhydrase 1	Rattus norvegicus	86-89	
25558239-6	2014	These data suggest that diazepam could decrease the fluid percussion injury-induced enhancement of excitatory synaptic transmission in the rat hippocampal CA1 area.	Diazepam	24-32	carbonic anhydrase 1	Rattus norvegicus	155-158	
6138271-1	1983	Low intravenous doses of two benzodiazepines, lorazepam and diazepam, antagonized the activation of dorsal hippocampus CA1 pyramidal neurons by kainate to a greater extent than the activations produced by glutamate and acetylcholine.	Diazepam	60-68	carbonic anhydrase 1	Rattus norvegicus	119-122