PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10190045-5	1999	Enzyme inhibition studies showed that diazepam C3-hydroxylase of male rat liver was attributable to CYP3A but corresponding results for female rats suggested a contribution from non-CYP3A enzyme.	Diazepam	38-46	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	100-105	
10227577-5	1999	In human and rat liver, CYP3A isoforms have been implicated in mifepristone clearance and mifepristone administration to rats has also been shown to induce CYP3A enzymes and the associated diazepam C3-hydroxylase activity (Cheesman, Mason and Reilly, J.	Diazepam	189-197	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	24-29	
10190045-6	1999	Western blotting with immunochemical detection using anti-CYP3A4 IgG suggested the presence of putative CYP3A apoprotein in male and female crocodile liver samples and inhibition studies with diazepam as substrate suggested the presence of CYP3A subfamily monooxygenase activity in these enzyme preparations.	Diazepam	192-200	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	104-109	
8148870-2	1993	Microsomal 3-hydroxylation was the major pathway of DZP metabolism in rats and was inhibited by anti-CYP3A antibodies.	Diazepam	52-55	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	101-106	
8148870-8	1993	On the other hand, DZP 3-hydroxylation was rather selectively catalysed by a CYP3A P450 at the low and high substrate concentrations.	Diazepam	19-22	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	77-82	
8903430-5	1996	This confirms diazepam C3-hydroxylase as a useful and easily measured index of CYP3A monooxygenase content in female rat liver microsomes.	Diazepam	14-22	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	79-84	
17451291-9	1996	These results suggest that malaria infection and fever have no effect on the activities of the CYP3A isozymes thought to be involved in the metabolism of diazepam and ethosuximide.	Diazepam	154-162	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	95-100