PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6326115-7 1984 Since the diazepam-induced increase of [3H]muscimol binding is paralleled by a significant potentiation of the inhibitory effect of muscimol on locomotor activity, it is proposed that the facilitatory action on GABAergic transmission elicited in vivo by diazepam is mediated by an increase in the Bmax of the binding sites of GABAA receptors. Diazepam 10-18 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 326-331 2615592-1 1989 Previous studies suggest that a diazepam binding inhibitor (DBI, also referred to as endozepine) present in the brain may function anxiogenically as a modulator of the gamma-aminobutyric acid receptor complex (GABAA). Diazepam 32-40 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 210-215 32870779-6 2020 Lastly, we show the positive allosteric modulator diazepam enhanced GABA-A currents on dopaminergic axons and directly inhibited release, but also likely acts by reducing excitation from cholinergic interneurons. Diazepam 50-58 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 68-74 6140966-2 1983 The enhanced binding to GABAA and GABAB receptor sites and the decreased binding to benzodiazepine receptors was observed 24 hours after discontinuation of chronic treatment with diazepam (5 mg/kg, twice daily). Diazepam 179-187 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 24-29 31575739-0 2019 Photopotentiation of the GABAA receptor with caged diazepam. Diazepam 51-59 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 25-30 31575739-4 2019 No caged allosteric modulators of the GABAA receptor have been reported so far; to introduce such an investigational approach, we exploited the structural motifs of the benzodiazepinic scaffold to develop a photocaged version of diazepam (CD) that was tested on basolateral amygdala (BLa) pyramidal cells in mouse brain slices. Diazepam 229-237 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 38-43 25471569-12 2014 Using nonstationary fluctuation analysis and diazepam to manipulate GABAA receptor apparent affinity, the decrease in arcuate miniature postsynaptic current amplitude was attributed to decreased number of receptors bound by GABA. Diazepam 45-53 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 68-73 28426226-12 2017 The high brain uptake of oroxylin A, a GABAA antagonist which had been reported to antagonize diazepam-induced anxiolytic effect, might have suppressed the anxiolytic effects of the other flavones and account for the lack of overall anxiolytic effect of SR extract. Diazepam 94-102 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 39-44 26525567-9 2016 Allopregnanolone and diazepam similarly increased total entries in the elevated plus-maze, indicating that behavioral activation may be a general property of GABAA receptor PAMs in these strains. Diazepam 21-29 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 158-163 29163035-7 2017 Additionally, we identified Gabra genes as transcriptional targets of NPAS2, found that Npas2 null mutant mice exhibit reduced sensitivity to the GABAa positive allosteric modulator, diazepam and that knockdown of Npas2 reduced Gabra1 expression and response to diazepam in the ventral striatum. Diazepam 183-191 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 146-151 26612620-3 2016 OBJECTIVES: We tested the hypothesis that the GABAA receptor benzodiazepine-site (BDZ) negative modulator Ro15-4513 would reduce the reward-related effects of three pharmacologically dissimilar drugs; toluene vapor, d-methamphetamine, and diazepam using intracranial self-stimulation (ICSS) in mice. Diazepam 239-247 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 46-51 15304513-5 2004 Immunodepletion studies indicated that the His to Arg point mutation solely rendered those GABAA receptors totally insensitive to diazepam binding that contain two mutated alpha subunits in the receptor complex, whereas receptors containing one mutated and one heterologous alpha subunit not carrying the mutation remained sensitive to diazepam binding. Diazepam 336-344 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 91-96 23478657-15 2013 Functionally diazepam appeared to counteract the endogenous down-regulation of GABAA signaling during infection. Diazepam 13-21 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 79-84 23478657-16 2013 Consistent with augmented GABAA signaling, diazepam provoked intracellular acidosis in macrophage, leading to impaired cytokine production, bacterial phagocytosis and killing. Diazepam 43-51 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 26-31 19091469-0 2009 Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice. Diazepam 37-45 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 73-78 15304513-6 2004 This feature permitted a quantitative analysis of native GABAA receptors containing heterologous alpha subunits by comparing the diazepam-insensitive binding sites in mutant mouse lines containing one mutated alpha subunit with those present in mouse lines containing two different mutated alpha subunits. Diazepam 129-137 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 57-62 12716027-0 2003 Tolerance to diazepam-induced motor impairment: a study with GABAA receptor alpha6 subunit knockout mice. Diazepam 13-21 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 61-66 15341600-2 2004 Using mice, which carry a point mutation that renders specific subtypes of GABA A receptors diazepam insensitive, it was recently discovered that particular types of GABA A receptors are involved in specific, behaviorally relevant signaling pathways. Diazepam 92-100 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 75-81 15341600-2 2004 Using mice, which carry a point mutation that renders specific subtypes of GABA A receptors diazepam insensitive, it was recently discovered that particular types of GABA A receptors are involved in specific, behaviorally relevant signaling pathways. Diazepam 92-100 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 166-172 15341600-6 2004 Based on the different responses to diazepam, we found that IPSCs in the lateral/basolateral amygdala were mediated by both alpha2- and alpha1-subunit-containing GABA A receptors whereas those in the central amygdala were mediated only by alpha2-subunit-containing GABA A receptors. Diazepam 36-44 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 162-168 15341600-11 2004 Mice with specific diazepam-insensitive GABA A receptor subtypes therefore provide a novel tool to investigate GABA A receptor distribution and the organization of inhibitory circuits at a functional level. Diazepam 19-27 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 111-117 15007071-2 2004 Furthermore, the conductance of some native GABA(A) channels can be increased by diazepam or pentobarbital, which are effects not reported for expressed GABA(A) channels. Diazepam 81-89 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 44-51 15007071-2 2004 Furthermore, the conductance of some native GABA(A) channels can be increased by diazepam or pentobarbital, which are effects not reported for expressed GABA(A) channels. Diazepam 81-89 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 153-160 9385589-3 1997 Long-term treatment of mice with full allosteric modulator (triazolam 0.25 mg/kg/day for 8 days) or selective allosteric modulator (diazepam 20 mg/kg/day for 21 days) of GABAA receptor induced tolerance to behavioral sedation on actimeter and anxiolytic effects on plus-maze, and produced a marked withdrawal anxiety and hyperactivity syndrome upon abrupt cessation of treatment, respectively. Diazepam 132-140 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 170-175 11353839-0 2001 Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype. Diazepam 0-8 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 55-62 11353839-2 2001 BZs such as diazepam (Dz) potentiate GABA(A) receptor activation. Diazepam 12-20 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 37-44 11353839-2 2001 BZs such as diazepam (Dz) potentiate GABA(A) receptor activation. Diazepam 22-24 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 37-44 8886934-3 1996 Diazepam but not majonoside-R2 exhibited a protective activity against convulsion caused by the GABAA antagonists bicuculline and picrotoxin. Diazepam 0-8 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 96-101 8819520-13 1996 Other agents were less effective, which suggested a possible role for the diazepam-insensitive GABA-A sites that are recognized by Ro15-4513. Diazepam 74-82 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 95-101 8819520-14 1996 The failure of diazepam to suppress NK activity also suggests that increased chloride flux through diazepam-sensitive GABA-A receptors (which is caused by EtOH as well as diazepam) does not mediate NK suppression in this model. Diazepam 99-107 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 118-124 8819520-14 1996 The failure of diazepam to suppress NK activity also suggests that increased chloride flux through diazepam-sensitive GABA-A receptors (which is caused by EtOH as well as diazepam) does not mediate NK suppression in this model. Diazepam 99-107 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 118-124 8886934-4 1996 These results indicate that GABAA systems are involved in the effect of majonoside-R2 on the opioid-induced antinociception and suggest that the mechanisms of action of majonoside-R2 may differ from those of diazepam. Diazepam 208-216 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 28-33