PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31712706-12 2019 Partial pharmacological correction of gamma2-mediated IPSCs with diazepam restored total EEG power toward baseline, but had little effect on the abnormal low-frequency peak in the EEG. Diazepam 65-73 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 38-44 33014431-7 2020 Furthermore, treatment with low-dose diazepam (a positive allosteric modulator of GABAA receptors), which enhances GABAAR function, also markedly ameliorates severity of epileptic seizures in ALG13KO mice. Diazepam 37-45 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 115-121 25466558-9 2014 Surprisingly, the positive allosteric modulator diazepam abolished the regulation induced by muscimol, and this effect was observed on alpha1, alpha2, alpha5 and gamma2 GABA(A)R subunits. Diazepam 48-56 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 169-177 31080408-5 2019 In contrast, both gamma2 and the postsynaptic scaffolding protein gephyrin showed diminished total protein levels following a single DZP treatment in vitro and in mouse cortical tissue. Diazepam 133-136 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 18-24 31080408-7 2019 Selective immunoprecipitation of gamma2 from cultured neurons revealed enhanced ubiquitination of this subunit following DZP exposure. Diazepam 121-124 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 33-39 31080408-12 2019 Moreover, we found DZP simultaneously enhanced synaptic exchange of both gamma2-GABAARs and gephyrin using fluorescence recovery after photobleaching (FRAP) techniques. Diazepam 19-22 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 73-79 31080408-13 2019 Finally we provide the first proteomic analysis of the BZD sensitive GABAAR interactome in DZP vs. vehicle treated mice. Diazepam 91-94 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 69-75 31080408-14 2019 Collectively, our results indicate DZP exposure elicits down-regulation of gephyrin scaffolding and BZD sensitive GABAAR synaptic availability via multiple dynamic trafficking processes. Diazepam 35-38 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 114-120 31080408-0 2019 Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking. Diazepam 0-8 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 21-27 25466558-10 2014 Altogether these results indicate that diazepam stabilizes synaptic GABA(A)Rs and thus prevents the agonist-induced regulation of GABA(A)R levels at synapses. Diazepam 39-47 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 68-76 20412381-3 2010 The alpha subunit affects diazepam sensitivity; alpha1, 2, 3, and 5 subunits assemble with any form of beta and the gamma2 subunits to produce diazepam-sensitive receptors, whereas alpha4 or alpha6/beta/gamma2 receptors are diazepam-insensitive. Diazepam 143-151 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 116-122 20412381-9 2010 PRIP-1 and 2 double KO mice exhibit a diazepam-insensitive phenotype because of a decrease in diazepam-sensitive (alpha1/gamma2) and increase in diazepam-insensitive (alpha6/gamma2) GABA(A) receptors in the cerebellar granule cells. Diazepam 94-102 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 114-127 20412381-9 2010 PRIP-1 and 2 double KO mice exhibit a diazepam-insensitive phenotype because of a decrease in diazepam-sensitive (alpha1/gamma2) and increase in diazepam-insensitive (alpha6/gamma2) GABA(A) receptors in the cerebellar granule cells. Diazepam 94-102 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 114-127 16537521-2 2006 Behaviorally, socially isolated (SI) mice are resistant to the sedative effects of the positive allosteric GABA(A)-R modulators diazepam (DZP) and zolpidem. Diazepam 128-136 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 107-116 16537521-2 2006 Behaviorally, socially isolated (SI) mice are resistant to the sedative effects of the positive allosteric GABA(A)-R modulators diazepam (DZP) and zolpidem. Diazepam 138-141 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 107-116 24531568-4 2014 OBJECTIVES: In the current study, we examined whether subchronic zolpidem or diazepam administration produced deficits in zolpidem"s locomotor-impairing effects, anxiety-like behaviors, and changes in GABAAR subunit messenger RNA (mRNA). Diazepam 77-85 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 201-207 24531568-9 2014 In addition, we found that subchronic treatment of zolpidem and diazepam induced distinct but overlapping GABAAR subunit mRNA changes in the cortex but few changes in the hippocampus, amygdala, or prefrontal cortex. Diazepam 64-72 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus 106-112