PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33156577-2 2021 Our recent in vitro studies defined the functional fingerprint of heteromers composed of Gi -coupled melatonin MT2 receptors and Gq -coupled serotonin 5-HT2C receptors, in which melatonin transactivates phospholipase C (PLC) through 5-HT2C . Serotonin 141-150 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 151-157 33441874-7 2021 A significant upregulation of serotonin receptors, Htr2a and Htr2c, was observed in the bladders from mice with constipation, paralleled with augmented spontaneous contractions after pre-incubation of the bladder strips with 0.5 microM of serotonin. Serotonin 30-39 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 61-66 33441874-7 2021 A significant upregulation of serotonin receptors, Htr2a and Htr2c, was observed in the bladders from mice with constipation, paralleled with augmented spontaneous contractions after pre-incubation of the bladder strips with 0.5 microM of serotonin. Serotonin 239-248 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 61-66 31786274-1 2020 Pharmacological studies have suggested that the serotonin 5-HT2C receptor is involved in locomotor activity, anxiety, and fear memory. Serotonin 48-57 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 58-73 33016258-1 2020 SNORD115 has been proposed to promote the activity of serotonin (HTR2C) receptor via its ability to base-pair with its pre-mRNA and regulate alternative RNA splicing and/or A-to-I RNA editing. Serotonin 54-63 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 65-70 31987863-2 2020 Lorcaserin is a serotonin 5-HT2C receptor (5-HT2CR) agonist that has recently been reported to reduce abuse-related effects of the opioid analgesic oxycodone. Serotonin 16-25 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 43-50 26248536-5 2016 Additionally, prior stress increased amygdala sensitivity to serotonin by promoting surface expression of 5-HT2CR without affecting tissue levels of serotonin in the amygdala. Serotonin 61-70 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 106-113 31647782-7 2019 Instead, activation of the 5HT2C receptor by serotonin treatment led to activation of IP3-sensitive channels and Ca2+ mobilization from intracellular storage, leading to insulin secretion. Serotonin 45-54 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 27-41 30243647-13 2018 SIGNIFICANCE: According to these results, it may be suggested that curcumin exerts anticonvulsive effects by increasing the serotonin levels in the brain that influence receptors, including 5-HT1A, 5-HT2C, and 5-HT4 and likely through the reduction of 5-HT7 gene expression. Serotonin 124-133 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 198-204 27189964-8 2016 By single-cell calcium imaging, we found that serotonin and WAY-161,503 induced robust calcium transients, which were also blunted by both 5-HT2CR antagonists. Serotonin 46-55 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 139-146 27189964-9 2016 Additionally we revealed, first, that 5-HT2CR induced CRE activation via protein kinase C (PKC)-mediated engagement of extracellular-regulated kinases-1/2 and, second, that intrinsic activity of WAY-161,503 was in the range of 0.3-0.5 compared with serotonin, defining the frequently used 5-HT2CR agonist as a partial agonist of endogenous 5-HT2CR. Serotonin 249-258 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 38-45 28126736-4 2017 These changes were accompanied by elevated levels of editing at the D site of the serotonin (5-hydroxytryptamine) 2C receptor (5-HT2CR), at the I/V site of coatomer protein complex subunit alpha (COPA), and at the R/G site of AMPA receptor subunit GluA2 in the injured DRG. Serotonin 82-91 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 127-134 27931246-1 2016 Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT2CR) pre-RNA is negatively regulated by the small nucleolar RNA, Snord115, loss of which is observed in nearly all individuals with Prader-Willi Syndrome (PWS), a multigenic disorder characterised by hyperphagia and obesity. Serotonin 22-31 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 73-80 27931246-1 2016 Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT2CR) pre-RNA is negatively regulated by the small nucleolar RNA, Snord115, loss of which is observed in nearly all individuals with Prader-Willi Syndrome (PWS), a multigenic disorder characterised by hyperphagia and obesity. Serotonin 33-52 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 73-80 27282784-5 2016 Alterations in 5-HT2A and 5-HT2C receptors explain the increase of the response to serotonin in TLR2(-/-) mice. Serotonin 83-92 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 26-32 27282784-6 2016 Alterations in 5-HT2C and 5-HT4 receptors explain the suppression of the response to serotonin in TLR4(-/-) mice. Serotonin 85-94 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 15-21 23103406-1 2013 Previous studies have identified an inhibitory regulatory role of the 5-HT(2C) receptor in serotonin and dopamine neurotransmission. Serotonin 91-100 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 70-87 23583320-1 2013 This study was conducted to clarify the role of serotonin (5-hydroxytryptamine, 5-HT) 2C receptor (5-HT2CR) signaling during novelty-induced hypophagia in aged mice. Serotonin 48-57 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 99-106 25656481-1 2015 The serotonin system is intimately linked to both the mediation of anxiety and long-term effects of cocaine, potentially through interaction of inhibitory 5-HT2C receptor and gamma-aminobutyric acid (GABA) networks. Serotonin 4-13 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 155-170 23353901-1 2013 There are seemingly conflicting data in the literature regarding the role of serotonin (5-HT) 5-HT2C receptors in the mouse head-twitch response (HTR) elicited by the hallucinogenic 5-HT2A/2B/2C receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI). Serotonin 77-86 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 94-100 22436698-8 2012 To determine if serotonin suppresses the M-current via the 5-HT(2C) receptor, we examined the effects of the 5-HT(2A)/5-HT(2C) receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) on the M-current. Serotonin 16-25 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 59-76 22886598-1 2012 In this paper, we report the discovery and the synthesis of novel, potential antipsychotic piperidine-2,6-dione derivatives combining potent dopamine D(2) , D(3) and serotonin 5-HT(1A) , 5-HT(2A) , 5-HT(2C) receptor properties. Serotonin 167-176 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 199-217 22448217-2 2012 Serotonin exerts its anorectic effects mainly through the 5-HT(1B), 5-HT(2C) and 5-HT(6) receptors and these are therefore receiving increasing attention as principal pharmacotherapeutic targets for the treatment of obesity. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 68-75 21648199-3 2011 Serotonin-related genes that are found in OCD include those coding for the 5-HT transporter (5-HTT) and receptors (5-HT(2A), 5-HT(2B), 5-HT(2C) and 5-HT(1B)) as well the 5-HT enzyme tryptophan hydroxylase. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 135-142 21615684-1 2011 Modulation of serotonin signaling by RNA editing of the serotonin 2C receptor (5HT(2C) R) may be relevant to affective disorder as serotonin functions regulate mood and behavior. Serotonin 14-23 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 79-85 21615684-1 2011 Modulation of serotonin signaling by RNA editing of the serotonin 2C receptor (5HT(2C) R) may be relevant to affective disorder as serotonin functions regulate mood and behavior. Serotonin 56-65 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 79-85 20181818-5 2010 Our method is based on the serotonin 2C receptor (5-hydroxytryptamine(2C); 5HT(2C)) transcript, an RNA editing substrate in which up to five adenosines are modified. Serotonin 50-69 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 75-81 20952540-4 2010 In contrast, we do not know how brain-derived serotonin favors bone mass accrual following its binding to the Htr2c receptor on neurons of the hypothalamic ventromedial nucleus (VMH). Serotonin 46-55 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 110-115 20952540-5 2010 We show here--through gene expression analysis, serotonin treatment of wild-type and Htr2c(-/-) hypothalamic explants, and cell-specific gene deletion in the mouse--that, following its binding to the Htr2c receptor on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade involving CaMKKbeta and CaMKIV to decrease the sympathetic tone and increase bone mass accrual. Serotonin 48-57 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 85-90 20952540-5 2010 We show here--through gene expression analysis, serotonin treatment of wild-type and Htr2c(-/-) hypothalamic explants, and cell-specific gene deletion in the mouse--that, following its binding to the Htr2c receptor on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade involving CaMKKbeta and CaMKIV to decrease the sympathetic tone and increase bone mass accrual. Serotonin 48-57 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 200-205 20952540-5 2010 We show here--through gene expression analysis, serotonin treatment of wild-type and Htr2c(-/-) hypothalamic explants, and cell-specific gene deletion in the mouse--that, following its binding to the Htr2c receptor on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade involving CaMKKbeta and CaMKIV to decrease the sympathetic tone and increase bone mass accrual. Serotonin 231-240 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 85-90 20952540-5 2010 We show here--through gene expression analysis, serotonin treatment of wild-type and Htr2c(-/-) hypothalamic explants, and cell-specific gene deletion in the mouse--that, following its binding to the Htr2c receptor on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade involving CaMKKbeta and CaMKIV to decrease the sympathetic tone and increase bone mass accrual. Serotonin 231-240 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 200-205 12934707-4 2003 Studies on mice revealed that 5-HT2C pre-mRNA editing is regulated in a serotonin-dependent manner, and postmortem studies on brain tissues of patients with schizophrenia and major depression found distinct site-specific alterations of this editing in the prefrontal cortex, a brain region expressing a large number of differently edited 5-HT2C mRNA isoforms. Serotonin 72-81 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 30-36 15659601-3 2005 However, in the BALB/c strain, a genetically distinct inbred strain with lower forebrain serotonin levels, spontaneously elevated anxiety, and increased stress reactivity, the majority of 5-HT2C mRNA is nonedited and encodes receptors with the highest constitutive activity and the highest agonist affinity and potency. Serotonin 89-98 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 188-194 19036977-1 2008 RNA editing that converts adenosine to inosine replaces the gene-encoded Ile, Asn, and Ile (INI) of serotonin [5-hydroxytryptamine (5-HT)] receptor 2C (5-HT(2C)R) with Val, Gly, and Val (VGV). Serotonin 100-109 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 152-161 19036977-1 2008 RNA editing that converts adenosine to inosine replaces the gene-encoded Ile, Asn, and Ile (INI) of serotonin [5-hydroxytryptamine (5-HT)] receptor 2C (5-HT(2C)R) with Val, Gly, and Val (VGV). Serotonin 111-130 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 152-161 18477467-0 2008 Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 70-76 17637084-7 2007 Serotonergic neurons originating in the raphe nuclei and glucagon-like peptide-1-expressing neurons in the hindbrain may be among the targets of these messengers, because serotonin (5-HT), acting through the 5-HT2C receptor, and glucagon-like peptide-1 have recently emerged as neurochemical mediators of LPS anorexia. Serotonin 171-180 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 208-223 15138437-7 2004 The potentiation of SSRI-induced increases in hippocampal serotonin levels was reproduced by the 5-HT(2C) receptor-selective antagonists SB 242084 and RS 102221, but not by the 5-HT(2A) receptor-selective antagonist MDL 100 907. Serotonin 58-67 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 97-114 12682077-10 2003 Next, serotonin treatment of 5-HT2C R/3T3 cells resulted in a dose-dependent reduction of receptor interaction with PDZ 10. Serotonin 6-15 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 29-35 34921828-0 2022 A selective serotonin reuptake inhibitor ameliorates obsessive-compulsive disorder-like perseverative behavior by attenuating 5-HT2C receptor signaling in the orbitofrontal cortex. Serotonin 12-21 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 126-141 10514821-5 1999 Here, we briefly describe the techniques of random transgene insertion and gene targeting and discuss how these methods were used to generate the epileptic jerky and 5-hydroxytryptamine (5-HT2C) receptor deficient mice. Serotonin 166-185 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 187-203 9769705-13 1998 Both serotonin, acting through 5-HT2C receptors, and norepinephrine, acting through beta 2 and/or beta 3 receptors, reduce food intake. Serotonin 5-14 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 31-37 8626761-5 1996 Serotonin increased APPs release 3-4-fold in 3T3 cells stably overexpressing 5-HT2aR or 5-HT2cR. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 88-95 7700379-4 1995 To address these issues, we have generated mutant mice lacking functional 5-HT2C receptors (previously termed 5-HT1C), prominent G-protein-coupled receptors that are widely expressed throughout the brain and spinal cord and which have been proposed to mediate numerous central nervous system (CNS) actions of serotonin. Serotonin 309-318 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 74-80 7700379-4 1995 To address these issues, we have generated mutant mice lacking functional 5-HT2C receptors (previously termed 5-HT1C), prominent G-protein-coupled receptors that are widely expressed throughout the brain and spinal cord and which have been proposed to mediate numerous central nervous system (CNS) actions of serotonin. Serotonin 309-318 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 110-116 12486144-3 2002 Nucleotide sequence analysis of mouse forebrain neocortical 5-HT2C mRNA isoforms revealed that editing at these two sites is regulated in a serotonin-dependent manner. Serotonin 140-149 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 60-66 12486144-5 2002 This results in an increased expression of 5-HT2C mRNA isoforms encoding receptors with higher sensitivity to serotonin. Serotonin 110-119 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 43-49 12231467-1 2002 Stimulation of serotonin receptor subtypes 5-HT(2A) or 5-HT(2C) in stably transfected 3T3 cells by dexnorfenfluramine (DEXNOR) or serotonin increases secretion of the APP metabolite APP(s). Serotonin 130-139 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 55-62 1899581-3 1991 When the K+ channel was coexpressed with a cloned mouse brain serotonin receptor (5HT1c) in oocytes, activation of the 5HT1c receptor by a brief application of serotonin resulted in a suppression of the IK amplitude over the next 20 min. Serotonin 62-71 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 82-87 1899581-3 1991 When the K+ channel was coexpressed with a cloned mouse brain serotonin receptor (5HT1c) in oocytes, activation of the 5HT1c receptor by a brief application of serotonin resulted in a suppression of the IK amplitude over the next 20 min. Serotonin 62-71 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 119-124 34547341-1 2022 The monoamine neurotransmitter serotonin (5-HT) modulates anxiety by its activity on 5-HT2C receptors (5-HT2CR) expressed in the dorsal periaqueductal gray (dPAG). Serotonin 31-40 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 85-101 34547341-1 2022 The monoamine neurotransmitter serotonin (5-HT) modulates anxiety by its activity on 5-HT2C receptors (5-HT2CR) expressed in the dorsal periaqueductal gray (dPAG). Serotonin 31-40 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 103-110 34547341-1 2022 The monoamine neurotransmitter serotonin (5-HT) modulates anxiety by its activity on 5-HT2C receptors (5-HT2CR) expressed in the dorsal periaqueductal gray (dPAG). Serotonin 42-46 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 85-101 34547341-1 2022 The monoamine neurotransmitter serotonin (5-HT) modulates anxiety by its activity on 5-HT2C receptors (5-HT2CR) expressed in the dorsal periaqueductal gray (dPAG). Serotonin 42-46 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 103-110 34547341-7 2022 The present results suggest that the anxiolytic-like effect exerted by serotonin activity on 5-HT2CR in the dPAG is modulated by 5-HT3AR expressed in same region. Serotonin 71-80 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 93-100 34837227-0 2022 A new class of serotonin 5-HT2A /5-HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2-aminotetralins. Serotonin 15-24 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 33-48 34788630-0 2021 Galphai/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents. Serotonin 111-120 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 18-23 34396109-5 2021 Accordingly, the G protein-coupled, membrane serotonin receptor 5-HT2C inhibits forebrain and brainstem networks by exciting GABAergic interneurons, and deletion of this gene lowers the threshold for lethal evoked audiogenic seizures. Serotonin 45-54 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 64-70