PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9539397-9 1998 The effect on the pituitary-adrenal-axis by depressive disorders and changes in serotonin metabolism have been investigated repeatedly; mainly reported are increased levels of corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) in the depressive interval, which may lead to a growth of the adrenal glands. Serotonin 80-89 proopiomelanocortin Homo sapiens 218-245 10071178-3 1999 In mentally retarded subjects, several hypotheses have been formulated concerning the pathogenesis of SIB, particularly about the involvement of serotonin and beta-endorphin, which are supported by beneficial treatment effects of the opiate antagonist naltrexone and serotonin modulating compounds, respectively. Serotonin 267-276 proopiomelanocortin Homo sapiens 159-173 9171947-3 1997 We aimed to investigate this hypothesis by measuring the effect of the highly specific serotonin re-uptake inhibitor fluoxetine (FX) on ACTH and cortisol release in the morning and in the afternoon in humans, both by itself and in combination with the opioid antagonist naloxone (Nal). Serotonin 87-96 proopiomelanocortin Homo sapiens 136-140 9385755-2 1997 In the patient group, pressure pain threshold values were related to the blood cell concentration of some neurotransmitters which are considered to be involved in the genesis and modulation of pain (beta-endorphin levels in peripheral blood mononuclear cells [PBMCs], substance P and serotonin concentrations in platelets). Serotonin 284-293 proopiomelanocortin Homo sapiens 199-213 8880051-6 1996 CONCLUSION: Our results indicate that in humans serotonin-evoked stimulation of ACTH secretion is not mediated through serotonin4 (5-HT4) receptors. Serotonin 48-57 proopiomelanocortin Homo sapiens 80-84 8917909-2 1996 Generally, in anestrous ewes beta-endorphin and/or corticoliberin significantly change extracellular concentrations of monoamine metabolites in the MBH-ME, but in estrous ewes both beta-endorphin and CRF alters also dopamine, noradrenaline and serotonin levels. Serotonin 244-253 proopiomelanocortin Homo sapiens 29-43 8917909-2 1996 Generally, in anestrous ewes beta-endorphin and/or corticoliberin significantly change extracellular concentrations of monoamine metabolites in the MBH-ME, but in estrous ewes both beta-endorphin and CRF alters also dopamine, noradrenaline and serotonin levels. Serotonin 244-253 proopiomelanocortin Homo sapiens 181-195 7883264-4 1995 The liberation of CRH and ACTH is stimulated by the appetite suppressant, serotonin, and inhibited by the appetite-stimulating antagonist cyproheptadine and by glucocorticoids. Serotonin 74-83 proopiomelanocortin Homo sapiens 26-30 8637392-2 1996 A variety of drugs including precursors of 5HT such as 5HTP, drugs which release 5HT such as fenfluramine and drugs which act directly on 5HT receptors such as ipsapirone increase cortisol and ACTH concentrations. Serotonin 43-46 proopiomelanocortin Homo sapiens 193-197 8637392-2 1996 A variety of drugs including precursors of 5HT such as 5HTP, drugs which release 5HT such as fenfluramine and drugs which act directly on 5HT receptors such as ipsapirone increase cortisol and ACTH concentrations. Serotonin 55-58 proopiomelanocortin Homo sapiens 193-197 7520295-9 1993 beta-endorphin, which may be the "missing link" between the neuron and the wall of the arteriole, must be considered as being a fundamental neurotransmitter in the same way as well-known substances such as noradrenaline, acetylcholine, serotonin, dopamine and the GABAergic system are also neurotransmitters. Serotonin 236-245 proopiomelanocortin Homo sapiens 0-14 7831445-3 1993 Furthermore, clozapine, in contrast to conventional neuroleptics, blocks the effect of 5HT agonists on ACTH and corticosterone release in animals. Serotonin 87-90 proopiomelanocortin Homo sapiens 103-107 7831445-4 1993 This study hypothesized that clozapine, but not haloperidol would block ACTH and prolactin release induced by the 5HT agonist, m-chlorophenylpiperazine (MCPP). Serotonin 114-117 proopiomelanocortin Homo sapiens 72-76 1334001-7 1992 Measurement of ACTH or cortisol levels in humans after administration of a direct- or indirect-acting serotonin agonist provides one means of probing the functional state of brain serotonergic systems in disease or after drug treatment. Serotonin 102-111 proopiomelanocortin Homo sapiens 15-19 1410142-1 1992 It has been demonstrated convincingly that ACTH and prolactin release are under the stimulatory control of serotonin (5-hydroxytryptamine, 5HT). Serotonin 107-116 proopiomelanocortin Homo sapiens 43-47 1410142-1 1992 It has been demonstrated convincingly that ACTH and prolactin release are under the stimulatory control of serotonin (5-hydroxytryptamine, 5HT). Serotonin 118-137 proopiomelanocortin Homo sapiens 43-47 1410142-1 1992 It has been demonstrated convincingly that ACTH and prolactin release are under the stimulatory control of serotonin (5-hydroxytryptamine, 5HT). Serotonin 139-142 proopiomelanocortin Homo sapiens 43-47 1724602-8 1991 These data demonstrate that the presence of seizures in infantile spasms is associated with a significant decrease in serotonergic activity and that elimination of seizures by ACTH is accompanied by increased serotonin turnover. Serotonin 209-218 proopiomelanocortin Homo sapiens 176-180 2143059-6 1990 In rat, the serotonin receptor antagonist metergoline decreased basal concentrations of the opioid peptide and blocked the increase of beta-endorphin concentrations induced by the serotonin precursor 5-hydroxytryptophan and the tricyclic antidepressant chlorimipramine. Serotonin 12-21 proopiomelanocortin Homo sapiens 135-149 1650487-1 1991 The present study reports adrenocorticotropic hormone (ACTH) and prolactin responses after oral administration of 0.25 mg/kg of the serotonin agonist, meta-chlorophenylpiperazine (MCPP), in patients with panic disorder (PD) and in healthy subjects. Serotonin 132-141 proopiomelanocortin Homo sapiens 26-53 2175252-9 1990 ACTH-like peptide in the brain may act as a neuromodulator, mainly in the NLT and the preoptic nucleus, and around the nuclei of the ventricular recesses containing serotonin and catecholamines. Serotonin 165-174 proopiomelanocortin Homo sapiens 0-4 2259242-1 1990 Increasing brain 5-hydroxytryptamine (5-HT) function in humans raises plasma concentrations of prolactin, growth hormone and ACTH. Serotonin 17-36 proopiomelanocortin Homo sapiens 125-129 2156665-1 1990 Sensitivity of blood lymphocytes to the stimulating effect of met-enkephalin and dopamine was shown to decrease at late stages of the gastric cancer (IIIB-IV) or in the case of metastases to other organs, while to the inhibitory effect of serotonin it increased as compared to early stages (I-IIA). Serotonin 239-248 proopiomelanocortin Homo sapiens 62-76 2546129-1 1989 The capacity of the serotonin (5-HT) precursor 5-HIP to induce the ACTH-responsive myoclonic-convulsive disorder infantile spasms in patients with Down"s syndrome has been cited as evidence for altered serotonergic neurotransmission in infantile spasms. Serotonin 20-29 proopiomelanocortin Homo sapiens 67-71 2548898-5 1989 Met-enkephalin infused into the vascular bed of an isolated portion of the intestine (0.01-5.0 micrograms/ml/min), potentiated the colon and ileocecal sphincter responses to acetylcholine (1.0-20.0 micrograms), the colon responses to stimulation of the n. vagus efferent fibers, and the ileocecal sphincter responses to serotonin (20-100 micrograms). Serotonin 320-329 proopiomelanocortin Homo sapiens 0-14 2537340-8 1989 These results support the hypothesis that serotonin is involved in the regulation of PRL, cortisol, and ACTH in humans. Serotonin 42-51 proopiomelanocortin Homo sapiens 104-108 2571183-5 1989 The stimulatory influence of norepinephrine, serotonin, and acetylcholine on the secretion of corticotropin (ACTH) in rodents and man will be discussed, whereas GABA exerts an inhibitory effect on the secretion of ACTH in both man and rodents. Serotonin 45-54 proopiomelanocortin Homo sapiens 109-113 2856056-0 1988 Inhibition of serotonin-induced ACTH release in man by clonidine. Serotonin 14-23 proopiomelanocortin Homo sapiens 32-36 2963016-1 1988 Circulating beta-endorphin (beta EP) and beta-lipotropin (beta LPH) concentrations increase after the administration of acetylcholine or serotonin agonist drugs. Serotonin 137-146 proopiomelanocortin Homo sapiens 12-26 2963016-1 1988 Circulating beta-endorphin (beta EP) and beta-lipotropin (beta LPH) concentrations increase after the administration of acetylcholine or serotonin agonist drugs. Serotonin 137-146 proopiomelanocortin Homo sapiens 28-35 2963016-1 1988 Circulating beta-endorphin (beta EP) and beta-lipotropin (beta LPH) concentrations increase after the administration of acetylcholine or serotonin agonist drugs. Serotonin 137-146 proopiomelanocortin Homo sapiens 58-66 2449537-6 1987 However, if, prior to nerve resection, serotonin stores are depleted by p-chlorophenylalanine treatment, the damage to met-enkephalin interneurons is fully prevented, while substance P loss does still occur. Serotonin 39-48 proopiomelanocortin Homo sapiens 119-133 2881720-0 1987 Injections of alpha-melanocyte stimulating hormone affect pineal serotonin, melatonin and N-acetyltransferase activity. Serotonin 65-74 proopiomelanocortin Homo sapiens 14-50 2881720-2 1987 The low dose of alpha-MSH (200 ng) produced a significant fall in pineal serotonin, pineal NAT activity and plasma prolactin values. Serotonin 73-82 proopiomelanocortin Homo sapiens 16-25 2957299-8 1987 These data confirm that serotonin-acting drugs are able to stimulate POMC-related peptide release and indicate that such interaction is not mediated through S2 receptor subclass. Serotonin 24-33 proopiomelanocortin Homo sapiens 69-73 3158643-5 1985 Serotonin levels were positively correlated with levels of beta-endorphin and negatively correlated to epinephrine. Serotonin 0-9 proopiomelanocortin Homo sapiens 59-73 2868517-3 1985 At the pituitary level, alpha-MSH secretion is under multifactorial control: it is inhibited by dopamine and GABA and stimulated by corticoliberin (CRF), thyroliberin (TRH), beta-adrenergic agonists and (or) serotonin. Serotonin 208-217 proopiomelanocortin Homo sapiens 24-33 6092410-2 1984 Acute administration of L5-OH-triptophan, the physiologic precursor of serotonin (SE), induced a significant rise in plasma beta-EP and beta-LPH levels both when injected iv (20 and 40 mg) (four normal men) and when administered orally (200 and 400 mg) (seven normal men) (P less than 0.01 vs. placebo). Serotonin 71-80 proopiomelanocortin Homo sapiens 124-131 6092410-2 1984 Acute administration of L5-OH-triptophan, the physiologic precursor of serotonin (SE), induced a significant rise in plasma beta-EP and beta-LPH levels both when injected iv (20 and 40 mg) (four normal men) and when administered orally (200 and 400 mg) (seven normal men) (P less than 0.01 vs. placebo). Serotonin 71-80 proopiomelanocortin Homo sapiens 136-144 6089950-1 1984 A study was performed to see whether ketanserin, a serotonin antagonist, would reduce the raised concentrations of adrenocorticotrophic hormone (ACTH) in patients with Nelson"s syndrome. Serotonin 51-60 proopiomelanocortin Homo sapiens 145-149 6089950-4 1984 In healthy people serotonin seems to have a stimulatory role in the regulation of ACTH secretion, and the effect of ketanserin in reducing the ACTH response to hypoglycaemia suggested that it might prove useful in Nelson"s syndrome. Serotonin 18-27 proopiomelanocortin Homo sapiens 82-86 6203623-5 1984 Similar serotonin binding sites were found to exist on LHRH (Tyr Ser Trp) and MSH-ACTH tetrapeptide (Phe Arg Trp). Serotonin 8-17 proopiomelanocortin Homo sapiens 78-81 6203623-5 1984 Similar serotonin binding sites were found to exist on LHRH (Tyr Ser Trp) and MSH-ACTH tetrapeptide (Phe Arg Trp). Serotonin 8-17 proopiomelanocortin Homo sapiens 82-86 6325044-7 1984 These findings suggest that serotonin, probably acting through 5HT2 receptors, is involved in the stimulation of prolactin and ACTH release but not in the release of growth hormone, during insulin induced hypoglycaemia. Serotonin 28-37 proopiomelanocortin Homo sapiens 127-131 6317143-1 1983 The relative role of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) in mediating serotonin-induced ACTH secretion was studied using the serotonin reuptake inhibitor fluoxetine. Serotonin 102-111 proopiomelanocortin Homo sapiens 120-124 6243668-7 1980 Review of the literature suggests the possibility that ACTH stimulation only occurs at high plasma tryptophan (and presumably brain serotonin) concentrations, with ACTH inhibition occuring at lower levels. Serotonin 132-141 proopiomelanocortin Homo sapiens 55-59 6203623-8 1984 Structural and functional similarities between the tryptophan peptide, LHRH, and MSH-ACTH with an ACTH-like peptide of human leukocyte interferon, with human and bovine serum albumin, hen ovalbumin, and with red pigment concentrating hormone suggest that the latter peptides may also contain similar serotonin binding sites. Serotonin 300-309 proopiomelanocortin Homo sapiens 81-84 6203623-8 1984 Structural and functional similarities between the tryptophan peptide, LHRH, and MSH-ACTH with an ACTH-like peptide of human leukocyte interferon, with human and bovine serum albumin, hen ovalbumin, and with red pigment concentrating hormone suggest that the latter peptides may also contain similar serotonin binding sites. Serotonin 300-309 proopiomelanocortin Homo sapiens 85-89 6306711-2 1983 Since zimelidine is a relatively selective serotonin reuptake inhibitor its action on hypothalamic-pituitary-adrenal (HPA) activity suggests that serotonin is a potent stimulator of ACTH release. Serotonin 146-155 proopiomelanocortin Homo sapiens 182-186 6295736-1 1982 Serotonin is involved in the control of ACTH secretion, possibly by stimulating corticotropin releasing factor secretion from the hypothalamus. Serotonin 0-9 proopiomelanocortin Homo sapiens 40-44 6174697-0 1982 Serotonin and gamma-aminobutyric acid turnover after injection into the median raphe of substance P and D-ala-met-enkephalin amide. Serotonin 0-9 proopiomelanocortin Homo sapiens 110-124 6262849-0 1981 beta-Endorphin-induced release of 5-hydroxytryptamine from human platelets. Serotonin 34-53 proopiomelanocortin Homo sapiens 0-14 528041-2 1979 It was suggested that hypo or low normal function of thyroid might facilitate excess elaboration of ACTH through CRF by swaying the balance of neurotransmitters at hypothalamus in favour of serotonin. Serotonin 190-199 proopiomelanocortin Homo sapiens 100-104 224071-5 1979 In the thymic tumor cells, norepinephrine, serotonin, and TRH were found to be effective in increasing ACTH secretion and intracellular cAMP levels, whereas biogenic amines, hypothalamic hormones, and gastrointestinal hormones did not affect hormone secretion in the thyroid tumor cells. Serotonin 43-52 proopiomelanocortin Homo sapiens 103-107 211917-0 1977 Serotonin regulation of ACTH secretion. Serotonin 0-9 proopiomelanocortin Homo sapiens 24-28 313251-0 1979 Effect of serotonin on prolactin- and MSH-secreting cells in the eel. Serotonin 10-19 proopiomelanocortin Homo sapiens 38-41 743624-0 1978 Alterations in brain dopamine and serotonin metabolism during the development of tolerance to human beta-endorphin in rats. Serotonin 34-43 proopiomelanocortin Homo sapiens 100-114 743624-2 1978 The initial injection of beta-endorphin results in increases in the dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in neostriatum, as well as increases in the serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in hypothalamus and brainstem and a decrease in 5-HIAA in hippocampus. Serotonin 202-211 proopiomelanocortin Homo sapiens 25-39 743624-3 1978 In the present study, we report changes in metabolism of dopamine and serotonin in specific brain areas during the development of tolerance to beta-endorphin. Serotonin 70-79 proopiomelanocortin Homo sapiens 143-157 743624-4 1978 Thus, the development of tolerance to beta-endorphin with respect to catalepsy, analgesia, and hypothermia may be mediated by development of tolerance to the effects of beta-endorphin on brain dopamine and serotonin release. Serotonin 206-215 proopiomelanocortin Homo sapiens 38-52 743624-4 1978 Thus, the development of tolerance to beta-endorphin with respect to catalepsy, analgesia, and hypothermia may be mediated by development of tolerance to the effects of beta-endorphin on brain dopamine and serotonin release. Serotonin 206-215 proopiomelanocortin Homo sapiens 169-183 703527-0 1978 Effects of beta-endorphin on brain serotonin metabolism. Serotonin 35-44 proopiomelanocortin Homo sapiens 11-25 213792-0 1978 Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin. Serotonin 64-73 proopiomelanocortin Homo sapiens 8-12 217195-0 1978 [Inhibition of ACTH hypersecretion in Addison"s disease by serotonin-antagonistic agents]. Serotonin 59-68 proopiomelanocortin Homo sapiens 15-19 168228-9 1975 Caution is recommended, however, before concluding, on the basis of these findings, that serotonin as such plays a physiological stimulating role on ACTH secretion. Serotonin 89-98 proopiomelanocortin Homo sapiens 149-153 190256-8 1977 The adenylate cyclase of two ectopic ACTH producing tumors (gastric carcinoid and malignant thymoma) was activated by TRH, LH-RH, norepinephrine, epinephrine, serotonin, PGE1 and MEE. Serotonin 159-168 proopiomelanocortin Homo sapiens 37-41 181396-9 1976 Taken together, these results lend support to the concept of a physiological stimulating effect of serotonin on ACTH secretion. Serotonin 99-108 proopiomelanocortin Homo sapiens 112-116 177112-2 1975 If this drug acts by antagonizing serotonin, as assumed, this study suggests that serotonin is also involved in L-dopa induced GH and ACTH release. Serotonin 82-91 proopiomelanocortin Homo sapiens 134-138 28099839-0 2017 TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons. Serotonin 32-41 proopiomelanocortin Homo sapiens 54-58 14498637-0 1961 [The effect of ACTH and glucocorticoid administration on the blood serotonin level in man]. Serotonin 67-76 proopiomelanocortin Homo sapiens 15-19 14442959-0 1960 [Studies on the role of 5-hydroxytryptamine in allergic and rheumatic diseases and on the modification of the blood serotonin level by ACTH and glucocorticoids]. Serotonin 116-125 proopiomelanocortin Homo sapiens 135-139 34031163-2 2021 The serotonin 2C receptor (5-HT2CR), a G protein-coupled receptor, activates pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus (ARH) to reduce appetite and weight gain. Serotonin 4-13 proopiomelanocortin Homo sapiens 77-97 34031163-2 2021 The serotonin 2C receptor (5-HT2CR), a G protein-coupled receptor, activates pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of hypothalamus (ARH) to reduce appetite and weight gain. Serotonin 4-13 proopiomelanocortin Homo sapiens 99-103 29678284-3 2018 In addition, paracrine or autocrine production of ligands for the aberrant GPCR such as ACTH or serotonin is found in some adrenal tumors or hyperplasias and participates in a complex regulatory loop causing steroid excess. Serotonin 96-105 proopiomelanocortin Homo sapiens 88-92 28580520-3 2017 The levels of natural antibodies to all antigens were maximum in patients with cardiosclerosis: the content of antibodies to beta-endorphin surpassed the control by 46%, to histamine by 62%, to bradykinin by 36%, to dopamine by 49%, and to serotonin by 65%. Serotonin 240-249 proopiomelanocortin Homo sapiens 125-139 25217810-8 2015 Serotonin interacts within the hypothalamus with endogenous orexigenic (Neuropeptide Y/Agouti related protein) and anorectic (alpha-melanocyte stimulating hormone) peptides. Serotonin 0-9 proopiomelanocortin Homo sapiens 126-162 23756052-2 2013 Pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC), serotonin (5-HT) and its 2C receptor (5-HT2CR) are implicated in anorexia. Serotonin 79-88 proopiomelanocortin Homo sapiens 0-20 23756052-2 2013 Pro-opiomelanocortin (POMC) neurons in the hypothalamic arcuate nucleus (ARC), serotonin (5-HT) and its 2C receptor (5-HT2CR) are implicated in anorexia. Serotonin 79-88 proopiomelanocortin Homo sapiens 22-26 23276607-6 2013 PFC tissue from ACTH pre-treated animals contained significantly higher serotonin, noradrenaline and adrenaline concentrations relative to saline pre-treated controls. Serotonin 72-81 proopiomelanocortin Homo sapiens 16-20 17280595-1 2007 Noradrenaline or serotonin (5-HT) reuptake-inhibiting antidepressants such as reboxetine or citalopram acutely stimulate cortisol and adrenocorticotrophic hormone (ACTH) secretion in healthy volunteers, whereas mirtazapine acutely inhibits the ACTH and cortisol release, probably due to its antagonism at central 5-HT(2) and/or H(1) receptors. Serotonin 17-26 proopiomelanocortin Homo sapiens 164-168 17280595-1 2007 Noradrenaline or serotonin (5-HT) reuptake-inhibiting antidepressants such as reboxetine or citalopram acutely stimulate cortisol and adrenocorticotrophic hormone (ACTH) secretion in healthy volunteers, whereas mirtazapine acutely inhibits the ACTH and cortisol release, probably due to its antagonism at central 5-HT(2) and/or H(1) receptors. Serotonin 17-26 proopiomelanocortin Homo sapiens 244-248