PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Serotonin 8-17 monoamine oxidase B Homo sapiens 268-273 2436247-5 1987 These dose-dependent reductions are consistent with in vitro biochemical and anatomical data from primate brain suggesting that at low doses of deprenyl, MAO-B inhibition might be expected to selectively affect dopamine and serotonin-containing neurons, while at higher doses (which lead to MAO-A as well as MAO-B inhibition), noradrenergic neurons may become relatively more affected by the drug. Serotonin 224-233 monoamine oxidase B Homo sapiens 154-159 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Serotonin 125-134 monoamine oxidase B Homo sapiens 268-273 32942081-1 2020 Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine, serotonin, and some other amines. Serotonin 175-184 monoamine oxidase B Homo sapiens 30-35 27004312-3 2015 CASE REPORT: The authors reported a case of serotonin syndrome associated with combined therapy of monoamine oxidase-B inhibitors and selective serotonin reuptake inhibitor A 77-year-old Thai man had been taking escitalopram for depression for three years. Serotonin 44-53 monoamine oxidase B Homo sapiens 99-118 27605388-0 2016 ONIOM calculations on serotonin degradation by monoamine oxidase B: insight into the oxidation mechanism and covalent reversible inhibition. Serotonin 22-31 monoamine oxidase B Homo sapiens 47-66 27381555-0 2016 Genetic variants of MAOB affect serotonin level and specific behavioral attributes to increase autism spectrum disorder (ASD) susceptibility in males. Serotonin 32-41 monoamine oxidase B Homo sapiens 20-24 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Serotonin 131-140 monoamine oxidase B Homo sapiens 37-56 26593027-1 2012 Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine. Serotonin 182-191 monoamine oxidase B Homo sapiens 71-76 25314256-1 2014 BACKGROUND: The serotonin toxicity syndrome (STS) is a potential risk with concurrent use of the monoamine oxidase type-B inhibitor rasagiline and antidepressants. Serotonin 16-25 monoamine oxidase B Homo sapiens 97-121 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Serotonin 131-140 monoamine oxidase B Homo sapiens 58-63 22365943-4 2012 Patients who lack both MAOA and MAOB have the most extreme laboratory values (urine, blood, and CSF serotonin 4-6 times normal, with elevated O-methylated amine metabolites and reduced deaminated metabolites) in addition to severe intellectual deficiency and behavioral problems. Serotonin 100-109 monoamine oxidase B Homo sapiens 32-36 20642018-6 2004 In the human brain, MAO-B predominates and is present in both glial cells and neurons (6), most abundantly in serotonin and histamine neurons (7). Serotonin 110-119 monoamine oxidase B Homo sapiens 20-25 22035029-10 2011 In patients treated with selective MAO-B inhibitors, the risk of serotonin toxicity (ST) due to a concomitant serotonergic agent (e.g., antidepressants, dextromethorphan, serotonergic analgesics) or hypertensive crisis due to dietary tyramine or sympathomimetic amines appears to be minimal and is based on isolated case reports and overgeneralizations from nonselective MAO inhibitor pharmacology. Serotonin 65-74 monoamine oxidase B Homo sapiens 35-40 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Serotonin 265-274 monoamine oxidase B Homo sapiens 125-144 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Serotonin 265-274 monoamine oxidase B Homo sapiens 146-151 20485326-1 2010 Monoamine oxidases (MAO-A and MAO-B) have a key role in the degradation of amine neurotransmitters, such as dopamine, norepinephrine and serotonin. Serotonin 137-146 monoamine oxidase B Homo sapiens 30-35 19067259-2 2008 Although platelet monoamine oxidase activity (MAO-B) has been proposed as an index of cerebral serotonin activity, studies in patients with AN are scarce. Serotonin 95-104 monoamine oxidase B Homo sapiens 46-51 18774444-7 2008 In this article, the mechanism of action of MAO-B inhibitors, their potential neuroprotective effects, interactions such as the cheese reaction, and serotonin syndrome are discussed. Serotonin 149-158 monoamine oxidase B Homo sapiens 44-49 15959855-3 2006 The aim of the present study was therefore to investigate if platelet MAO-B activity could be related to hormonal and temperature responses to the serotonin active drug DL-fenfluramine in healthy men. Serotonin 147-156 monoamine oxidase B Homo sapiens 70-75 15308297-2 2004 Several studies have suggested that dopamine (DA) uptake into serotonin (5-HT) terminals by the 5-HT reuptake transporter (SERT) and subsequent deamination by monoamine oxidase-B (MAO-B) leads to the formation of hydrogen peroxide and may be major contributors to this serotonergic toxicity. Serotonin 62-71 monoamine oxidase B Homo sapiens 180-185 15717295-2 2005 Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. Serotonin 90-99 monoamine oxidase B Homo sapiens 38-43 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). Serotonin 138-147 monoamine oxidase B Homo sapiens 31-36 12958079-14 2003 This 4.96 Mb region contains, among others, the genes for monoamine oxidase A (MAOA) and B (MAOB), which are involved in the oxidative deamination of several neurotransmitters, including dopamine and serotonin. Serotonin 200-209 monoamine oxidase B Homo sapiens 92-96 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). Serotonin 149-168 monoamine oxidase B Homo sapiens 31-36 11134050-6 2001 The reciprocal mutant MAO B-Y326I exhibited an increased preference for 5-hydroxytryptamine, a decreased preference for beta-phenylethylamine, and, similar to MAO A, was more sensitive to clorgyline than to deprenyl. Serotonin 72-91 monoamine oxidase B Homo sapiens 22-27 8987145-1 1997 Monoamine oxidases A and B (MAOA and MAOB) are the major catabolic isoenzymes of catecholamines and serotonin in the mammalian brain. Serotonin 100-109 monoamine oxidase B Homo sapiens 37-41 10936214-3 2000 When compared with MAO A, MAO A-F208I showed a sixfold decrease in the specificity constant k(cat)/K(m) for both the MAO A- and the MAO B-preferring substrates 5-hydroxytryptamine and beta-phenylethylamine, respectively. Serotonin 160-179 monoamine oxidase B Homo sapiens 132-137 9406907-2 1997 Our results showed that the 5-hydroxytryptamine (5-HT) content in platelets was: (1) increased in the subgroup of anti-social alcoholics; (2) transiently and differently altered in alcoholics compared to opiate addicts; and (3) lowered in drinking alcoholics and normal in alcoholics who were drinking as well as smoking (that may occur via MAO-B inhibition by smoke). Serotonin 28-47 monoamine oxidase B Homo sapiens 341-346 8678123-1 1996 The monoamine oxidases (MAO-A and MAO-B) are the enzymes primarily responsible for the degradation of amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. Serotonin 165-174 monoamine oxidase B Homo sapiens 34-39 1759390-6 1991 After selective inhibition of MAO-A by chlorgyline the order of MAO-B-dependent effects of biogenic amines on mitochondrial enzymes studied was as follows: tyramine greater than or equal to 2-phenylethylamine much greater than serotonin. Serotonin 227-236 monoamine oxidase B Homo sapiens 64-69 8573115-3 1996 Moreover the enzymatic activity of MAO-B towards phenylethylamine and tyramine is also suppressed after this immunoprecipitation, contrary to the MAO-A activity towards 5-hydroxy-tryptamine. Serotonin 169-189 monoamine oxidase B Homo sapiens 35-40 7995014-2 1994 Although not all features of its antiParkinson action are known, studies that used brains obtained at autopsy from patients who took l-deprenyl show that the selective inhibition of MAO-B with a concomitant increase of phenylethylamine and dopamine, but not of serotonin or noradrenaline, in the basal ganglia may be responsible for its mode of action. Serotonin 261-270 monoamine oxidase B Homo sapiens 182-187 8242348-2 1993 Activities of both MAOA and MAOB were significantly increased in frontal cortex and caudate nucleus, two brain regions shown previously to be the site of functional and morphological alterations of astrocytes and increased concentrations of the acid metabolites of dopamine and serotonin. Serotonin 278-287 monoamine oxidase B Homo sapiens 28-32 1741773-8 1991 The ratio, MAO A molecular activity:MAO B molecular activity decreased in the order: serotonin (35:1) greater than tryptamine (12:1) greater than tyramine (3.3:1) greater than dopamine (2.4:1) greater than benzylamine (1:23). Serotonin 85-94 monoamine oxidase B Homo sapiens 36-41 2222781-3 1990 In view of the part that MAO B plays in metabolizing serotonin (5HT) and of the relationship which exists between 3H-IMI binding and 5HT uptake, our results would suggest that with AD there occurs a complex dysfunction in the 5HT system, at least at a peripheral level. Serotonin 53-62 monoamine oxidase B Homo sapiens 25-30 2222781-3 1990 In view of the part that MAO B plays in metabolizing serotonin (5HT) and of the relationship which exists between 3H-IMI binding and 5HT uptake, our results would suggest that with AD there occurs a complex dysfunction in the 5HT system, at least at a peripheral level. Serotonin 64-67 monoamine oxidase B Homo sapiens 25-30 2622533-3 1989 While dopaminergic neurons of the substantia nigra revealed no staining for monoamine oxidase, noradrenergic neurons of the locus coeruleus stained positively with the monoamine oxidase-A substrate serotonin, and serotonergic neurons of the raphe nuclei were stained by the monoamine oxidase-B substrate beta-phenylethylamine. Serotonin 198-207 monoamine oxidase B Homo sapiens 274-293 3399053-6 1988 The major accumulation of monoamine oxidase B-positive neurons was observed in the same regions in which monoamine oxidase B is found to co-localize with serotonin in monkey tissues, including the nucleus raphe dorsalis and the nucleus centralis superior. Serotonin 154-163 monoamine oxidase B Homo sapiens 26-45 3399053-6 1988 The major accumulation of monoamine oxidase B-positive neurons was observed in the same regions in which monoamine oxidase B is found to co-localize with serotonin in monkey tissues, including the nucleus raphe dorsalis and the nucleus centralis superior. Serotonin 154-163 monoamine oxidase B Homo sapiens 105-124