PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31172579-0	2019	Stimulating DDX3 expression by serotonin 5-HT receptor 7 through phosphorylation of p53 via the AC-PKA-ERK signaling pathway.	Serotonin	31-40	DEAD-box helicase 3 X-linked	Homo sapiens	12-16	
31172579-2	2019	In this study, the 20 bioactive compounds have screened the effects on DDX3 and we found that 5-HT upregulated DDX3 promoter activity via the 5-HT7 receptor on liver hepatocellular cells (HepG2 cells) by using a luciferase assay, reverse transcription-polymerase chain reaction analysis, and Western blot analysis.	Serotonin	94-98	DEAD-box helicase 3 X-linked	Homo sapiens	71-75	
31172579-2	2019	In this study, the 20 bioactive compounds have screened the effects on DDX3 and we found that 5-HT upregulated DDX3 promoter activity via the 5-HT7 receptor on liver hepatocellular cells (HepG2 cells) by using a luciferase assay, reverse transcription-polymerase chain reaction analysis, and Western blot analysis.	Serotonin	94-98	DEAD-box helicase 3 X-linked	Homo sapiens	111-115	
31172579-3	2019	Furthermore, we are trying to elucidate the pathways involved in the stimulating effect of 5-HT on DDX3 expression to induce innate immune responses against hepatitis B virus infection.	Serotonin	91-95	DEAD-box helicase 3 X-linked	Homo sapiens	99-103	
31172579-4	2019	A knockdown of the 5-HT7 receptor by transfection si-5-HT7 receptors or si-control into HepG2 cells treated by 5-HT (or 5-HT plus agonist) confirmed the role of the 5-HT7 receptor in DDX3 expression.	Serotonin	19-23	DEAD-box helicase 3 X-linked	Homo sapiens	183-187