PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29523808-4 2018 Using TALEN-mediated gene targeting, we show that in human B cells Grb2 and GRAP amplify signaling by the immunoglobulin tail tyrosine (ITT) motif of mIgE-containing BCRs and furthermore connect immunoreceptor tyrosine-based activation motif (ITAM) signaling to activation of the Ras-controlled Erk MAP kinase pathway. Inosine Triphosphate 136-139 growth factor receptor bound protein 2 Homo sapiens 67-71