PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16139176-2	2005	Recent studies show that several behavioural effects of the psychotomimetic drug, phencyclidine (PCP), in rodents are blocked by nitric oxide synthase (NOS) inhibitors suggesting that NO plays an important role in the pharmacological effects of PCP.	Phencyclidine	82-95	nitric oxide synthase 1, neuronal	Mus musculus	129-150	
15496304-0	2004	The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice.	Phencyclidine	104-117	nitric oxide synthase 1, neuronal	Mus musculus	23-44	
15496304-2	2004	In the present study, the ability of the neuronal selective nitric oxide synthase (NOS) inhibitor, Nomega-propyl-L-arginine, to block the behavioural effects of phencyclidine in mice was investigated.	Phencyclidine	161-174	nitric oxide synthase 1, neuronal	Mus musculus	60-81	
11432693-3	2001	OBJECTIVE AND METHODS: The primary objective was to determine whether neuronal NO synthase (nNOS) is involved in PCP-induced behaviours and neuronal activation, as measured by the expression of c-Fos.	Phencyclidine	113-116	nitric oxide synthase 1, neuronal	Mus musculus	92-96	
14748849-4	2004	This effect is blocked by nitric oxide synthase (NOS) inhibitors, suggesting that nitric oxide plays an important role in this effect of phencyclidine.	Phencyclidine	137-150	nitric oxide synthase 1, neuronal	Mus musculus	26-47	
14748849-11	2004	The results from the present study further support the suggestion that the nitric oxide synthase/guanylate cyclase pathway is involved in pharmacological and behavioural effects of phencyclidine.	Phencyclidine	181-194	nitric oxide synthase 1, neuronal	Mus musculus	75-96	
14748849-12	2004	Since phencyclidine as well exerts psychotomimetic characteristics, agents that interfere with the nitric oxide synthase/guanylate cyclase pathway may be of therapeutic value also in the treatment of schizophrenia.	Phencyclidine	6-19	nitric oxide synthase 1, neuronal	Mus musculus	99-120	
11549221-0	2001	The nitric oxide synthase inhibitor, L-NAME, block phencyclidine-induced disruption of prepulse inhibition in mice.	Phencyclidine	51-64	nitric oxide synthase 1, neuronal	Mus musculus	4-25	
11549221-3	2001	Recent studies show that the behavioural and biochemical effects of PCP in rats are blocked by nitric oxide synthase (NOS) inhibitors, suggesting that NO plays an important role in the pharmacological effects of PCP.	Phencyclidine	68-71	nitric oxide synthase 1, neuronal	Mus musculus	95-116	
11549221-3	2001	Recent studies show that the behavioural and biochemical effects of PCP in rats are blocked by nitric oxide synthase (NOS) inhibitors, suggesting that NO plays an important role in the pharmacological effects of PCP.	Phencyclidine	212-215	nitric oxide synthase 1, neuronal	Mus musculus	95-116	
11312647-7	2001	Inhibitors of inducible nitric oxide synthase (NOS) abrogated PCP-potentiated CMH, although repetitive PCP treatment alone did not increase nitric oxide synthesis systemically or locally in hepatic tissue nor did lipopolysaccharide induction of NOS (without PCP) directly potentiate CMH.	Phencyclidine	62-65	nitric oxide synthase 1, neuronal	Mus musculus	24-45	
11432693-4	2001	After characterizing a PCP mouse model (dose-response study, Experiment 1), we measured PCP-induced effects in mice treated with nNOS antisense oligodeoxynucleotides (AS-ODNs) (Experiment 2), and in nNOS knockout (nNOS-/-) mice (Experiment 3).	Phencyclidine	88-91	nitric oxide synthase 1, neuronal	Mus musculus	129-133	
11432693-8	2001	In the nNOS-/- mice, PCP induced less behaviour and a decrease in Fos-LIR in the frontal cortex and midline limbic areas, when compared to wild-type littermate controls.	Phencyclidine	21-24	nitric oxide synthase 1, neuronal	Mus musculus	7-11	
11432693-10	2001	Furthermore, we show that an intact nNOS system is necessary to obtain PCP-induced effects.	Phencyclidine	71-74	nitric oxide synthase 1, neuronal	Mus musculus	36-40	
9608580-0	1998	Nitric oxide synthase inhibitors attenuate phencyclidine-induced disruption of prepulse inhibition.	Phencyclidine	43-56	nitric oxide synthase 1, neuronal	Mus musculus	0-21	
11080550-2	2000	PCP-induced place aversion in naive mice was dose-dependently attenuated by administration of N(G)-nitro-L-arginine methyl ester (L-NAME), a NO synthase (NOS) inhibitor, during the conditioning.	Phencyclidine	0-3	nitric oxide synthase 1, neuronal	Mus musculus	141-152