PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3018693-2 1986 Sweat secretion may also be regulated by Vasoactive Intestinal Peptide (VIP), which coexists with acetylcholine in nerves to sweat gland acini and ducts. Acetylcholine 98-111 vasoactive intestinal peptide Homo sapiens 41-70 2699832-5 1989 However in the ileum a portion of the vesicle-bound acetylcholine is recovered in the VIP-storing particles and this might indicate a precursor-product relationship for the two types of vesicle in this system analogous to that which has been proposed for electron-dense and electron-translucent vesicles in noradrenergic nerves. Acetylcholine 52-65 vasoactive intestinal peptide Homo sapiens 86-89 2834698-7 1988 Acetylcholine at 50 microM and high potassium stimulated fetal adrenal VIP release while norepinephrine did not. Acetylcholine 0-13 vasoactive intestinal peptide Homo sapiens 71-74 3035984-7 1987 The synthesis and secretion of VIP is also coupled to acetylcholine and elevated potassium stimulation by calcium influx. Acetylcholine 54-67 vasoactive intestinal peptide Homo sapiens 31-34 2867688-2 1986 The modulation of cortical VIP release by several neurotransmitters [gamma-aminobutyric acid (GABA), opioids, norepinephrine, acetylcholine, and glutamate] normally present in the cerebral cortex was studied by administering respective agonists and antagonists for their receptors. Acetylcholine 126-139 vasoactive intestinal peptide Homo sapiens 27-30 2699758-3 1989 Vasoactive intestinal polypeptide (VIP) and peptide with N- and C-terminal histidine (PHI) are released together with acetylcholine from parasympathetic nerves. Acetylcholine 118-131 vasoactive intestinal peptide Homo sapiens 0-33 2699758-3 1989 Vasoactive intestinal polypeptide (VIP) and peptide with N- and C-terminal histidine (PHI) are released together with acetylcholine from parasympathetic nerves. Acetylcholine 118-131 vasoactive intestinal peptide Homo sapiens 35-38 3567070-5 1987 VIP and acetylcholine in human sweat glands most probably act through a receptor complex, where adenylate cyclase is coupled to that part of the receptor stimulated by VIP. Acetylcholine 8-21 vasoactive intestinal peptide Homo sapiens 168-171 2455195-4 1987 Examples include the interactions of neuropeptide Y (NPY) with noradrenaline (NA) and adenosine 5"-triphosphate (ATP) released from some sympathetic nerves; vasoactive intestinal polypeptide (VIP) with acetylcholine (ACh) released from some parasympathetic nerves; and NPY and 5-hydroxytryptamine (5-HT) released from intracardiac neurones supplying coronary vessels. Acetylcholine 202-215 vasoactive intestinal peptide Homo sapiens 157-190 3018693-2 1986 Sweat secretion may also be regulated by Vasoactive Intestinal Peptide (VIP), which coexists with acetylcholine in nerves to sweat gland acini and ducts. Acetylcholine 98-111 vasoactive intestinal peptide Homo sapiens 72-75 6400363-2 1984 They can serve as cotransmitters in the autonomic nervous system; for example, vasoactive intestinal peptide (VIP) is released with acetylcholine and neuropeptide Y with norepinephrine from postganglionic neurons. Acetylcholine 132-145 vasoactive intestinal peptide Homo sapiens 110-113 34055794-9 2021 In contrast, the ACh-alpha7nAChR axis in ILC2 diminishes the synthesis of TNF-alpha, IL-1, and IL-6, attenuating lung inflammation whereas, VIP-VPAC1, N/OFQ-NOP axes cause bronchodilation and anti-inflammatory effects. Acetylcholine 17-20 vasoactive intestinal peptide Homo sapiens 140-143 6084454-4 1984 Thus, it has been shown that VIP coreleased with acetylcholine from the same parasympathetic fibres can facilitate the interaction of this neurotransmitter with muscarinic receptors on target cells. Acetylcholine 49-62 vasoactive intestinal peptide Homo sapiens 29-32 7345898-13 1981 Since VIP may be present in cholinergic neurons, data from the literature concerning acetylcholine release are discussed in relation to the observed VIP output. Acetylcholine 85-98 vasoactive intestinal peptide Homo sapiens 6-9 28525692-5 2016 Acetylcholine-containing sympathetic neurons in most cases colocalize VIP and/or CGRP. Acetylcholine 0-13 vasoactive intestinal peptide Homo sapiens 70-73 33301603-5 2021 The genetic profile of these VIP+ /ChAT+ interneurons suggests that they can release both gamma-aminobutyric acid (GABA) and acetylcholine (ACh). Acetylcholine 125-138 vasoactive intestinal peptide Homo sapiens 29-32 33301603-5 2021 The genetic profile of these VIP+ /ChAT+ interneurons suggests that they can release both gamma-aminobutyric acid (GABA) and acetylcholine (ACh). Acetylcholine 140-143 vasoactive intestinal peptide Homo sapiens 29-32 25509256-12 2014 (3) Compared with the.control group, plasma 5-HT levels significantly increased, plasma VIP and IL-10 levels significantly decreased in ach subtype of D-IBS complicated FD patients of GSPDS (P <0.05, P <0.01), and no significant change of SS, ET, or IL-12 occurred (P >0.05). Acetylcholine 136-139 vasoactive intestinal peptide Homo sapiens 88-91 24108336-4 2013 Several purines and peptides have been postulated as neurotransmitters of this system, and some of them coexist with the acetylcholine or norepinephrine; for example, vasoactive intestinal peptide (VIP) on cholinergic nerves and neuropeptide Y in the adrenergic nerves. Acetylcholine 121-134 vasoactive intestinal peptide Homo sapiens 167-196 8782112-17 1996 The potentiation of nicotinic ACh-evoked currents by VIP is likely to account for the altered neuronal activity observed in the mammalian intracardiac ganglia in vivo and consequent changes in heart rate and cardiac contractility. Acetylcholine 30-33 vasoactive intestinal peptide Homo sapiens 53-56 16931551-4 2006 We investigated the effects of different concentrations of calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP) and substance P (SP) on acetylcholine-induced axon reflex sweating in healthy subjects (total n = 18). Acetylcholine 159-172 vasoactive intestinal peptide Homo sapiens 130-133 16004938-13 2005 While evidence associating these conditions is thin, vasoactive neuropeptide neurotransmitters of the VIP/PACAP family have acetylcholine co-transmission functions via specific GPCRs. Acetylcholine 124-137 vasoactive intestinal peptide Homo sapiens 102-105 10644885-3 2000 This finding has led to the discovery that nitric oxide (NO), which is coreleased with ACh and neural peptides such as vasoactive intestinal polypeptide (VIP) from the respective cholinergic-nitrergic (nitric oxidergic) nerves and the VIPergic-nitrergic nerves, is the primary transmitter in relaxing smooth muscle. Acetylcholine 87-90 vasoactive intestinal peptide Homo sapiens 154-157 9134222-8 1997 PACAP and VIP were both more potent that acetylcholine (ACh). Acetylcholine 56-59 vasoactive intestinal peptide Homo sapiens 10-13 17525359-8 2007 Thus, in the human submandibular artery, ACh and VIP produced endothelium-dependent vasodilation with different underlying mechanisms: release of nitric oxide (NO) and cyclo-oxygenase products for ACh, and release of NO and endothelium-derived hyperpolarizing factor for VIP. Acetylcholine 41-44 vasoactive intestinal peptide Homo sapiens 271-274 17525359-8 2007 Thus, in the human submandibular artery, ACh and VIP produced endothelium-dependent vasodilation with different underlying mechanisms: release of nitric oxide (NO) and cyclo-oxygenase products for ACh, and release of NO and endothelium-derived hyperpolarizing factor for VIP. Acetylcholine 197-200 vasoactive intestinal peptide Homo sapiens 49-52 17408637-5 2007 RESULTS: The incubation of human colonic circular smooth muscle cells or muscle strips with VIP for 24 hours enhanced the expression of alpha(1C) protein and mRNA as well as the contractile response to acetylcholine and KCl. Acetylcholine 202-215 vasoactive intestinal peptide Homo sapiens 92-95 1663178-1 1991 It has been reported that low concentrations of vasoactive intestinal peptide (VIP) suppress the release of acetylcholine (ACh) from vagal nerve terminals. Acetylcholine 108-121 vasoactive intestinal peptide Homo sapiens 79-82 7477763-6 1995 The simultaneous addition of ACh with CGRP potentiated the relaxation induced by CGRP, as has already been shown for substance P. ACh did not potentiate VIP relaxation, but the results generally indicate a potential role for ACh in initiating rapid dilation prior to strong, sustained relaxation by CGRP or VIP. Acetylcholine 29-32 vasoactive intestinal peptide Homo sapiens 307-310 7623776-6 1995 The increased ACh sensitivity induced by 10 nM PACAP38 or PACAP27 or 1 microM VIP depends on coincident increases in cAMP levels, because treatment of neurons with adenylate cyclase inhibitors blocked both effects. Acetylcholine 14-17 vasoactive intestinal peptide Homo sapiens 78-81 8201830-8 1994 This study suggests that endogenous VIP may suppresses ACh release from the vagus nerve terminals in the human airway. Acetylcholine 55-58 vasoactive intestinal peptide Homo sapiens 36-39 1664942-3 1991 A high VIP concentration (100 nM) acutely and reversibly inhibited the responses evoked by 1 nM VIP and also acutely inhibited ACh-evoked responses. Acetylcholine 127-130 vasoactive intestinal peptide Homo sapiens 7-10 7623776-2 1995 Vasoactive intestinal peptide (VIP) can act as a first messenger in the regulation, because application of 1 microM VIP rapidly increases both neuronal cAMP levels and ACh sensitivity. Acetylcholine 168-171 vasoactive intestinal peptide Homo sapiens 31-34 7623776-2 1995 Vasoactive intestinal peptide (VIP) can act as a first messenger in the regulation, because application of 1 microM VIP rapidly increases both neuronal cAMP levels and ACh sensitivity. Acetylcholine 168-171 vasoactive intestinal peptide Homo sapiens 116-119 8389825-12 1993 The effects of VIP bore a remarkable resemblance to those reported previously for the muscarinic action of acetylcholine (ACh). Acetylcholine 107-120 vasoactive intestinal peptide Homo sapiens 15-18 8389825-12 1993 The effects of VIP bore a remarkable resemblance to those reported previously for the muscarinic action of acetylcholine (ACh). Acetylcholine 122-125 vasoactive intestinal peptide Homo sapiens 15-18 8389825-17 1993 That is to say, cells that were facilitated by VIP were facilitated also by ACh or MeCh, and vice versa. Acetylcholine 76-79 vasoactive intestinal peptide Homo sapiens 47-50 1663178-1 1991 It has been reported that low concentrations of vasoactive intestinal peptide (VIP) suppress the release of acetylcholine (ACh) from vagal nerve terminals. Acetylcholine 123-126 vasoactive intestinal peptide Homo sapiens 79-82 1706332-4 1990 284: 515-521, 180) hypothesized that it is vasoactive intestinal polypeptide (VIP) that is cotransmitted with acetylcholine. Acetylcholine 110-123 vasoactive intestinal peptide Homo sapiens 43-76 1706332-4 1990 284: 515-521, 180) hypothesized that it is vasoactive intestinal polypeptide (VIP) that is cotransmitted with acetylcholine. Acetylcholine 110-123 vasoactive intestinal peptide Homo sapiens 78-81 2203825-1 1990 Vasoactive intestinal peptide (VIP), which is present with acetylcholine in parasympathetic nerve fibers, may have important regulatory functions in mucous membranes. Acetylcholine 59-72 vasoactive intestinal peptide Homo sapiens 0-29 2203825-1 1990 Vasoactive intestinal peptide (VIP), which is present with acetylcholine in parasympathetic nerve fibers, may have important regulatory functions in mucous membranes. Acetylcholine 59-72 vasoactive intestinal peptide Homo sapiens 31-34 2267295-9 1990 In salivary glands VIP has been shown to potentiate the salivatory volume response to ACh. Acetylcholine 86-89 vasoactive intestinal peptide Homo sapiens 19-22