PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2455787-11 1988 To examine the ability of methionine enkephalin to alter acetylcholine release from pancreatic tissue, pancreatic lobules were incubated with [3H]choline and the release of synthesized [3H]acetylcholine was stimulated by KCl. Acetylcholine 57-70 proenkephalin Rattus norvegicus 37-47 2752969-9 1989 Intra-adrenal application of Met-Enk reduced Ach-stimulated epinephrine, but not norepinephrine, secretion significantly; application of Nal did not affect Ach-stimulated catecholamine secretion in the initial fraction after Ach injection, but significantly prolonged amine secretion after the cholinergic stimulus. Acetylcholine 45-48 proenkephalin Rattus norvegicus 33-36 2752969-11 1989 Thus, naloxone prevented the inhibitory effect of Met-Enk on Ach-stimulated CA release. Acetylcholine 61-64 proenkephalin Rattus norvegicus 54-57 2752969-13 1989 We demonstrate in vivo a paracrine or autocrine action of Met-Enk on Ach-stimulated catecholamine release by applying the peptide directly into the adrenal gland via a microdialysis system. Acetylcholine 69-72 proenkephalin Rattus norvegicus 62-65 2852536-3 1988 In the absence of a cholinesterase inhibitor, 1 microM D-Pen2,L-Pen5-enkephalin produced a 46 and 35% decrease in the release of [3H]ACh evoked by 15 and 25 mM K+, respectively. Acetylcholine 133-136 proenkephalin Rattus norvegicus 69-79 2852536-4 1988 The depressant action of the enkephalin analogue was concentration dependent, with a maximal effect on K+-evoked [3H]ACh release occurring at 1.0 microM, and was completely blocked in the presence of the delta-opioid receptor selective antagonist, ICI 174864 (1 microM). Acetylcholine 117-120 proenkephalin Rattus norvegicus 29-39 2990945-1 1985 In rabbit isolated atria, [D-Ala2,Met5]enkephalinamide and [D-Ala2,D-Leu5]enkephalin (0.1-3 microM) inhibited responses to cholinergic nerve stimulation in a concentration-dependent manner without affecting responses to exogenous acetylcholine. Acetylcholine 230-243 proenkephalin Rattus norvegicus 39-49 2413943-5 1985 The highest frequency was observed at 27-28 degrees C. Dopamine, 5-hydroxytryptamine, histamine, acetylcholine, glutamic acid, substance P, and thyrotropin releasing hormone accelerated the respiratory frequency when applied by perfusion to the brainstem, whereas noradrenaline, gamma-aminobutyric acid, glycine, and [Met5] enkephalin and [Leu5] enkephalin slowed the frequency. Acetylcholine 97-110 proenkephalin Rattus norvegicus 324-334 2413943-5 1985 The highest frequency was observed at 27-28 degrees C. Dopamine, 5-hydroxytryptamine, histamine, acetylcholine, glutamic acid, substance P, and thyrotropin releasing hormone accelerated the respiratory frequency when applied by perfusion to the brainstem, whereas noradrenaline, gamma-aminobutyric acid, glycine, and [Met5] enkephalin and [Leu5] enkephalin slowed the frequency. Acetylcholine 97-110 proenkephalin Rattus norvegicus 346-356 2990945-5 1985 In rat isolated atria, [D-Ala2,Met5]enkephalinamide and [D-Ala2,D-Leu5]enkephalin (0.3-3 microM) inhibited responses to cholinergic nerve stimulation without affecting responses to exogenous acetylcholine. Acetylcholine 191-204 proenkephalin Rattus norvegicus 36-46 6571228-0 1983 Antagonism of enkephalin action on acetylcholine release by methylxanthines: lack of a purine link. Acetylcholine 35-48 proenkephalin Rattus norvegicus 14-24 3937614-0 1985 [Investigations on the relationship between methionine-enkephalin (Met-Enk) and acetylcholine (ACh) in brain of rats, with their influence on the effect of electroacupuncture analgesia]. Acetylcholine 80-93 proenkephalin Rattus norvegicus 71-74 3937614-0 1985 [Investigations on the relationship between methionine-enkephalin (Met-Enk) and acetylcholine (ACh) in brain of rats, with their influence on the effect of electroacupuncture analgesia]. Acetylcholine 95-98 proenkephalin Rattus norvegicus 71-74 6148016-4 1984 A nervous mechanism involving acetylcholine was further suggested by the inhibitory action of methionine-enkephalin on gastrin release after vagal section. Acetylcholine 30-43 proenkephalin Rattus norvegicus 105-115 6571228-4 1983 and a systemically active enkephalin FK 33,824 (0.5 mg kg-1) on the release of acetylcholine (ACh) from the rat cortex in vivo. Acetylcholine 79-92 proenkephalin Rattus norvegicus 26-36 6571228-4 1983 and a systemically active enkephalin FK 33,824 (0.5 mg kg-1) on the release of acetylcholine (ACh) from the rat cortex in vivo. Acetylcholine 94-97 proenkephalin Rattus norvegicus 26-36 6141249-0 1983 [D-Ala2,D-Met5NH2]-enkephalin inhibits acetylcholine release from the submucosal plexus of rat colon. Acetylcholine 39-52 proenkephalin Rattus norvegicus 19-29 7178189-6 1982 Iontophoretic or SC naloxone usually antagonized the excitatory actions of ethanol, salsolinol and methionine5-enkephalin on HPC pyramidal cells; however, ACh-induced speeding also was antagonized occasionally. Acetylcholine 155-158 proenkephalin Rattus norvegicus 111-121 6871966-4 1983 These observations suggest that splanchnic nerve activity normally depresses the levels of enkephalin-like peptides in chromaffin cells through a trans-synaptic mechanism involving acetylcholine release and nicotinic receptor stimulation. Acetylcholine 181-194 proenkephalin Rattus norvegicus 91-101 209425-0 1978 Increase by enkephalin of acetylcholine release from striatal slices of the rat. Acetylcholine 26-39 proenkephalin Rattus norvegicus 12-22 6106904-0 1980 Actions of enkephalin, mu and partial agonist analgesics on acetylcholine turnover in rat brain. Acetylcholine 60-73 proenkephalin Rattus norvegicus 11-21 7470737-0 1980 Investigation of action of enkephalin on the spontaneous and evoked release of acetylcholine from rat cortical and striatal slices. Acetylcholine 79-92 proenkephalin Rattus norvegicus 27-37 6191322-5 1981 It is suggested that methionine enkephalin and/or beta-endorphin and Substance P regulate release of acetylcholine or hormones from placental villus. Acetylcholine 101-114 proenkephalin Rattus norvegicus 32-42 17949415-4 2007 In the afternoon, the NK(1)R antagonist response required the suppression of the enkephalin/MOR inhibitory control of acetylcholine release by betafunaltrexamine. Acetylcholine 118-131 proenkephalin Rattus norvegicus 81-91 909611-2 1977 In rat brain slices preincubated with various radiolabelled putative neurotransmitters, methionine-enkephalin diminished the potassium-evoked release of dopamine and acetylcholine. Acetylcholine 166-179 proenkephalin Rattus norvegicus 99-109 16367789-5 2005 These data suggest a novel role for striatal acetylcholine in modulating feeding behavior via its effects on enkephalin gene expression. Acetylcholine 45-58 proenkephalin Rattus norvegicus 109-119 17425581-2 2007 In the limbic-prefrontal territory of the dorsal striatum, enkephalin inhibits the NMDA-evoked release of acetylcholine directly through micro-opioid receptors (MORs) located on cholinergic interneurons and indirectly through MORs of output neurons of striosomes. Acetylcholine 106-119 proenkephalin Rattus norvegicus 59-69 17425581-5 2007 Accordingly, the direct enkephalin-MOR control of acetylcholine release was preserved after 6-hydroxydopamine treatment and lost after cocaine exposure. Acetylcholine 50-63 proenkephalin Rattus norvegicus 24-34 17425581-7 2007 Accordingly, the indirect enkephalin-MOR control of acetylcholine release disappeared in the 6-hydroxydopamine situation but surprisingly, despite preservation of MORs in striosomes, disappeared after cocaine treatment. Acetylcholine 52-65 proenkephalin Rattus norvegicus 26-36 17425581-8 2007 Showing that MORs of striosomes are still functional in this situation, the MOR agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin inhibited the NMDA-evoked release of acetylcholine after cocaine exposure. Acetylcholine 169-182 proenkephalin Rattus norvegicus 121-131 8013552-3 1994 The potassium (K+)-evoked acetylcholine release from the splanchnic nerve terminals was inhibited by morphine (10 microM), a mu-opioid receptor agonist, and [D-Pen2,D-Pen5]enkephalin (DPDPE, 1 and 10 microM), a delta-opioid receptor agonist. Acetylcholine 26-39 proenkephalin Rattus norvegicus 172-182 14706785-2 2004 The role of micro-opioid receptors, activated by endogenously released enkephalin, on the NMDA-evoked release of ACh was studied using the selective micro-opioid receptor antagonist, beta-funaltrexamine. Acetylcholine 113-116 proenkephalin Rattus norvegicus 71-81 10323308-2 1999 Of 17 compounds tested, acetylcholine (Ach), neuropeptide Y (NPY), norepinephrine (NE), and met-enkephalin (met-Enk) were effective modulators of the Ca2+ currents. Acetylcholine 24-37 proenkephalin Rattus norvegicus 112-115 16026468-10 2005 Therefore, by acting on MORs present on cholinergic interneurons, endogenously released enkephalin reduces ACh release. Acetylcholine 107-110 proenkephalin Rattus norvegicus 88-98 7498306-3 1995 Following chronic morphine treatment this adaptive increase of acetylcholine release was associated with a slight but long-lasting decrease of the (delta-opioid receptor-mediated) maximal inhibitory effect of [Met5]enkephalin, whereas upon intermittent drug treatment delta-opioid receptor desensitization was observed 1 day after opiate withdrawal only. Acetylcholine 63-76 proenkephalin Rattus norvegicus 215-225 1933369-1 1991 Endogenous acetylcholine (ACh) release from rat neostriatal slices was inhibited by the mu-opioid agonist [D-Ala2,Gly(ol)5]-enkephalin (DAGO) both in 6-hydroxydopamine (6-OHDA)-lesioned and non-lesioned neostriatum. Acetylcholine 11-24 proenkephalin Rattus norvegicus 124-134 1933369-1 1991 Endogenous acetylcholine (ACh) release from rat neostriatal slices was inhibited by the mu-opioid agonist [D-Ala2,Gly(ol)5]-enkephalin (DAGO) both in 6-hydroxydopamine (6-OHDA)-lesioned and non-lesioned neostriatum. Acetylcholine 26-29 proenkephalin Rattus norvegicus 124-134 1683474-4 1991 Furthermore, [D-Ala2, D-Leu5]enkephalin inhibition of glutamate-evoked acetylcholine release was prevented by D2 antagonists in a concentration-dependent manner. Acetylcholine 71-84 proenkephalin Rattus norvegicus 29-39 1683474-5 1991 Instead, in the 6-hydroxydopamine-lesioned side, while [D-Ala2, D-Leu5]enkephalin (1 microM) inhibition of glutamate-evoked acetylcholine release was completely abolished, morphine (1 microM) inhibition remained unchanged. Acetylcholine 124-137 proenkephalin Rattus norvegicus 71-81 2158852-4 1990 The delta-receptor selective opioid peptide [D-Pen2, D-Pen5]enkephalin (0.3 micromol/l) inhibited [3H]acetylcholine release in all groups, although its effect was smaller in grafts than in normal tissue. Acetylcholine 98-115 proenkephalin Rattus norvegicus 60-70 2158852-5 1990 The preferential mu-receptor agonist [D-Ala2,N-methyl-Phe4,Gly-ol5]enkephalin also reduced [3H]acetylcholine release in all groups, but only at the high concentration of 10 micromols/l. Acetylcholine 95-108 proenkephalin Rattus norvegicus 67-77 2166675-5 1990 [14C]ACh release from both the nucleus accumbens and olfactory tubercle, but not from the frontal cortex, was inhibited by DAGO (0.01-1 microM) and the delta agonist, [D-Pen2,D-Pen5]enkephalin (DPDPE, 0.01-1 microM). Acetylcholine 5-8 proenkephalin Rattus norvegicus 182-192