PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29874875-3 2018 CMS due to mutations in SLC5A7 and SLC18A3, impairing the synthesis and recycling of acetylcholine, have recently been described. Acetylcholine 85-98 solute carrier family 18 member A3 Homo sapiens 35-42 33548369-2 2021 The storage and release of ACh depends on the activity of the Vesicular Acetylcholine Transporter (VAChT), a rate-limiting step for cholinergic neurotransmission whose loss of function mutations was shown to cause human congenital myasthenia. Acetylcholine 27-30 solute carrier family 18 member A3 Homo sapiens 62-97 33548369-2 2021 The storage and release of ACh depends on the activity of the Vesicular Acetylcholine Transporter (VAChT), a rate-limiting step for cholinergic neurotransmission whose loss of function mutations was shown to cause human congenital myasthenia. Acetylcholine 27-30 solute carrier family 18 member A3 Homo sapiens 99-104 31059209-4 2019 Our investigations revealed a homozygous nonsense variant [c.1116C>A, p.(Cys372Ter)] in the SLC18A3 gene, which encodes for the vesicular acetylcholine transporter (VAChT) responsible for active transport of acetylcholine in the neuromuscular junction. Acetylcholine 138-151 solute carrier family 18 member A3 Homo sapiens 92-99 31059209-4 2019 Our investigations revealed a homozygous nonsense variant [c.1116C>A, p.(Cys372Ter)] in the SLC18A3 gene, which encodes for the vesicular acetylcholine transporter (VAChT) responsible for active transport of acetylcholine in the neuromuscular junction. Acetylcholine 138-151 solute carrier family 18 member A3 Homo sapiens 165-170 28421605-5 2017 In particular, we focus on how the transporters for ACh (VAChT) and Glu (VGLUT3) influence the storage of neurotransmitters in CINs. Acetylcholine 52-55 solute carrier family 18 member A3 Homo sapiens 57-62 27590285-9 2016 CONCLUSIONS: VAChT is responsible for uptake of acetylcholine into presynaptic vesicles. Acetylcholine 48-61 solute carrier family 18 member A3 Homo sapiens 13-18 28058727-0 2017 ExPPNing how acetylcholine improves gait in Parkinson"s disease: An Editorial Highlight for "Deletion of the Vesicular Acetylcholine Transporter from Pedunculopontine/laterodorsal tegmental neurons modifies gait". Acetylcholine 13-26 solute carrier family 18 member A3 Homo sapiens 109-144 26541750-3 2015 In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is responsible for the uptake of monoamines, vesicular acetylcholine transporter (VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate. Acetylcholine 128-141 solute carrier family 18 member A3 Homo sapiens 155-160 26813123-2 2016 The enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl-CoA and choline in the cytoplasm and the vesicular acetylcholine transporter (VAChT) uptakes the neurotransmitter into synaptic vesicles. Acetylcholine 76-79 solute carrier family 18 member A3 Homo sapiens 133-168 26813123-2 2016 The enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl-CoA and choline in the cytoplasm and the vesicular acetylcholine transporter (VAChT) uptakes the neurotransmitter into synaptic vesicles. Acetylcholine 76-79 solute carrier family 18 member A3 Homo sapiens 170-175 12176068-4 2002 Knowledge of the structure-function relationship in VAChT might enable pharmacological regulation of ACh storage and release at the level of VAChT. Acetylcholine 53-56 solute carrier family 18 member A3 Homo sapiens 141-146 22821666-7 2013 However, alpha-synuclein-immunoreactivity was localized in significantly more vesicular acetylcholine transporter (VAChT)-IR varicosities (88 +- 3%, P < 0.001). Acetylcholine 88-101 solute carrier family 18 member A3 Homo sapiens 115-120 20583990-1 2010 The vesicular acetylcholine transporter (VAChT) is a glycoprotein responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Acetylcholine 14-27 solute carrier family 18 member A3 Homo sapiens 41-46 17092608-1 2007 Trafficking of the vesicular acetylcholine transporter (VAChT) to synaptic vesicles has the potential to regulate storage and release of acetylcholine. Acetylcholine 29-42 solute carrier family 18 member A3 Homo sapiens 56-61 16763548-2 2006 However, the presence of the vesicular transporter (vesicular acetylcholine (ACh) transporter (VAChT)) for both choline and ACh has never been shown in this compartment. Acetylcholine 77-80 solute carrier family 18 member A3 Homo sapiens 95-100 12827358-2 2004 Their function is to allow the transport of acetylcholine (by the vesicular acetylcholine transporter VAChT; SLC18A3) and biogenic amines (by the vesicular monoamine transporters VMAT1 and VMAT2; SLC18A1 and SLC18A2) into secretory vesicles, which then discharge them into the extracellular space by exocytosis. Acetylcholine 44-57 solute carrier family 18 member A3 Homo sapiens 102-107 12827358-2 2004 Their function is to allow the transport of acetylcholine (by the vesicular acetylcholine transporter VAChT; SLC18A3) and biogenic amines (by the vesicular monoamine transporters VMAT1 and VMAT2; SLC18A1 and SLC18A2) into secretory vesicles, which then discharge them into the extracellular space by exocytosis. Acetylcholine 44-57 solute carrier family 18 member A3 Homo sapiens 109-116 23506877-2 2013 Members of the SLC18 family perform this function for acetylcholine (SLC18A3, the vesicular acetylcholine transporter or VAChT) and monoamines such as dopamine and serotonin (SLC18A1 and 2, the vesicular monoamine transporters VMAT1 and 2, respectively). Acetylcholine 54-67 solute carrier family 18 member A3 Homo sapiens 69-76 23506877-2 2013 Members of the SLC18 family perform this function for acetylcholine (SLC18A3, the vesicular acetylcholine transporter or VAChT) and monoamines such as dopamine and serotonin (SLC18A1 and 2, the vesicular monoamine transporters VMAT1 and 2, respectively). Acetylcholine 54-67 solute carrier family 18 member A3 Homo sapiens 121-126 23222296-5 2013 Nicotine-induced ACh production was mediated by alpha7-, alpha3beta2-, and beta3-nAChRs, ChAT and VAChT pathways. Acetylcholine 17-20 solute carrier family 18 member A3 Homo sapiens 98-103 20419436-3 2010 Retention of radiolabeled ACh or vesamicol, mediated by hVAChT in synaptic-like microvesicles of postnuclear supernatant, is measured using filter assays. Acetylcholine 26-29 solute carrier family 18 member A3 Homo sapiens 56-62 15154676-1 2004 This study was designed to evaluate whether the vesicular acetylcholine transporter (VAChT), which packages acetylcholine into synaptic vesicles, can be used as a marker for regenerating motor axon terminal. Acetylcholine 58-71 solute carrier family 18 member A3 Homo sapiens 85-90 14698765-4 2003 Part of the ACh is brought into the vesicle by the vesicular ACh transporter, VAChT, which exchanges two protons for each ACh, but a fraction of the ACh seems to be accumulated by different, unexplored mechanisms. Acetylcholine 12-15 solute carrier family 18 member A3 Homo sapiens 78-83 14698765-4 2003 Part of the ACh is brought into the vesicle by the vesicular ACh transporter, VAChT, which exchanges two protons for each ACh, but a fraction of the ACh seems to be accumulated by different, unexplored mechanisms. Acetylcholine 61-64 solute carrier family 18 member A3 Homo sapiens 78-83 14698765-4 2003 Part of the ACh is brought into the vesicle by the vesicular ACh transporter, VAChT, which exchanges two protons for each ACh, but a fraction of the ACh seems to be accumulated by different, unexplored mechanisms. Acetylcholine 61-64 solute carrier family 18 member A3 Homo sapiens 78-83 11551909-2 2001 This requires the loading of acetylcholine into synaptic vesicles by the vesicular acetylcholine transporter (VAChT). Acetylcholine 29-42 solute carrier family 18 member A3 Homo sapiens 110-115 12143378-8 2002 By analogy, the vesicular acetylcholine transporter (VachT) is similarly localized to the membranes of axon terminals and tubulovesicles in dendrities in the mesopontine tegmental cholinergic nuclei, suggesting that there also may be release of acetylcholine from both dendrities and axons. Acetylcholine 26-39 solute carrier family 18 member A3 Homo sapiens 53-58 11940684-2 2002 METHODS: The authors determined autoradiographically the regional expression of acetylcholine vesicular transporter (VAChT) and monoamine vesicular transporter type 2 (VMAT2) binding sites in postmortem basal ganglia samples from subjects with PSP. Acetylcholine 80-93 solute carrier family 18 member A3 Homo sapiens 117-122 11551909-9 2001 This indicates that specific structural changes in VAChT translate into specific alterations in the intrinsic parameters of transport and in the storage and synaptic release of acetylcholine in vivo. Acetylcholine 177-190 solute carrier family 18 member A3 Homo sapiens 51-56 10885540-1 2000 The synthesis, storage and release of acetylcholine (ACh) requires the expression of several specialized proteins, including choline acetyltransferase (ChAT) and the vesicular ACh transporter (VAChT). Acetylcholine 38-51 solute carrier family 18 member A3 Homo sapiens 166-191 10717638-3 2000 To determine these sites, we used electron microscopy for the immunocytochemical localization of antipeptide antiserum raised against the vesicular acetylcholine transporter (VAchT) that is responsible for the uptake of acetylcholine into storage vesicles. Acetylcholine 148-161 solute carrier family 18 member A3 Homo sapiens 175-180 10885540-1 2000 The synthesis, storage and release of acetylcholine (ACh) requires the expression of several specialized proteins, including choline acetyltransferase (ChAT) and the vesicular ACh transporter (VAChT). Acetylcholine 38-51 solute carrier family 18 member A3 Homo sapiens 193-198 10885540-1 2000 The synthesis, storage and release of acetylcholine (ACh) requires the expression of several specialized proteins, including choline acetyltransferase (ChAT) and the vesicular ACh transporter (VAChT). Acetylcholine 53-56 solute carrier family 18 member A3 Homo sapiens 166-191 10885540-1 2000 The synthesis, storage and release of acetylcholine (ACh) requires the expression of several specialized proteins, including choline acetyltransferase (ChAT) and the vesicular ACh transporter (VAChT). Acetylcholine 53-56 solute carrier family 18 member A3 Homo sapiens 193-198 8071310-2 1994 The distribution of VAChT mRNA coincides with that reported for choline acetyltransferase (ChAT), the enzyme required for acetylcholine biosynthesis, in the peripheral and central cholinergic nervous systems. Acetylcholine 122-135 solute carrier family 18 member A3 Homo sapiens 20-25 9748347-1 1998 The vesicular acetylcholine transporter (VAChT) mediates ACh storage in synaptic vesicles by exchanging cytoplasmic ACh with vesicular protons. Acetylcholine 42-45 solute carrier family 18 member A3 Homo sapiens 4-39 9748347-1 1998 The vesicular acetylcholine transporter (VAChT) mediates ACh storage in synaptic vesicles by exchanging cytoplasmic ACh with vesicular protons. Acetylcholine 57-60 solute carrier family 18 member A3 Homo sapiens 4-39 9748347-1 1998 The vesicular acetylcholine transporter (VAChT) mediates ACh storage in synaptic vesicles by exchanging cytoplasmic ACh with vesicular protons. Acetylcholine 57-60 solute carrier family 18 member A3 Homo sapiens 41-46 9603187-6 1998 Manipulation of VAChT expression in vivo has demonstrated unequivocally the primacy of vesicular exocytosis as the mode of transmitting quanta of acetylcholine at the neuromuscular junction, as in vivo manipulation of acetylcholinesterase levels has demonstrated the importance of acetylcholine metabolism in the regulation of complex functions such as cognition. Acetylcholine 146-159 solute carrier family 18 member A3 Homo sapiens 16-21 9603187-6 1998 Manipulation of VAChT expression in vivo has demonstrated unequivocally the primacy of vesicular exocytosis as the mode of transmitting quanta of acetylcholine at the neuromuscular junction, as in vivo manipulation of acetylcholinesterase levels has demonstrated the importance of acetylcholine metabolism in the regulation of complex functions such as cognition. Acetylcholine 218-231 solute carrier family 18 member A3 Homo sapiens 16-21 8910293-0 1996 Active transport of acetylcholine by the human vesicular acetylcholine transporter. Acetylcholine 20-33 solute carrier family 18 member A3 Homo sapiens 47-82 8910293-1 1996 The characteristics of ATP-dependent transport of acetylcholine (ACh) in homogenates of pheochromocytoma (PC-12) cells stably transfected with the human vesicular acetylcholine transporter (VAChT) cDNA are described. Acetylcholine 50-63 solute carrier family 18 member A3 Homo sapiens 153-188 8910293-1 1996 The characteristics of ATP-dependent transport of acetylcholine (ACh) in homogenates of pheochromocytoma (PC-12) cells stably transfected with the human vesicular acetylcholine transporter (VAChT) cDNA are described. Acetylcholine 50-63 solute carrier family 18 member A3 Homo sapiens 190-195 8910293-5 1996 The kinetics of [3H]ACh uptake by human VAChT were saturable, exhibiting an apparent Km of 0.97 +/- 0.1 mM and Vmax of 0.58 +/- 0.04 nmol/min/mg. Acetylcholine 20-23 solute carrier family 18 member A3 Homo sapiens 40-45 10594838-8 1999 The first intron of the ChAT gene encompasses the open reading frame encoding another protein, vesicular acetylcholine transporter (VAChT), which is responsible for the transportation of acetylcholine from the cytoplasm into the synaptic vesicles. Acetylcholine 105-118 solute carrier family 18 member A3 Homo sapiens 132-137 34943989-1 2021 BACKGROUND: Presynaptic forms of congenital myasthenic syndromes (CMS) due to pathogenic variants in SLC18A3 impairing the synthesis and recycling of acetylcholine (ACh) have recently been described. Acetylcholine 150-163 solute carrier family 18 member A3 Homo sapiens 101-108 34943989-1 2021 BACKGROUND: Presynaptic forms of congenital myasthenic syndromes (CMS) due to pathogenic variants in SLC18A3 impairing the synthesis and recycling of acetylcholine (ACh) have recently been described. Acetylcholine 165-168 solute carrier family 18 member A3 Homo sapiens 101-108 34943989-2 2021 SLC18A3 encodes the vesicular ACh transporter (VAChT), modulating the active transport of ACh at the neuromuscular junction, and homozygous loss of VAChT leads to lethality. Acetylcholine 90-93 solute carrier family 18 member A3 Homo sapiens 0-7 34943989-2 2021 SLC18A3 encodes the vesicular ACh transporter (VAChT), modulating the active transport of ACh at the neuromuscular junction, and homozygous loss of VAChT leads to lethality. Acetylcholine 90-93 solute carrier family 18 member A3 Homo sapiens 20-45 34943989-2 2021 SLC18A3 encodes the vesicular ACh transporter (VAChT), modulating the active transport of ACh at the neuromuscular junction, and homozygous loss of VAChT leads to lethality. Acetylcholine 90-93 solute carrier family 18 member A3 Homo sapiens 47-52 34943989-10 2021 This in turn implicates the importance of proper VAChT-mediated synthesis and recycling of ACh for lipid homeostasis in muscle cells. Acetylcholine 91-94 solute carrier family 18 member A3 Homo sapiens 49-54 35174565-2 2022 ACh is released from cholinergic nerves by vesicular ACh transporter (VAChT), but ACh release from the NNCS is mediated by organic cation transporter (OCT). Acetylcholine 0-3 solute carrier family 18 member A3 Homo sapiens 43-68 35174565-2 2022 ACh is released from cholinergic nerves by vesicular ACh transporter (VAChT), but ACh release from the NNCS is mediated by organic cation transporter (OCT). Acetylcholine 0-3 solute carrier family 18 member A3 Homo sapiens 70-75