PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33380469-9	2021	These findings provide mechanistic insights into how CHRNA3 risk alleles can increase the risk of tobacco dependence and smoking-related diseases in human smokers.SIGNIFICANCE STATEMENTAllelic variation in CHRNA3, which encodes the alpha3 nicotinic acetylcholine receptor (nAChR) subunit gene, increases risk of tobacco dependence but underlying mechanisms are unclear.	Acetylcholine	249-262	cholinergic receptor nicotinic alpha 3 subunit	Homo sapiens	206-212	
34383618-4	2021	RESULTS: Four cases showed mutations in the alpha3 and beta4 nicotinic acetylcholine receptor (etaAChR) subunits (CHRNA3 and CHRNB4, respectively) on chromosome 15q24.	Acetylcholine	71-84	cholinergic receptor nicotinic alpha 3 subunit	Homo sapiens	114-120	
34206324-1	2021	The gene cluster region, CHRNA3/CHRNA5/CHRNB4, encoding for nicotinic acetylcholine receptor (nAChR) subunits, contains several genetic variants linked to nicotine addiction and brain disorders.	Acetylcholine	70-83	cholinergic receptor nicotinic alpha 3 subunit	Homo sapiens	25-31	
35222535-1	2022	Objective: To investigate the effects of genetic polymorphisms of human nicotinic acetylcholine receptor subunits alpha3, alpha4 and alpha5, which are encoded by CHRNA3, CHRNA4 CHRNA5 genes, respectively, on nicotine addiction and outcomes of pharmacological treatments for smoking cessation.	Acetylcholine	82-95	cholinergic receptor nicotinic alpha 3 subunit	Homo sapiens	162-168	
31708116-2	2019	Here, using whole-exome sequencing, we identified three different biallelic mutations in CHRNA3, which encodes the alpha3 subunit of the nicotinic acetylcholine receptor, in five affected individuals from three unrelated families with functional lower urinary tract obstruction and secondary CAKUT.	Acetylcholine	147-160	cholinergic receptor nicotinic alpha 3 subunit	Homo sapiens	89-95	
31708116-6	2019	Although the importance of acetylcholine signaling in normal bladder function has been recognized, we demonstrate for the first time that mutations in CHRNA3 can cause bladder dysfunction, urinary tract malformations, and dysautonomia.	Acetylcholine	27-40	cholinergic receptor nicotinic alpha 3 subunit	Homo sapiens	151-157	
19628475-3	2009	Since neuronal acetylcholine receptors (nAChRs) are part of the glutamatergic pathway, we searched for sequence variants in CHRNA3, CHRNA4 and CHRNB4 genes, encoding neuronal nicotinic AChR subunits, in 245 SALS patients and in 450 controls.	Acetylcholine	15-28	cholinergic receptor nicotinic alpha 3 subunit	Homo sapiens	124-130