PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31708116-2 2019 Here, using whole-exome sequencing, we identified three different biallelic mutations in CHRNA3, which encodes the alpha3 subunit of the nicotinic acetylcholine receptor, in five affected individuals from three unrelated families with functional lower urinary tract obstruction and secondary CAKUT. Acetylcholine 147-160 cholinergic receptor nicotinic alpha 3 subunit Homo sapiens 89-95 33380469-9 2021 These findings provide mechanistic insights into how CHRNA3 risk alleles can increase the risk of tobacco dependence and smoking-related diseases in human smokers.SIGNIFICANCE STATEMENTAllelic variation in CHRNA3, which encodes the alpha3 nicotinic acetylcholine receptor (nAChR) subunit gene, increases risk of tobacco dependence but underlying mechanisms are unclear. Acetylcholine 249-262 cholinergic receptor nicotinic alpha 3 subunit Homo sapiens 206-212 31708116-6 2019 Although the importance of acetylcholine signaling in normal bladder function has been recognized, we demonstrate for the first time that mutations in CHRNA3 can cause bladder dysfunction, urinary tract malformations, and dysautonomia. Acetylcholine 27-40 cholinergic receptor nicotinic alpha 3 subunit Homo sapiens 151-157 34383618-4 2021 RESULTS: Four cases showed mutations in the alpha3 and beta4 nicotinic acetylcholine receptor (etaAChR) subunits (CHRNA3 and CHRNB4, respectively) on chromosome 15q24. Acetylcholine 71-84 cholinergic receptor nicotinic alpha 3 subunit Homo sapiens 114-120 19628475-3 2009 Since neuronal acetylcholine receptors (nAChRs) are part of the glutamatergic pathway, we searched for sequence variants in CHRNA3, CHRNA4 and CHRNB4 genes, encoding neuronal nicotinic AChR subunits, in 245 SALS patients and in 450 controls. Acetylcholine 15-28 cholinergic receptor nicotinic alpha 3 subunit Homo sapiens 124-130 35222535-1 2022 Objective: To investigate the effects of genetic polymorphisms of human nicotinic acetylcholine receptor subunits alpha3, alpha4 and alpha5, which are encoded by CHRNA3, CHRNA4 CHRNA5 genes, respectively, on nicotine addiction and outcomes of pharmacological treatments for smoking cessation. Acetylcholine 82-95 cholinergic receptor nicotinic alpha 3 subunit Homo sapiens 162-168 34206324-1 2021 The gene cluster region, CHRNA3/CHRNA5/CHRNB4, encoding for nicotinic acetylcholine receptor (nAChR) subunits, contains several genetic variants linked to nicotine addiction and brain disorders. Acetylcholine 70-83 cholinergic receptor nicotinic alpha 3 subunit Homo sapiens 25-31