PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18024550-7	2008	Additional experiments using the I(K(ACh)) blocker tertiapin demonstrated that I(K(ACh)) can contribute to the negative inotropy following S1P activation of S1P(1) (perhaps through G(ibetagamma) subunits).	Acetylcholine	83-86	sphingosine-1-phosphate receptor 1	Mus musculus	139-142	
21602610-3	2011	However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left.	Acetylcholine	76-89	sphingosine-1-phosphate receptor 1	Mus musculus	28-31	
21602610-3	2011	However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left.	Acetylcholine	91-94	sphingosine-1-phosphate receptor 1	Mus musculus	28-31	
21602610-3	2011	However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left.	Acetylcholine	159-162	sphingosine-1-phosphate receptor 1	Mus musculus	28-31	
18024550-7	2008	Additional experiments using the I(K(ACh)) blocker tertiapin demonstrated that I(K(ACh)) can contribute to the negative inotropy following S1P activation of S1P(1) (perhaps through G(ibetagamma) subunits).	Acetylcholine	83-86	sphingosine-1-phosphate receptor 1	Mus musculus	157-160	
18024550-8	2008	Mathematical modeling of the effects of S1P on APD in the mouse ventricle suggests that shortening of APD (e.g., as induced by I(K(ACh))) can reduce L-type calcium current and thus can decrease the intracellular Ca(2+) concentration ([Ca(2+)](i)) transient.	Acetylcholine	131-134	sphingosine-1-phosphate receptor 1	Mus musculus	40-43	
18024550-10	2008	In summary, these findings suggest that the negative inotropy observed in S1P-treated adult mouse ventricular myocytes may consist of two distinctive components: 1) one pathway that acts via G(i) to reduce L-type calcium channel current, blunt calcium-induced calcium release, and decrease [Ca(2+)](i); and 2) a second pathway that acts via G(i) to activate I(K(ACh)) and reduce APD.	Acetylcholine	362-365	sphingosine-1-phosphate receptor 1	Mus musculus	74-77	
17322125-5	2007	We found that S1P administration on nonsensitized mouse bronchi does not cause any direct effect on bronchial tone, while a significant increase in Ach-induced contraction occurs after S1P challenge.	Acetylcholine	148-151	sphingosine-1-phosphate receptor 1	Mus musculus	185-188