PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21602610-3 2011 However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left. Acetylcholine 76-89 sphingosine-1-phosphate receptor 1 Mus musculus 28-31 21602610-3 2011 However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left. Acetylcholine 91-94 sphingosine-1-phosphate receptor 1 Mus musculus 28-31 21602610-3 2011 However, in the presence of S1P (10(-6) M), the BSM contractions induced by acetylcholine (ACh) and endothelin-1 (ET-1) were significantly augmented: both the ACh and ET-1 concentration-response curves were significantly shifted to the left. Acetylcholine 159-162 sphingosine-1-phosphate receptor 1 Mus musculus 28-31 18024550-7 2008 Additional experiments using the I(K(ACh)) blocker tertiapin demonstrated that I(K(ACh)) can contribute to the negative inotropy following S1P activation of S1P(1) (perhaps through G(ibetagamma) subunits). Acetylcholine 83-86 sphingosine-1-phosphate receptor 1 Mus musculus 139-142 18024550-7 2008 Additional experiments using the I(K(ACh)) blocker tertiapin demonstrated that I(K(ACh)) can contribute to the negative inotropy following S1P activation of S1P(1) (perhaps through G(ibetagamma) subunits). Acetylcholine 83-86 sphingosine-1-phosphate receptor 1 Mus musculus 157-160 18024550-8 2008 Mathematical modeling of the effects of S1P on APD in the mouse ventricle suggests that shortening of APD (e.g., as induced by I(K(ACh))) can reduce L-type calcium current and thus can decrease the intracellular Ca(2+) concentration ([Ca(2+)](i)) transient. Acetylcholine 131-134 sphingosine-1-phosphate receptor 1 Mus musculus 40-43 18024550-10 2008 In summary, these findings suggest that the negative inotropy observed in S1P-treated adult mouse ventricular myocytes may consist of two distinctive components: 1) one pathway that acts via G(i) to reduce L-type calcium channel current, blunt calcium-induced calcium release, and decrease [Ca(2+)](i); and 2) a second pathway that acts via G(i) to activate I(K(ACh)) and reduce APD. Acetylcholine 362-365 sphingosine-1-phosphate receptor 1 Mus musculus 74-77 17322125-5 2007 We found that S1P administration on nonsensitized mouse bronchi does not cause any direct effect on bronchial tone, while a significant increase in Ach-induced contraction occurs after S1P challenge. Acetylcholine 148-151 sphingosine-1-phosphate receptor 1 Mus musculus 185-188