PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34008839-2 2021 The alpha7 nicotinic acetylcholine receptor (alpha7nAChR) can modulate immune responses in both the periphery and the brain. Acetylcholine 21-34 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 45-56 33598912-1 2021 BACKGROUND AND PURPOSE: Alpha 7 nicotinic acetylcholine receptors (CHRNA7) suppress inflammation through diverse pathways in immune cells, so is potentially involved in a number of inflammatory diseases. Acetylcholine 42-55 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 67-73 33995108-1 2021 The alpha7 nicotinic acetylcholine receptor (alpha7nAChR) belongs to the superfamily of cys loop cationic ligand-gated channels, which consists of homogeneous alpha7 subunits. Acetylcholine 21-34 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 4-10 33992630-3 2021 Treatment with cynandione A and the specific alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist PHA-543613 remarkably reduced overexpression of proinflammatory cytokines, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta in lipopolysaccharide (LPS)-treated RAW264.7 cells and primary peritoneal macrophages, and endotoxemic mice. Acetylcholine 62-75 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 86-98 34007230-2 2021 Chronic intermittent hypoxia (CIH), the main pathophysiological characteristics of OSA, is closely related to cognitive dysfunction and may be mediated by alpha-7 nicotinic acetylcholine receptors (alpha7nAChR). Acetylcholine 173-186 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 198-209 33607168-4 2021 KA antagonizes alpha7 nicotinic acetylcholine receptor (alpha7nAChR). Acetylcholine 32-45 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 56-67 33995108-1 2021 The alpha7 nicotinic acetylcholine receptor (alpha7nAChR) belongs to the superfamily of cys loop cationic ligand-gated channels, which consists of homogeneous alpha7 subunits. Acetylcholine 21-34 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 45-56 34055878-2 2021 The autonomic nervous system was reported to be involved in AP, and the vagus nerve could exert anti-inflammatory effects through alpha7 nicotinic acetylcholine receptor (alpha7nAChR) signaling. Acetylcholine 147-160 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 171-182 33354763-2 2021 We assessed if low doses of the partial alpha4beta2 nicotinic acetylcholine receptor (nAChR) agonist, cytisine attenuates apoptotic ER stress and exerts neuroprotection in substantia nigra pars compacta (SNc) DA neurons. Acetylcholine 62-75 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 86-91 31839230-4 2021 METHODS: Acute hyperglycemia was induced in wild-type C57BL6 or acetylcholine-receptor knockout (alpha7nAChR-/-) mice by intraperitoneal injection of glucose. Acetylcholine 64-77 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 97-108 33928103-3 2021 Positive allosteric modulators (PAM) are pharmacological agents that inhibit desensitization of the nicotinic acetylcholine receptor (alpha7-nAChR), the main anti-inflammatory feature within the cholinergic anti-inflammatory pathway, and may augment alpha7-dependent cholinergic tone to generate therapeutic benefits in SLE. Acetylcholine 110-123 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 141-146 33844281-1 2021 BACKGROUND AND PURPOSE: alpha4beta2 nicotinic acetylcholine receptor (nAChR), a subtype of the ligand-gated ion channel, is abundantly expressed in the brain and implicated in several neurological disorders. Acetylcholine 46-59 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 70-75 33902624-1 2021 BACKGROUND: The alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) negatively regulates the synthesis and release of pro-inflammatory cytokines by immune cells. Acetylcholine 33-46 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 57-69 33739565-3 2021 Nicotinic acetylcholine receptors (nAChRs) can modulate immune cells, including neutrophils, functions, therefore, nAChR ligands are considered as the potent agents for therapy of inflammation. Acetylcholine 10-23 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 35-40 32893406-3 2021 The vagus nerve innervating the airways releases acetylcholine (ACh) or neuropeptides (i.e. CGRP) via pulmonary C fibres (PCFs), which could regulate ILC2 activity upon binding the alpha7 nicotinic acetylcholine receptor (alpha7nAChR, coded by Chrna7) or neuropeptide receptors. Acetylcholine 49-62 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 222-233 33641516-2 2021 Reduction of neuroinflammation by activation of alpha-7 nicotinic acetylcholine receptor (alpha-7 nAchR) reduced acute neuronal injury and sensorimotor dysfunction in mice with BF 1-day after stroke. Acetylcholine 66-79 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 90-103 32893406-3 2021 The vagus nerve innervating the airways releases acetylcholine (ACh) or neuropeptides (i.e. CGRP) via pulmonary C fibres (PCFs), which could regulate ILC2 activity upon binding the alpha7 nicotinic acetylcholine receptor (alpha7nAChR, coded by Chrna7) or neuropeptide receptors. Acetylcholine 49-62 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 244-250 33440720-1 2021 The nicotinic acetylcholine receptor (nAChR) is one of the receptors of acetylcholine (ACh), and nicotine (NIC) acts as an agonist of this receptor. Acetylcholine 14-27 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 38-43 33239400-0 2021 Implications of oligomeric amyloid-beta (oAbeta42) signaling through alpha7beta2-nicotinic acetylcholine receptors (nAChR) on basal forebrain cholinergic neuronal intrinsic excitability and cognitive decline. Acetylcholine 91-104 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 116-121 33239400-3 2021 In this study we tested the hypothesis that the oligomeric form of amyloid-beta (oAbeta42), interacting with alpha7-containing nicotinic acetylcholine receptor (nAChR) subtypes, leads to subnucleus-specific alterations in BFCN excitability and impaired cognition. Acetylcholine 137-150 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 161-166 33477969-3 2021 This study reports that the activation of the alpha7 nicotinic acetylcholine receptor (alpha7nAChR) with the delete allosteric agonistic-positive allosteric modulator, GAT107, decreases the bacterial burden in mouse lungs by improving hyperoxia-induced lung redox imbalance. Acetylcholine 63-76 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 87-98 33440720-1 2021 The nicotinic acetylcholine receptor (nAChR) is one of the receptors of acetylcholine (ACh), and nicotine (NIC) acts as an agonist of this receptor. Acetylcholine 39-42 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 4-36 33952828-7 2021 The effect of nicotine was blocked by the alpha4beta2 nicotinic acetylcholine receptor (nAChR) antagonist dihydro-beta-erythroidine, alpha7 nAChR antagonist methyllycaconitine, or intracellular perfusion with the Ca2+ chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid (BAPTA). Acetylcholine 64-77 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 88-93 33414508-1 2021 Vagal circuit-alpha7 nicotinic acetylcholine receptor (alpha7nAChR, coded by Chrna7) signaling can modulate lung proinflammatory responses. Acetylcholine 31-44 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 55-66 33414508-1 2021 Vagal circuit-alpha7 nicotinic acetylcholine receptor (alpha7nAChR, coded by Chrna7) signaling can modulate lung proinflammatory responses. Acetylcholine 31-44 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 77-83 32950676-3 2020 In this study, we aim to examine the effect of alpha7 nicotinic acetylcholine receptor (alpha7nAChR) stimulation within the pancreas during AP. Acetylcholine 64-77 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 88-99 33447242-1 2020 Inhibition of Ras farnesylation in acute has been found to upregulate the alpha7 nicotinic acetylcholine receptor (alpha7nAChR) activity. Acetylcholine 91-104 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 115-126 33339145-2 2020 The alpha3beta4 nicotinic acetylcholine receptor (nAChR) is strongly associated with nicotine reward and withdrawal symptom. Acetylcholine 26-39 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 50-55 32857757-2 2020 A novel in vitro assay has been developed based on the binding of post-synaptically acting alpha-neurotoxins to nicotinic acetylcholine receptor (nAChR), and the ability of antivenoms to prevent this binding. Acetylcholine 122-135 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 146-151 32712126-4 2020 First, we verified the expression and distribution of the alpha7 nicotinic acetylcholine receptor (nAChR), a gene product of the CHRNA7, in cortical and subcortical areas. Acetylcholine 75-88 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 99-104 32712126-4 2020 First, we verified the expression and distribution of the alpha7 nicotinic acetylcholine receptor (nAChR), a gene product of the CHRNA7, in cortical and subcortical areas. Acetylcholine 75-88 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 129-135 32705242-2 2020 alpha7 nicotinic acetylcholine receptor (alpha7nAChR) is known to regulate multiple aspects of immune function. Acetylcholine 17-30 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 41-52 32988984-1 2020 Previous reports indicate that nicotine reward is mediated through alpha4beta2*, alpha6beta2*, and alpha4alpha6beta2* nicotinic acetylcholine receptors (nAChRs) (*, indicates that additional nAChR subunits may be present). Acetylcholine 128-141 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 153-158 32413437-2 2020 The alpha7 nicotinic acetylcholine receptor (nAChR) is crucial in the regulation of the neuroprotective role in microglia. Acetylcholine 21-34 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 45-50 32258279-0 2020 RNA sequencing data describing transcriptional changes in aorta of ApoE-/- mice after alpha 7 nicotinic acetylcholine receptor (alpha7nAChR) stimulation. Acetylcholine 104-117 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 128-139 32373212-11 2020 The alpha7 nicotine acetylcholine receptor (alpha7nAChR) was highly expressed in HAECs and its antagonist could effectively relieve nicotine-induced EndMT and atherosclerotic lesions in mice. Acetylcholine 20-33 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 44-55 32708537-2 2020 alpha7 nicotinic acetylcholine receptor (nAChR) may contribute to insulin sensitivity but its role in the pathogenesis of T2D remains undefined. Acetylcholine 17-30 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 41-46 32304995-2 2020 It is potently activated by acetylcholine (ACh) addressing muscarinic receptors with a currently less defined role of nicotinic ACh receptors (nAChR). Acetylcholine 43-46 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 118-141 32522255-3 2020 Vagal-alpha7 nicotinic acetylcholine receptor (alpha7nAChR) signaling plays a key role in regulating lung infection and inflammation; however, whether this pathway could regulate LSCs remains unknown. Acetylcholine 23-36 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 47-58 31580099-2 2019 One potential therapeutic for AUD is the alpha3beta4 nicotinic acetylcholine receptor (nAChR) antagonist 18-methoxycoronaridine (18-MC). Acetylcholine 63-76 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 87-92 31817275-1 2019 Experimental autoimmune encephalomyelitis (EAE) is attenuated in nicotinic acetylcholine receptor (nAChR) alpha9 subunit knock-out (alpha9 KO) mice. Acetylcholine 75-88 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 99-104 31917144-1 2020 AIM: The present study aimed to explore the ameliorative role of alpha7 (alpha7) neuronal nicotinic acetylcholine receptor (nAChR) modulation in epilepsy and associated comorbidities in postpentylenetetrazole (PTZ)-kindled mice. Acetylcholine 100-113 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 124-129 31930655-1 2020 Recent studies have showed that alpha5 nicotinic acetylcholine receptor (alpha5-nAChR) is closely associated with nicotine-related lung cancer. Acetylcholine 49-62 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 80-85 31913329-1 2020 The activation of nicotinic acetylcholine receptor alpha7 subunit (alpha7nAChR) has been associated to anti-inflammatory response in macrophages. Acetylcholine 28-41 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 67-78 32468495-3 2020 The heterozygous 15q13.3 microdeletion syndrome suggests that diminished or impaired transduction of the acetylcholine (ACh) signal by the alpha7 nAChR can be a pathogenic mechanism of ASD. Acetylcholine 105-118 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 139-151 32468495-3 2020 The heterozygous 15q13.3 microdeletion syndrome suggests that diminished or impaired transduction of the acetylcholine (ACh) signal by the alpha7 nAChR can be a pathogenic mechanism of ASD. Acetylcholine 120-123 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 139-151 31744841-2 2019 Nicotinic acetylcholine receptor (nAChR) activity is capable of modulating such intra-VTA transmission, but the mechanisms are unclear. Acetylcholine 10-23 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 34-39 31560162-6 2019 Choline is also the precursor for acetylcholine, a neurotransmitter which activates the alpha7 nicotinic acetylcholine receptor (alpha7nAchR), and also acts as an agonist for the Sigma-1 R (sigma1R). Acetylcholine 34-47 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 129-140 31560162-6 2019 Choline is also the precursor for acetylcholine, a neurotransmitter which activates the alpha7 nicotinic acetylcholine receptor (alpha7nAchR), and also acts as an agonist for the Sigma-1 R (sigma1R). Acetylcholine 105-118 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 129-140 31655281-1 2019 BACKGROUND: Previous studies have shown that alpha7 nicotinic acetylcholine receptor (nAChR) has a critical role in the regulation of pain sensitivity and neuroinflammation. Acetylcholine 62-75 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 86-91 31302720-1 2019 RATIONALE: The alpha7 nicotinic acetylcholine receptor (nAChR) has been implicated as a target in modulating nicotine reward. Acetylcholine 32-45 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 56-61 31302720-11 2019 In addition, the Type II alpha7 nAChR PAM PNU120596 attenuated nicotine reward suggesting that endogenous acetylcholine/choline tone is sufficient to reduce nicotine CPP. Acetylcholine 106-119 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 32-37 31934123-1 2019 The cholinergic pathway neurotransmitter acetylcholine (ACh) regulates the inflammatory cascade through a specific alpha7 nicotinic acetylcholine receptor (alpha7nAChR). Acetylcholine 41-54 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 115-154 31276191-5 2019 With an IC50 of 1.6 mum, OSK1 inhibits acetylcholine-induced current through mouse muscle-type nAChR heterologously expressed in Xenopus oocytes. Acetylcholine 39-52 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 95-100 30496781-3 2019 Growing research suggests that 18-Methoxycoronaridine (18-MC), an alpha3beta4 nicotinic acetylcholine receptor (nAChR) antagonist, may be effective at reducing ethanol consumption. Acetylcholine 88-101 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 112-117 31260875-0 2019 Stimulation of alpha 7 nicotinic acetylcholine receptor (alpha7nAChR) inhibits atherosclerosis via immunomodulatory effects on myeloid cells. Acetylcholine 33-46 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 57-68 31260875-1 2019 BACKGROUND AND AIMS: Alpha 7 nicotinic acetylcholine receptor (alpha7nAChR) stimulation can regulate acute inflammation, and lack of alpha7nAChR accelerates atherosclerosis in mice. Acetylcholine 39-52 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 63-74 31934123-1 2019 The cholinergic pathway neurotransmitter acetylcholine (ACh) regulates the inflammatory cascade through a specific alpha7 nicotinic acetylcholine receptor (alpha7nAChR). Acetylcholine 41-54 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 156-167 31934123-1 2019 The cholinergic pathway neurotransmitter acetylcholine (ACh) regulates the inflammatory cascade through a specific alpha7 nicotinic acetylcholine receptor (alpha7nAChR). Acetylcholine 56-59 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 115-154 31934123-1 2019 The cholinergic pathway neurotransmitter acetylcholine (ACh) regulates the inflammatory cascade through a specific alpha7 nicotinic acetylcholine receptor (alpha7nAChR). Acetylcholine 56-59 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 156-167 31116647-10 2019 Our findings are consistent with a role for the alpha7-nAChR in types of neurodevelopmental and auditory processing disorders and we identify potential neural targets for intervention.NEW & NOTEWORTHY Disrupted signaling via the alpha7-nicotinic acetylcholine receptor (alpha7-nAChR) is associated with neurodevelopmental disorders that include impaired auditory processing. Acetylcholine 246-259 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 48-60 31116647-10 2019 Our findings are consistent with a role for the alpha7-nAChR in types of neurodevelopmental and auditory processing disorders and we identify potential neural targets for intervention.NEW & NOTEWORTHY Disrupted signaling via the alpha7-nicotinic acetylcholine receptor (alpha7-nAChR) is associated with neurodevelopmental disorders that include impaired auditory processing. Acetylcholine 246-259 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 270-282 30333556-1 2019 The alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) is a ligand-gated Ca2+-permeable homopentameric ion channel implicated in cognition and neuropsychiatric disorders. Acetylcholine 21-34 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 45-57 30971711-11 2019 Released ACh inhibited macrophage and neutrophil infiltration likely by activation of alpha7nAChR on macrophages and M2AChR. Acetylcholine 9-12 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 86-97 30359640-4 2019 Here we have shown that AMPH enantiomers bind to the alpha7 nAChR and competitively inhibit acetylcholine responses. Acetylcholine 92-105 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 53-65 30608952-4 2019 In inhibiting the Ca2+ responses induced by acetylcholine in Neuro2a cells expressing the mouse adult alpha1beta1epsilondelta nAChR or human alpha7 nAChR, BBIQAs1 and 2 had similar potencies to d-TC (IC50s in the range 0.75-3.08 muM). Acetylcholine 44-57 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 126-131 30967878-0 2019 Short-Term High-Fat Diet Consumption Reduces Hypothalamic Expression of the Nicotinic Acetylcholine Receptor alpha7 Subunit (alpha7nAChR) and Affects the Anti-inflammatory Response in a Mouse Model of Sepsis. Acetylcholine 86-99 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 125-136 30967878-3 2019 Here, we show for the first time, that short-term HFD consumption impairs early nicotinic acetylcholine receptor alpha7 subunit (alpha7nAChR)- mediated signaling, one of the major components of the cholinergic anti-inflammatory pathway, with a focus on hypothalamic inflammation and innate immune response. Acetylcholine 90-103 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 129-140 28264149-3 2018 EXPERIMENTAL APPROACH: As the alpha7 subunit of the nicotinic ACh receptor (nAChR) is highly expressed in hippocampus, we determined whether blocking alpha7 nAChRs could reverse the effects of increased ACh signalling in anxiety- and depression-related behaviours in mice. Acetylcholine 62-65 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 76-81 30538698-2 2018 Signals in the vagus and splenic nerves are relayed by choline acetyltransferase+ T cells that release acetylcholine, the cognate ligand for alpha7 nicotinic acetylcholine subunit-containing receptors (alpha7nAChR), and suppress TNF release in macrophages. Acetylcholine 103-116 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 141-200 30538698-2 2018 Signals in the vagus and splenic nerves are relayed by choline acetyltransferase+ T cells that release acetylcholine, the cognate ligand for alpha7 nicotinic acetylcholine subunit-containing receptors (alpha7nAChR), and suppress TNF release in macrophages. Acetylcholine 103-116 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 202-213 28955208-1 2017 The alpha9 and alpha10 nicotinic acetylcholine receptor (nAChR) subunits are likely to be the evolutionary precursors to the entire cys-loop superfamily of ligand-gated ion channels, which includes acetylcholine, GABA, glycine and serotonin ionotropic receptors. Acetylcholine 33-46 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 57-62 29680908-2 2018 The cholinergic anti-inflammatory pathway (CHAIP) is a physiological mechanism by which the central nervous system regulates immune response through the vagus nerve and acetylcholine; the alpha7-nicotinic acetylcholine receptor (alpha7nAChR) is the main component of CHAIP; GTS-21, a synthetic alpha7nAChR selective agonist, has repeatedly shown its powerful anti-inflammatory effect. Acetylcholine 169-182 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 188-227 29680908-2 2018 The cholinergic anti-inflammatory pathway (CHAIP) is a physiological mechanism by which the central nervous system regulates immune response through the vagus nerve and acetylcholine; the alpha7-nicotinic acetylcholine receptor (alpha7nAChR) is the main component of CHAIP; GTS-21, a synthetic alpha7nAChR selective agonist, has repeatedly shown its powerful anti-inflammatory effect. Acetylcholine 169-182 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 294-305 29316656-3 2018 The peptide effectively inhibited (IC50 ~ 19 nM) calcium response of muscle nAChR evoked by 30 muM (EC100) acetylcholine but was less potent (IC50 ~ 3 muM) at alpha7 nAChR activated by 10 muM (EC50) acetylcholine and had a low affinity to alpha4beta2 and alpha3-containing nAChR, as well as to GABAA or 5HT3 receptors. Acetylcholine 107-120 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 76-81 29316656-3 2018 The peptide effectively inhibited (IC50 ~ 19 nM) calcium response of muscle nAChR evoked by 30 muM (EC100) acetylcholine but was less potent (IC50 ~ 3 muM) at alpha7 nAChR activated by 10 muM (EC50) acetylcholine and had a low affinity to alpha4beta2 and alpha3-containing nAChR, as well as to GABAA or 5HT3 receptors. Acetylcholine 199-212 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 76-81 27511019-5 2016 Using in vitro electrophysiology and optogenetics in mouse brain slices, we found that ACh generated nicotinic ACh receptor (nAChR)-mediated depolarizing potentials and muscarinic ACh receptor (mAChR)-mediated hyperpolarizing potentials in AC L5B corticocallosal neurons. Acetylcholine 87-90 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 125-130 28725182-5 2017 In peripheral blood mononuclear cells from nAChR gene-deficient mice, we demonstrated that inhibition of ATP-dependent release of IL-1beta by acetylcholine (ACh), nicotine and PC depends on subunits alpha7, alpha9 and alpha10. Acetylcholine 142-155 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 43-48 28386326-7 2017 We found that Ach inhibited LPS-induced IL-1beta and IL-6 elevation and promoted IL-4 and IL-10 production and that knockdown of the alpha7 nAChR abolished these effects of Ach. Acetylcholine 173-176 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 140-145 28386326-8 2017 In addition, Ach decreased LPS-induced Iba-1 expression and increased Arg-1 levels in an alpha7 nAChR-dependent manner. Acetylcholine 13-16 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 96-101 28386326-9 2017 The LPS-inhibited activation of JAK2/STAT3 and PI3K/Akt was also rescued by Ach, an effect that was blocked by knockdown of the alpha7 nAChR. Acetylcholine 76-79 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 128-140 28438486-1 2017 We show that amyloid-beta1-42 (Abeta42) triggers a conformational change in the scaffolding protein filamin A (FLNA) to induce FLNA associations with alpha7-nicotinic acetylcholine receptor (alpha7nAChR) and toll-like receptor 4 (TLR4). Acetylcholine 167-180 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 191-202 28386326-11 2017 Finally, the levels of miR-124 and downstream targets C/EBPalpha and PU.1 were significantly enhanced in LPS-treated BV-2 microglia, and the effect of Ach on this signaling pathway was blocked by alpha7 nAChR knockdown as expected. Acetylcholine 151-154 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 196-208 27535978-9 2016 These results suggest that central mAChR and alpha7nAChR, which are activated by accumulated acetylcholine resulting from AChEI, were responsible for the protective effect of AChEIs on APAP-induced liver injury. Acetylcholine 93-106 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 45-56 27459936-2 2016 Agonists of alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) are under development as symptomatic treatments for AD, and clinical findings suggest that alpha7 nAChR agonists may improve cognitive functions in AD patients. Acetylcholine 29-42 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 54-66 27511019-6 2016 In corticocollicular neurons, ACh release also generated nAChR-mediated depolarizing potentials. Acetylcholine 30-33 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 57-62 26499847-6 2015 Culture experiments with isolated neonatal cardiomyocytes showed that acetylcholine, but not noradrenaline, inhibited hypoxia-induced release of HMGB1 via a alpha7nAchR-dependent pathway. Acetylcholine 70-83 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 163-168 26471256-7 2016 In contrast, alpha7, but not beta2, subunit knockdown effectively reversed the effect of increased ACh signaling in a mouse model of depression. Acetylcholine 99-102 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 13-19 26471256-9 2016 In contrast, stimulation of alpha7 nAChRs by acetylcholine may mediate the increased depression-like behaviors observed during the hypercholinergic state observed in depressed individuals. Acetylcholine 45-58 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 28-34 25363563-5 2016 Comparison of the contribution of different nAChR subunits to acetylcholine (ACh)-induced inward currents indicated that the contributions of the beta2 and/or beta4 and alpha7 nAChR subunits alter across age. Acetylcholine 62-75 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 44-49 25363563-5 2016 Comparison of the contribution of different nAChR subunits to acetylcholine (ACh)-induced inward currents indicated that the contributions of the beta2 and/or beta4 and alpha7 nAChR subunits alter across age. Acetylcholine 62-75 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 169-181 27061851-0 2016 An acetylcholine alpha7 positive allosteric modulator rescues a schizophrenia-associated brain endophenotype in the 15q13.3 microdeletion, encompassing CHRNA7. Acetylcholine 3-16 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 152-158 26970742-5 2016 RESULTS: We could demonstrate the presence of several nAChR subunits in bone marrow-derived macrophages stimulated with RANKL and M-CSF, and showed that they are capable of producing acetylcholine. Acetylcholine 183-196 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 54-59 25673288-1 2015 Recent evidence reveals a crucial role for acetylcholine and its receptors in the regulation of inflammation, particularly of nicotinic acetylcholine receptor alpha7 (Chrna7) and muscarinic acetylcholine receptor 3 (Chrm3). Acetylcholine 43-56 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 167-173 26206194-3 2015 Activation of nicotinic acetylcholine receptors (nAChRs) by nicotine or specific alpha7 nAChR agonists reduces neuroinflammation. Acetylcholine 24-37 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 81-93 25855181-5 2015 We show that the restricted glomerular application of ACh causes rapid, brief nAChR-mediated excitation of both MTCs and ETCs in the mouse olfactory bulb. Acetylcholine 54-57 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 78-83 24266758-5 2014 Ongoing alpha6beta2* nAChR activation by acetylcholine plays a role in enhancing DA levels, as alpha-conotoxin MII completely abolished evoked DA release in alpha6L9"S slices and decreased spontaneous DA release from striatal synaptosomes. Acetylcholine 41-54 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 21-26 25041479-4 2014 [(3) H]-ACh release was also stimulated using nicotinic agonists, electrical pulses and elevated [KCl]o in hippocampal and cortical slices from rats, wild-type mice and mice lacking alpha5, alpha7, beta2, or beta4 nACh receptor subunits. Acetylcholine 8-11 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 190-196 25046735-7 2014 This nicotine effect was mediated by the activation of non-alpha7 nAChR subtypes, which were not activated by ACh released during LTD-inducing stimulation, and requires the presence of endogenous ACh-induced alpha7 nAChR activation. Acetylcholine 67-70 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 59-65 26202362-0 2015 Acetylcholine Inhibits LPS-Induced MMP-9 Production and Cell Migration via the alpha7 nAChR-JAK2/STAT3 Pathway in RAW264.7 Cells. Acetylcholine 0-13 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 79-91 26322330-11 2015 Taken together, these data provide a mechanism by which phasic ACh release enhances the firing of a subset of hypocretin neurons through postsynaptic nAChRs, but disrupts tonic, presynaptic nAChR-mediated glutamatergic inputs to the overall population of hypocretin neurons, potentially enhancing the signal-to-noise ratio during the response of the nAChR-positive subset of neurons. Acetylcholine 63-66 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 150-155 26322330-11 2015 Taken together, these data provide a mechanism by which phasic ACh release enhances the firing of a subset of hypocretin neurons through postsynaptic nAChRs, but disrupts tonic, presynaptic nAChR-mediated glutamatergic inputs to the overall population of hypocretin neurons, potentially enhancing the signal-to-noise ratio during the response of the nAChR-positive subset of neurons. Acetylcholine 63-66 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 190-195 25352454-1 2015 We previously reported that activated microglia are involved in amyloid-beta (Abeta) clearance and that stimulation of alpha7 nicotinic acetylcholine receptors (nAChR) in microglia enhances Abeta clearance. Acetylcholine 136-149 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 161-166 23842742-2 2013 Alterations in the alpha7-nicotinic acetylcholine receptor (alpha7-nAChR) have been implicated in AD pathology. Acetylcholine 36-49 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 60-72 24733966-2 2014 It has been proved that endogenous neuronal acetylcholine (ACh) could play an anti-inflammatory role, and exogenous cholinergic agonists could weaken macrophages inflammatory response to lipopolysaccharide (LPS) stimulation through activation of alpha7 subunit-containing nicotinic acetylcholine receptor (alpha7nAChR). Acetylcholine 44-57 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 246-317 24733966-2 2014 It has been proved that endogenous neuronal acetylcholine (ACh) could play an anti-inflammatory role, and exogenous cholinergic agonists could weaken macrophages inflammatory response to lipopolysaccharide (LPS) stimulation through activation of alpha7 subunit-containing nicotinic acetylcholine receptor (alpha7nAChR). Acetylcholine 59-62 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 246-317 24733966-5 2014 The results showed that, in RAW264.7 cells incubated with LPS for 20 hours, the secretion of ACh was significantly decreased at 4 h and then gradually increased, accompanied with the enhancement of alpha7nAChR expression level. Acetylcholine 93-96 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 198-209 24289538-6 2014 SV prevented Abeta25-35 -inhibited protein kinase B (Akt) and extracellular signal-related kinase-2 (ERK2) phosphorylation, which was sensitive to alpha7 nicotinic acetylcholine receptor (alpha7nAChR) antagonist MLA. Acetylcholine 164-177 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 188-199 24049141-8 2013 ACh-induced currents were significantly smaller in MPG neurons dissociated from 3-day explant cultured ganglia than from those recorded in neurons dissociated from acutely isolated ganglia; this observation provides direct evidence showing that a decrease in nAChR function was coincident with a decrease in nAChR subunit transcript levels. Acetylcholine 0-3 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 259-264 24049141-8 2013 ACh-induced currents were significantly smaller in MPG neurons dissociated from 3-day explant cultured ganglia than from those recorded in neurons dissociated from acutely isolated ganglia; this observation provides direct evidence showing that a decrease in nAChR function was coincident with a decrease in nAChR subunit transcript levels. Acetylcholine 0-3 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 308-313 23136348-5 2013 I show that most of these cells in the RMS exhibit large nAChR-mediated calcium transients upon application of acetylcholine (ACh). Acetylcholine 111-124 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 57-62 21849351-11 2013 In cultured cardiac microvascular endothelial cells, ACh stimulated the expression of VEGF, phosphorylation of VEGF receptor 2, and tube formation in a manner dependent upon alpha7-nAChR. Acetylcholine 53-56 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 174-186 23004024-2 2013 Recent evidence suggests that alpha7 nicotinic ACh receptor (nAChR) subtypes, which can be activated by an endogenous cholinergic tone comprising ACh and the alpha7 agonist choline, play an important role in chronic pain and inflammation. Acetylcholine 47-50 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 61-66 22910136-4 2012 This nAChR was modeled using Molecular Operating Environment (MOE) package indirectly from mollusca acetylcholine binding protein with mouse neuron alpha7 nAChR as intermediary template. Acetylcholine 100-113 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 5-10 23115222-2 2013 Recent evidence suggests that alpha7 nAChR subtypes, which can be activated by an endogenous cholinergic tone, comprising acetylcholine and the alpha7 nAChR agonist choline, play an important role in subchronic pain and inflammation. Acetylcholine 122-135 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 30-42 22771693-1 2012 AIMS: Functional nicotinic acetylcholine receptors (nAChR) have been identified in airway epithelia and their location in the apical and basolateral membrane makes them targets for acetylcholine released from neuronal and non-neuronal sources. Acetylcholine 27-40 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 52-57 22506481-4 2012 Acetylcholine-evoked [(3) H]-GABA release from SuSC crude synaptosomal preparations is calcium dependent, blocked by the voltage-sensitive calcium channel blocker, cadmium, and the nAChR antagonist mecamylamine, but is unaffected by muscarinic, glutamatergic, P2X and 5-HT3 receptor antagonists. Acetylcholine 0-13 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 181-186 19293145-2 2009 AD is also characterized by a loss of neurons, particularly those expressing nicotinic acetylcholine receptors (nAChRs), thereby leading to a reduction in nAChR numbers. Acetylcholine 87-100 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 112-117 22359587-7 2012 alpha7 nAChR agonists (1 microM acetylcholine, 10 microM choline or 30 nM PNU-282987) impaired intramitochondrial Ca(2+) accumulation and significantly decreased cytochrome c release stimulated with either 90 microM CaCl(2) or 0.5 mM H(2)O(2). Acetylcholine 32-45 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 0-6 22359587-7 2012 alpha7 nAChR agonists (1 microM acetylcholine, 10 microM choline or 30 nM PNU-282987) impaired intramitochondrial Ca(2+) accumulation and significantly decreased cytochrome c release stimulated with either 90 microM CaCl(2) or 0.5 mM H(2)O(2). Acetylcholine 32-45 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 7-12 21270829-1 2011 Acetylcholine (ACh) regulates vital functions of T cells by acting on the nicotinic and muscarinic classes of cholinergic receptors, nAChR and mAChRs, respectively. Acetylcholine 0-13 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 133-138 21270829-1 2011 Acetylcholine (ACh) regulates vital functions of T cells by acting on the nicotinic and muscarinic classes of cholinergic receptors, nAChR and mAChRs, respectively. Acetylcholine 15-18 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 133-138 21146628-9 2011 alpha7 nAChRs were found recruited to immune synapses between human T and B lymphocytes, both of which produced acetylcholine. Acetylcholine 112-125 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 0-6 21056666-3 2011 Here we show, by whole cell patch-clamp recordings from cultured SCG neurons, that both nicotine and acetylcholine-evoked currents through alpha3beta2/beta4-nAChRs are significantly reduced in mdx mice compared to the wild-type, while those through alpha7-nAChR are unaffected. Acetylcholine 101-114 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 249-261 21261967-1 2011 Acetylcholine, the principal vagus neurotransmitter, inhibits inflammation by suppressing the production of pro-inflammatory cytokines through a mechanism dependent on the alpha7 nicotinic acetylcholine receptor subunit (alpha7nAChR) that explains why vagus nerve stimulation is anti-inflammatory in nature. Acetylcholine 0-13 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 221-232 20599770-4 2010 The studies described here evaluated desensitization elicited by low concentrations of epibatidine, nicotine, cytisine or methylcarbachol of brain alpha4beta2-nAChR function measured with acetylcholine-stimulated (86)Rb(+) efflux from mouse thalamic synaptosomes. Acetylcholine 188-201 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 159-164 19820967-4 2009 Extracellular ACh binds to nicotinic (nAChR) and muscarinic receptors (MR). Acetylcholine 14-17 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 38-43 19427310-11 2009 CONCLUSIONS: ACh enhances phagocytic potential while inhibiting immune reactivity via nAChR alpha4/beta2 in mouse macrophages. Acetylcholine 13-16 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 86-91 19374941-8 2009 Of the alpha7nAChR-labeled axons, 47% (37/79) also contained VAChT, suggesting that ACh release is autoregulated through the presynaptic alpha7nAChR. Acetylcholine 14-17 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 137-148 20387628-6 2009 Anti-CD40-induced B lymphocyte proliferation studied by [3H]thymidine incorporation was increased upon alpha7 nAChR inhibition with methyllicaconitine, choline or antibiotic gentamicin, as well as in the presence of the inhibitor of acetylcholine synthesis hemicholine-3. Acetylcholine 233-246 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 103-115 19230830-1 2009 The alpha7 nicotinic acetylcholine receptor (nAChR) plays an important role in cognitive processes and has generated recent interest as a potential drug target for treating neurodegenerative disorders such as Alzheimer"s disease (AD). Acetylcholine 21-34 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 45-50 21512307-1 2011 In small cell lung carcinoma (SCLC), acetylcholine (ACh) is synthesized and secreted, and it acts as an autocrine growth factor through activation of its receptors, muscarinic receptor (mAChR) and nicotinic receptor (nAChR). Acetylcholine 37-50 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 217-222 21512307-1 2011 In small cell lung carcinoma (SCLC), acetylcholine (ACh) is synthesized and secreted, and it acts as an autocrine growth factor through activation of its receptors, muscarinic receptor (mAChR) and nicotinic receptor (nAChR). Acetylcholine 52-55 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 217-222 20621062-2 2010 Moreover, the effects of ACh are modified by secreted ly-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), a positive allosteric modulator of alpha7 nAChR signaling. Acetylcholine 25-28 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 169-181 20203199-10 2010 These data indicate that striatal mAChRs, by inhibiting ACh release from cholinergic interneurons and thus modifying nAChR activity, offer variable control of DA release probability that promotes how DA release reflects activation of dopaminergic axons. Acetylcholine 35-38 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 117-122 14762152-4 2004 Agonist efficacy order for eliciting the axonal nAChR calcium response was cytisine approximately nicotine >> acetylcholine. Acetylcholine 116-129 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 48-53 19116908-2 2009 The vagus nerve may exert antiinflammatory actions via a specific effect of its principal neurotransmitter, acetylcholine, on the alpha7 subunit of nicotinic acetylcholine receptors (alpha7nAChR) on macrophages. Acetylcholine 108-121 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 183-194 17383684-7 2007 These results suggest that the lymphocytic cholinergic system is activated by ACh via mAChR- and nAChR-mediated pathways during antigen presentation between T cells and DCs or macrophages, leading to modulation of immune cell function. Acetylcholine 78-81 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 97-102 18337473-1 2008 Alpha4 and beta2 nicotinic cholinergic receptor (nAChR) subunits can assemble in heterologous expression systems as pentameric receptors with different subunit stoichiometries that exhibit differential sensitivity to activation by acetylcholine, yielding biphasic concentration-effect curves. Acetylcholine 231-244 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 49-54 18337473-2 2008 nAChR-mediated (86)Rb(+) efflux in mouse brain synaptosomes also displays biphasic acetylcholine (ACh) concentration-response curves. Acetylcholine 83-96 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 0-5 16569710-5 2006 In contrast, message with UTR expressed exclusively the high-sensitivity alpha4beta2 nAChR subform with an acetylcholine EC50 value of 2.2 microM. Acetylcholine 107-120 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 85-90 16772172-4 2006 Deleting alpha7 or beta2 subunits modified the spontaneous firing patterns, demonstrating their direct stimulation by endogenous acetylcholine. Acetylcholine 129-142 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 9-15 12941437-5 2003 Recently, a selective abnormality in the transduction of the acetylcholine signal at the level of the alpha 7 nicotinic receptor has been described in schizophrenia. Acetylcholine 61-74 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 102-128 12606407-2 2003 Recently, we reported the results of antagonist studies suggesting that a nicotinic acetylcholine receptor (nAChR) containing an alpha7 subunit (alpha7nAChR) plays a role in the human sperm AR initiated by recombinant human ZP3 or by acetylcholine (ACh). Acetylcholine 84-97 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 145-156 12606407-2 2003 Recently, we reported the results of antagonist studies suggesting that a nicotinic acetylcholine receptor (nAChR) containing an alpha7 subunit (alpha7nAChR) plays a role in the human sperm AR initiated by recombinant human ZP3 or by acetylcholine (ACh). Acetylcholine 109-112 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 145-156 12606407-5 2003 Because the only nAChR subunit known to bind all three antagonists is the alpha7, an alpha7nAChR appears to be involved in the mouse sperm AR initiated by mouse ZP or by ACh. Acetylcholine 18-21 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 85-96 12628457-6 2003 Taken together, these results suggest an important role for alpha7 nAChR in mediating plethoric effects of non-neuronal acetylcholine on cutaneous homeostasis. Acetylcholine 120-133 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 60-72 12671524-1 2003 Abnormalities of the transduction of the acetylcholine signal in the brain by the alpha(7) nicotinic receptor are thought to contribute substantially to a fundamental pathophysiologic mechanism in schizophrenia. Acetylcholine 41-54 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 82-109 11562442-14 2001 The association rates of both antagonists are comparable with or greater than the association rate for acetylcholine binding to nAChR. Acetylcholine 103-116 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 128-133 12391028-8 2002 Thus, this study demonstrates that ACh signaling through alpha7 nAChR channels controls late stages of keratinocyte development in the epidermis by regulating expression of the cell cycle progression, apoptosis, and terminal differentiation genes and that these effects are mediated, at least in part, by alterations in transmembrane Ca2+ influx. Acetylcholine 35-38 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 57-69 12270040-4 2002 The experimental data were interpreted by the addition of a transition from the desensitized state with two bound ACh molecules to a slow desensitized state to the well known circular kinetic scheme of activation and desensitization of nAChR channels. Acetylcholine 114-117 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 236-241 10064590-1 1999 We have examined neuroanatomical, biochemical and endocrine parameters and spatial learning in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) during ageing. Acetylcholine 143-156 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 167-172 10861798-4 2000 In order to test this hypothesis, we examined the ability of PCP to inhibit acetylcholine-induced currents from wild-type nAChR and nAChR in which amino acid substitutions were made in the 6", 8" and 10" positions of the M2 transmembrane segments of the receptor. Acetylcholine 76-89 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 122-127 11145999-0 2001 Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum. Acetylcholine 29-42 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 122-127 11098122-5 2000 Intact motoneurons responded to acetylcholine by generating a rapidly rising inward current, which was insensitive to methyllycaconitine, a selective antagonist of alpha7-containing nicotinic receptors, but was suppressed by dihydro-beta-erythroidine, a broad-spectrum antagonist. Acetylcholine 32-45 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 164-170 8730587-2 1996 Using the patch-clamp technique, we have found that mouse muscle nicotinic acetylcholine receptor (nAChR) channels can be activated by low concentrations of a monoclonal antibody (MoAb), referred to as WF6, which is directed against the acetylcholine (ACh) binding site. Acetylcholine 75-88 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 99-104 9576627-1 1998 Several subunits that commonly have been regarded as neuronal-type nicotinic acetylcholine receptor (nAChR) subtypes, have been found in the postjunctional endplate membrane of adult skeletal muscle fibres. Acetylcholine 77-90 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 101-106 9121692-5 1997 tauD varied from 10 ms to 100 ms with a mean value of 55.0 +/- 22.6 ms (n = 133) in response to pulses of 10(-4) M ACh for embryonic-like nAChR channels and from 2.6 ms to 8.9 ms with a mean value of 5.0 +/- 1.9 ms (n = 35) in response to pulses of 10(-2) M Glu for homomeric GluR6 receptor channels. Acetylcholine 115-118 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 138-143 8568931-4 1995 The biophysical properties of the spontaneous activity were similar to those of the embryonic form of the nAChR in the presence of acetylcholine (ACh). Acetylcholine 131-144 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 106-111 7478934-1 1995 The rate of desensitization of nicotinic acetylcholine (ACh) receptor (nAChR), an important characteristic of nAChR function, was studied in myotubes of the mouse C2C12 cell line at different times after fusion, by measuring the decay of ACh-evoked currents (IACh) under various patch-clamp configurations. Acetylcholine 56-59 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 71-76 7478934-1 1995 The rate of desensitization of nicotinic acetylcholine (ACh) receptor (nAChR), an important characteristic of nAChR function, was studied in myotubes of the mouse C2C12 cell line at different times after fusion, by measuring the decay of ACh-evoked currents (IACh) under various patch-clamp configurations. Acetylcholine 56-59 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 110-115 7554431-10 1995 Pb2+ blocks ACh-induced inward currents mediated by alpha 3 beta 4 nAChR. Acetylcholine 12-15 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 67-72 34864929-2 2021 This role is mediated by ACh activation of its nicotinic (nAChR) and muscarinic (mAChR) classes of receptors, which are both present on mPFC layer VI pyramidal neurons. Acetylcholine 25-28 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 58-63 8478989-7 1993 It is concluded that the regulation of ACh responses by 5HT results from a fast noncompetitive blocking action of nAChR-channels. Acetylcholine 39-42 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 114-119 2253264-14 1990 Finally, ADP reversed the phencyclidine-induced block of ACh currents in oocytes expressing muscle nAChR. Acetylcholine 57-60 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 99-104 34196664-2 2021 In the current study, we used doxycycline-inducible astrocyte-specific HIV Tat transgenic mice (iTat), a surrogate HAND model and determined effects of PNU-125096, a positive allosteric modulator of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) on Tat-induced behavioral impairments and neuropathologies. Acetylcholine 216-229 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 240-252 1578136-1 1992 The presence and structure of nicotinic acetylcholine receptor (nAChR) in the thymus has been a subject of interest for many years because of its possible role in the pathogenesis of the autoimmune disease myasthenia gravis. Acetylcholine 40-53 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 64-69 33815383-1 2021 Background: The alpha7 nicotinic acetylcholine receptor (Chrna7) plays an essential anti-inflammatory role in immune homeostasis and was recently found on mast cells (MC). Acetylcholine 33-46 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 57-63 33777911-1 2021 Background: It has been confirmed that the alpha7-nicotinic acetylcholine receptor (alpha7nAChR) is an important target for identifying vulnerable atherosclerotic plaques. Acetylcholine 60-73 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 84-95 34299169-2 2021 This study investigated changes in the expression levels of nicotinic and muscarinic acetylcholine receptors (nAChR and mAChR) in the lung during acute lung injury. Acetylcholine 85-98 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 110-115 34374537-1 2021 Enhancing neuronal alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) function can alleviate cognitive deficits. Acetylcholine 36-49 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 60-72 34434092-8 2021 Application of nAChR antagonists revealed that acetylcholine excites VIP neurons mainly via activation of alpha3beta4 * nAChRs, a nAChR subtype that is rare in the brain. Acetylcholine 47-60 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 15-20 34708522-4 2021 In the cerebral zone of APP/PS1 mice, the level of Abeta was increased and those of alpha7 nicotinic acetylcholine receptors (nAChR), phosphor-GSK3beta (ser9), beta-catenin and cyclin D1 (protein and/or mRNA levels) reduced. Acetylcholine 101-114 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 126-131 34434092-8 2021 Application of nAChR antagonists revealed that acetylcholine excites VIP neurons mainly via activation of alpha3beta4 * nAChRs, a nAChR subtype that is rare in the brain. Acetylcholine 47-60 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 130-135 34092296-7 2021 The results indicate that bufotenine and its derivatives are closely related to acetyl cholinesterase (AChE) or alpha4beta2 nicotinic acetylcholine receptor (nAChR). Acetylcholine 134-147 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 158-163 34386327-2 2021 In this study, we aimed to investigate the protective effect of VMY-2-95, the new selective antagonist of alpha4beta2 nicotinic acetylcholine receptor (nAChR) on corticosterone (CORT) injured mice and cellular models. Acetylcholine 128-141 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 152-157 35597124-2 2022 We hypothesized that vagus nerve mediates alpha 7 nicotinic acetylcholine receptor (alpha7nAChR) expression in monocytes, an essential regulator of cholinergic anti-inflammatory activity, and the spleen is essential site for this process. Acetylcholine 60-73 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 84-95 35576655-2 2022 Regulating the alpha7 nicotinic acetylcholine receptor (alpha7 nAchR)-mediated signaling may be a promising strategy to treat sepsis. Acetylcholine 32-45 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 56-68 35597124-6 2022 The effect of norepinephrine (NE), acetylcholine (ACh) and neuregulin-1 (NRG-1) on alpha7nAChR expression was detected by real-time PCR. Acetylcholine 35-48 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 83-94 35597124-6 2022 The effect of norepinephrine (NE), acetylcholine (ACh) and neuregulin-1 (NRG-1) on alpha7nAChR expression was detected by real-time PCR. Acetylcholine 50-53 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 83-94 35397284-2 2022 In a previous study, SIN acted on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) to inhibit inflammatory responses in macrophages, which indicates a new anti-inflammatory mechanism of SIN. Acetylcholine 51-64 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 75-86 35323499-1 2022 The alpha7 nicotinic acetylcholine receptor (nAChR) is widely distributed in the central and peripheral nervous systems and is closely related to a variety of nervous system diseases and inflammatory responses. Acetylcholine 21-34 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 45-50 35578169-4 2022 Here we hypothesized that famotidine activates the inflammatory reflex, a brain-integrated vagus nerve mechanism which inhibits inflammation via alpha 7 nicotinic acetylcholine receptor (alpha7nAChR) signal transduction, to prevent cytokine storm. Acetylcholine 163-176 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 187-198 35413868-2 2022 We hypothesize that alpha7 nicotinic acetylcholine receptor (alpha7nAChR) plays an important role in regulation of this process. Acetylcholine 37-50 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 61-72 35351863-2 2022 Although the cholinergic anti-inflammatory pathway, which is mediated by the alpha-7 nicotinic acetylcholine receptor (alpha7nAChR), is critical for controlling multiple types of inflammation, its expression pattern and pathogenesis function in psoriatic lesioned skin tissue are unknown. Acetylcholine 95-108 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 119-130 35441176-5 2022 Here we hypothesized that famotidine activates the inflammatory reflex, a brain-integrated vagus nerve mechanism which inhibits inflammation via alpha 7 nicotinic acetylcholine receptor ( alpha7nAChR ) signal transduction, to prevent cytokine storm. Acetylcholine 163-176 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 188-199 35222419-10 2022 Intriguingly, our results showed that EA stimulation at the Zusanli (ST36) acupoint activated alpha7 nicotinic acetylcholine receptor (alpha7nAchR) in lung tissue mainly through the sciatic nerve and cervical vagus nerve, thus exerting anti-ferroptosis and pulmonary protective effects. Acetylcholine 111-124 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 135-146 35129858-1 2022 The non-classical function of acetylcholine (ACh) has been reported in neuroinflammation that represents the modulating factor in immune responses via activation of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR), i.e., a cholinergic anti-inflammatory pathway (CAP). Acetylcholine 30-43 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 206-218 35129858-1 2022 The non-classical function of acetylcholine (ACh) has been reported in neuroinflammation that represents the modulating factor in immune responses via activation of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR), i.e., a cholinergic anti-inflammatory pathway (CAP). Acetylcholine 45-48 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 206-218 35129858-1 2022 The non-classical function of acetylcholine (ACh) has been reported in neuroinflammation that represents the modulating factor in immune responses via activation of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR), i.e., a cholinergic anti-inflammatory pathway (CAP). Acetylcholine 182-195 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 206-218 35129858-7 2022 Moreover, ACh or alpha7 nAChR agonist suppressed the LPS-induced production of pro-inflammatory cytokines, as well as the phagocytosis of microglia, by activating alpha7 nAChR and followed by the regulation of NF-kappaB and CREB signaling. Acetylcholine 10-13 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 163-175 35217818-2 2022 Our previous studies found that activating alpha7 nicotinic acetylcholine receptor (alpha7nAChR) had a protective effect on vascular injury. Acetylcholine 60-73 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 84-95 35063770-3 2022 Herein, we show that AV treatment had antidepressant-like effect in physiological conditions and antidepressant effect in depressive state which depended on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) expression in the ventral hippocampus (vHPC), but not alpha4beta2 nicotinic acetylcholine receptor (alpha4beta2nAchR) expression in vHPC, nor the alpha7nAChR and alpha4beta2nAchR expression in dorsal hippocampus (dHPC). Acetylcholine 174-187 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 198-209 35063770-3 2022 Herein, we show that AV treatment had antidepressant-like effect in physiological conditions and antidepressant effect in depressive state which depended on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) expression in the ventral hippocampus (vHPC), but not alpha4beta2 nicotinic acetylcholine receptor (alpha4beta2nAchR) expression in vHPC, nor the alpha7nAChR and alpha4beta2nAchR expression in dorsal hippocampus (dHPC). Acetylcholine 174-187 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 357-368 35063770-3 2022 Herein, we show that AV treatment had antidepressant-like effect in physiological conditions and antidepressant effect in depressive state which depended on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) expression in the ventral hippocampus (vHPC), but not alpha4beta2 nicotinic acetylcholine receptor (alpha4beta2nAchR) expression in vHPC, nor the alpha7nAChR and alpha4beta2nAchR expression in dorsal hippocampus (dHPC). Acetylcholine 287-300 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 198-209 34789702-2 2022 The alpha7 nicotinic acetylcholine receptor (alpha7nAchR) expressed on immune cells regulates the vagal anti-inflammatory pathway that prevents an overwhelming SIRS response to injury. Acetylcholine 21-34 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 45-56 35095424-3 2021 Here to test this possibility, we studied vestibular function in mice lacking a functional alpha9 subunit of the nicotinic acetylcholine receptor (nAChR) gene family, which mediates efferent activation of the vestibular periphery. Acetylcholine 123-136 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 147-152 35021080-3 2022 Remarkably, in mice lacking the beta2 subunit of neuronal nicotinic acetylcholine receptors (beta2-nAChR-KO), which exhibit drastically reduced cholinergic retinal waves in the first postnatal week, selectivity to horizontal motion is absent while selectivity to vertical motion remains. Acetylcholine 68-81 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 99-104 34980874-1 2022 BACKGROUND To reveal the mechanism underlying the effect of alpha7 nicotinic acetylcholine receptor (nAChR) on neurodegeneration in Alzheimer disease (AD), the influence of the receptor on recognition in APP/PS1 mice was evaluated by using its selective agonist (PNU-282987). Acetylcholine 77-90 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 101-106