PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12364493-8 2002 The results suggest that mGluR1 and mGluR5 are activated synaptically during prolonged epileptiform discharges induced by bicuculline and 4-AP. Bicuculline 122-133 glutamate receptor, ionotropic, kainate 1 Mus musculus 36-42 23274309-4 2013 Here, we show that treating rat hippocampal cultures with bicuculline and 4-aminopyridine (Bic+4-AP) evoked epileptiform activity and synchronized Ca(2+) spiking, measured with whole cell current-clamp and fura-2-based digital imaging; Bic+4-AP increased H1a mRNA through the activation of metabotropic glutamate receptor 5 (mGluR5). Bicuculline 58-69 glutamate receptor, ionotropic, kainate 1 Mus musculus 325-331 22973007-5 2012 We show here that MeCP2 phosphorylation is specifically required for bicuculline-induced synaptic scaling down in mouse hippocampal neurons and this phenotype is mediated by mGluR5 (metabotropic glutamate receptor 5). Bicuculline 69-80 glutamate receptor, ionotropic, kainate 1 Mus musculus 174-180