PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26119958-7	2015	Using p53(-/-) and p53(+/+) HCT-116 cells, we confirmed that p53/p21 was the main pathway that contributed to the G2/M cell cycle arrest by 6-shogaol.	shogaol	140-149	tumor protein p53	Homo sapiens	6-9	
17263498-0	2007	6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism.	shogaol	0-9	tumor protein p53	Homo sapiens	80-83	
34644781-9	2021	RESULTS: In our results, 6-shogaol not only suppressed proliferation and anchorage-independent cell growth in OSCC cells, but also induced apoptosis by regulating the apoptosis-associated factors such as p53, Bax, Bcl-2, and cleaved caspase-3.	shogaol	25-34	tumor protein p53	Homo sapiens	204-207	
30483736-0	2019	Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS.	shogaol	33-42	tumor protein p53	Homo sapiens	110-113	
30483736-3	2019	The current study identified a potential pathway by revealing that TRAIL and 6-sho or chloroquine acted together to trigger reactive oxygen species (ROS) production, to upregulate tumor-suppressor protein 53 (p53) expression and to change the mitochondrial transmembrane potential (MTP).	shogaol	77-82	tumor protein p53	Homo sapiens	209-212	
30483736-6	2019	In conclusion, attenuation of 6-sho-induced autophagy flux sensitized cells to TRAIL-induced apoptosis via p53 and ROS, suggesting that the administration of TRAIL in combination with 6-sho may be a suitable therapeutic method for the treatment of TRAIL-resistant Huh7 liver cells.	shogaol	30-35	tumor protein p53	Homo sapiens	107-110	
26119958-7	2015	Using p53(-/-) and p53(+/+) HCT-116 cells, we confirmed that p53/p21 was the main pathway that contributed to the G2/M cell cycle arrest by 6-shogaol.	shogaol	140-149	tumor protein p53	Homo sapiens	19-22	
26119958-7	2015	Using p53(-/-) and p53(+/+) HCT-116 cells, we confirmed that p53/p21 was the main pathway that contributed to the G2/M cell cycle arrest by 6-shogaol.	shogaol	140-149	tumor protein p53	Homo sapiens	19-22	
24446736-0	2014	Induction of lung cancer cell apoptosis through a p53 pathway by [6]-shogaol and its cysteine-conjugated metabolite M2.	shogaol	65-76	tumor protein p53	Homo sapiens	50-53	
26119958-0	2015	Anti-Colon Cancer Effects of 6-Shogaol Through G2/M Cell Cycle Arrest by p53/p21-cdc2/cdc25A Crosstalk.	shogaol	29-38	tumor protein p53	Homo sapiens	73-76