PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27286707-0	2016	6-Shogaol has anti-amyloidogenic activity and ameliorates Alzheimer"s disease via CysLT1R-mediated inhibition of cathepsin B.	shogaol	0-9	cysteinyl leukotriene receptor 1	Mus musculus	82-89	
27286707-3	2016	Specifically, we investigated the effects of 6-shogaol on the cysteinyl leukotriene 1 receptor (CysLT1R), a major factor in AD pathogenesis.	shogaol	45-54	cysteinyl leukotriene receptor 1	Mus musculus	62-94	
27286707-3	2016	Specifically, we investigated the effects of 6-shogaol on the cysteinyl leukotriene 1 receptor (CysLT1R), a major factor in AD pathogenesis.	shogaol	45-54	cysteinyl leukotriene receptor 1	Mus musculus	96-103	
27286707-5	2016	We used in vitro and in vivo models to determine whether 6-shogaol inhibits CysLT1R/cathepsin B in an amyloid-beta (Abeta; 1-42)-induced model of neurotoxicity.	shogaol	57-66	cysteinyl leukotriene receptor 1	Mus musculus	76-83	
27286707-7	2016	In contrast, we found that 6-shogaol-mediated inhibition of CysLT1R downregulates cathepsin B in both in vitro and in vivo models.	shogaol	27-36	cysteinyl leukotriene receptor 1	Mus musculus	60-67	
27286707-8	2016	Furthermore, we found that 6-shogaol-mediated inhibition of CysLT1R/cathepsin B reduces Abeta deposition in the brain and ameliorates behavioral deficits in APPSw/PS1-dE9 Tg mice.	shogaol	27-36	cysteinyl leukotriene receptor 1	Mus musculus	60-67	
27286707-9	2016	Our results indicate that 6-shogaol is a CysLT1R/cathepsin B inhibitor and is a novel potential therapeutic agent for the treatment of various neurodegenerative diseases, including AD.	shogaol	26-35	cysteinyl leukotriene receptor 1	Mus musculus	41-48	
27346834-10	2016	Mechanistic studies revealed that 6-shogaol inhibits the cysteinyl leukotriene 1 receptor (CysLT1R) and mitogen-activated protein kinase (MAPK) signaling proteins, thus providing a potential pharmacological mechanism for our observations.	shogaol	34-43	cysteinyl leukotriene receptor 1	Mus musculus	57-89	
27346834-10	2016	Mechanistic studies revealed that 6-shogaol inhibits the cysteinyl leukotriene 1 receptor (CysLT1R) and mitogen-activated protein kinase (MAPK) signaling proteins, thus providing a potential pharmacological mechanism for our observations.	shogaol	34-43	cysteinyl leukotriene receptor 1	Mus musculus	91-98