PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24215632-0	2013	6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2alpha.	shogaol	0-9	eukaryotic translation initiation factor 2A	Homo sapiens	109-118	
24215632-8	2013	The docking results suggested that 6-shogaol might bind well to eIF2alpha at Ser51 of the N-terminal domain.	shogaol	35-44	eukaryotic translation initiation factor 2A	Homo sapiens	64-73	
24215632-9	2013	Immunoblotting data indicated that 6-shogaol induced apoptosis through a process involving dephosphorylation of eIF2alpha and caspase activation-dependent cleavage of eIF2alpha.	shogaol	35-44	eukaryotic translation initiation factor 2A	Homo sapiens	112-121	
24215632-9	2013	Immunoblotting data indicated that 6-shogaol induced apoptosis through a process involving dephosphorylation of eIF2alpha and caspase activation-dependent cleavage of eIF2alpha.	shogaol	35-44	eukaryotic translation initiation factor 2A	Homo sapiens	167-176	
22768104-11	2012	Altogether our results indicate that the PERK/eIF2alpha pathway plays an important role in 6-shogaol-mediated ER stress and apoptosis in SMMC-7721 cells in vitro and in vivo.	shogaol	91-100	eukaryotic translation initiation factor 2A	Homo sapiens	46-55	
22768104-4	2012	6-shogaol affected the ER stress signaling by regulating unfolded protein response (UPR) sensor PERK and its downstream target eIF2alpha.	shogaol	0-9	eukaryotic translation initiation factor 2A	Homo sapiens	127-136	
22768104-6	2012	In prolonged ER stress, 6-shogaol inhibited the phosphorylation of eIF2alpha and triggered apoptosis in SMMC-7721 cells.	shogaol	24-33	eukaryotic translation initiation factor 2A	Homo sapiens	67-76	
22768104-8	2012	However, combined treatment with 6-shogaol and salubrinal resulted in significantly increase of apoptosis and dephosphorylation of eIF2alpha.	shogaol	33-42	eukaryotic translation initiation factor 2A	Homo sapiens	131-140	
22768104-9	2012	Overexpression of eIF2alpha prevented 6-shogaol-mediated apoptosis in SMMC-7721 cells, whereas inhibition of eIF2alpha by small interfering RNA markedly enhanced 6-shogaol-mediated cell death.	shogaol	38-47	eukaryotic translation initiation factor 2A	Homo sapiens	18-27	
22768104-9	2012	Overexpression of eIF2alpha prevented 6-shogaol-mediated apoptosis in SMMC-7721 cells, whereas inhibition of eIF2alpha by small interfering RNA markedly enhanced 6-shogaol-mediated cell death.	shogaol	162-171	eukaryotic translation initiation factor 2A	Homo sapiens	109-118	
32998376-8	2020	Moreover, 6-Shogaol also upregulated the expression and phosphorylation of GRP-78, eIF-2alpha, ATF4, and CHOP, known ER stress markers, in SW872 cells, illustrating the induction of ER stress.	shogaol	10-19	eukaryotic translation initiation factor 2A	Homo sapiens	83-93