PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21342125-6 2011 Several exogenous AhR ligands, such as PAHs, polychlorinated biphenyls and halogenated dioxins, can be found in the constituents of numerous commercial products, including insulators and flame retardants, or as products of combustion processes, including chimney soot, charbroiled foods and cigarette smoke, or as the product of waste incineration. Polychlorinated Biphenyls 45-70 aryl hydrocarbon receptor Homo sapiens 18-21 22664347-2 2012 Whilst coplanar PCBs elicit their toxic effects through agonism of the aryl hydrocarbon receptor; however, non-coplanar PCBs are not ligands for AhR, but may be ligands for members of the nuclear receptor family of proteins. Polychlorinated Biphenyls 16-20 aryl hydrocarbon receptor Homo sapiens 71-96 22521609-0 2012 EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes. Polychlorinated Biphenyls 40-43 aryl hydrocarbon receptor Homo sapiens 91-94 22119921-8 2012 As was similarly observed for polychlorinated biphenyls (PCBs), the preferential bromination at para- and meta (particularly 3,3"-)-sites was confirmed as a key determinant to improve the AhR binding affinity and the toxicity of PBDEs. Polychlorinated Biphenyls 30-55 aryl hydrocarbon receptor Homo sapiens 188-191 22119921-8 2012 As was similarly observed for polychlorinated biphenyls (PCBs), the preferential bromination at para- and meta (particularly 3,3"-)-sites was confirmed as a key determinant to improve the AhR binding affinity and the toxicity of PBDEs. Polychlorinated Biphenyls 57-61 aryl hydrocarbon receptor Homo sapiens 188-191 21571617-2 2011 Humans genetically have > 60-fold differences in hepatic cytochrome P450 1A2 (CYP1A2)-uninduced basal levels and > 12-fold variability in aryl hydrocarbon receptor (AHR)affinity; because CYP1A2 is known to sequester coplanar PCBs and because AHR ligands include coplanar PCBs, both genotypes can affect PCB response. Polychlorinated Biphenyls 231-235 aryl hydrocarbon receptor Homo sapiens 144-169 21571617-2 2011 Humans genetically have > 60-fold differences in hepatic cytochrome P450 1A2 (CYP1A2)-uninduced basal levels and > 12-fold variability in aryl hydrocarbon receptor (AHR)affinity; because CYP1A2 is known to sequester coplanar PCBs and because AHR ligands include coplanar PCBs, both genotypes can affect PCB response. Polychlorinated Biphenyls 277-281 aryl hydrocarbon receptor Homo sapiens 144-169 21357386-1 2011 The toxic equivalency concept used for the risk assessment of polychlorinated biphenyls (PCBs) is based on the aryl hydrocarbon receptor (AhR)-mediated toxicity of coplanar dioxin-like (DL) PCBs. Polychlorinated Biphenyls 62-87 aryl hydrocarbon receptor Homo sapiens 111-136 21357386-1 2011 The toxic equivalency concept used for the risk assessment of polychlorinated biphenyls (PCBs) is based on the aryl hydrocarbon receptor (AhR)-mediated toxicity of coplanar dioxin-like (DL) PCBs. Polychlorinated Biphenyls 62-87 aryl hydrocarbon receptor Homo sapiens 138-141 21357386-1 2011 The toxic equivalency concept used for the risk assessment of polychlorinated biphenyls (PCBs) is based on the aryl hydrocarbon receptor (AhR)-mediated toxicity of coplanar dioxin-like (DL) PCBs. Polychlorinated Biphenyls 89-93 aryl hydrocarbon receptor Homo sapiens 111-136 21357386-1 2011 The toxic equivalency concept used for the risk assessment of polychlorinated biphenyls (PCBs) is based on the aryl hydrocarbon receptor (AhR)-mediated toxicity of coplanar dioxin-like (DL) PCBs. Polychlorinated Biphenyls 89-93 aryl hydrocarbon receptor Homo sapiens 138-141 21357386-11 2011 Due to small differences in relative potency among congeners, the highly abundant indicator PCBs 28, 52, 101, 118, 138, 153, and 180 also contributed most to the antiandrogenic, (anti)estrogenic, antithyroidal, tumor-promoting, and neurotoxic potencies calculated for PCB mixtures reported in human samples, whereas the most potent AhR-activating DL-PCB-126 contributed at maximum 0.2% to any of these calculated potencies. Polychlorinated Biphenyls 92-96 aryl hydrocarbon receptor Homo sapiens 332-335 22004969-1 2011 Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) binding with the aryl hydrocarbon receptor (AhR) have been correlated with many toxic responses. Polychlorinated Biphenyls 0-25 aryl hydrocarbon receptor Homo sapiens 103-128 22004969-1 2011 Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) binding with the aryl hydrocarbon receptor (AhR) have been correlated with many toxic responses. Polychlorinated Biphenyls 0-25 aryl hydrocarbon receptor Homo sapiens 130-133 22004969-1 2011 Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) binding with the aryl hydrocarbon receptor (AhR) have been correlated with many toxic responses. Polychlorinated Biphenyls 27-31 aryl hydrocarbon receptor Homo sapiens 103-128 22004969-1 2011 Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) binding with the aryl hydrocarbon receptor (AhR) have been correlated with many toxic responses. Polychlorinated Biphenyls 27-31 aryl hydrocarbon receptor Homo sapiens 130-133 22004969-3 2011 In this study, an integrated molecular docking and 3D-QSAR approach was employed to investigate the binding interactions between PCBs, PCDDs, PCDFs and AhR. Polychlorinated Biphenyls 129-133 aryl hydrocarbon receptor Homo sapiens 152-155 20106901-1 2010 The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, which is activated by a large group of environmental pollutants including polycyclic aromatic hydrocarbons, dioxins and planar polychlorinated biphenyls. Polychlorinated Biphenyls 207-232 aryl hydrocarbon receptor Homo sapiens 4-29 21348526-7 2011 Additionally, for one sample, high AhR-mediated activities were determined in one fraction characterized by PCDD/Fs, PCBs, and PCNs. Polychlorinated Biphenyls 117-121 aryl hydrocarbon receptor Homo sapiens 35-38 20961953-0 2011 In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Polychlorinated Biphenyls 58-83 aryl hydrocarbon receptor Homo sapiens 130-133 20106901-1 2010 The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, which is activated by a large group of environmental pollutants including polycyclic aromatic hydrocarbons, dioxins and planar polychlorinated biphenyls. Polychlorinated Biphenyls 207-232 aryl hydrocarbon receptor Homo sapiens 31-34 17912254-4 2008 These order of magnitude greater IEQs compared to the TEQs for dioxins, furans, and certain PCBs suggests that human blood contains a relatively high level of AHR agonists able to activate the CYP1A1 dioxin response element (DRE)-linked reporter gene bioassay and that this AHR activity is not accounted for by PCDDs/Fs and dioxin-like PCBs based on standard HR-GC/MS and TEF analysis. Polychlorinated Biphenyls 336-340 aryl hydrocarbon receptor Homo sapiens 159-162 20435334-7 2010 These results suggest that AhR-mediated transcriptional activity of Inuit plasma extracts is linked to their organochlorine body burden, most likely that of dioxin-like PCBs, polychlorinated dibenzo-p-dioxins and polychlorodibenzofurans. Polychlorinated Biphenyls 169-173 aryl hydrocarbon receptor Homo sapiens 27-30 19692669-2 2009 This study employed toxicogenomic technology to reveal species differences in response to two prototypical aryl hydrocarbon receptor (AHR) agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin and the polychlorinated biphenyl (PCB) congener PCB 126. Polychlorinated Biphenyls 192-216 aryl hydrocarbon receptor Homo sapiens 134-137 19692669-2 2009 This study employed toxicogenomic technology to reveal species differences in response to two prototypical aryl hydrocarbon receptor (AHR) agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin and the polychlorinated biphenyl (PCB) congener PCB 126. Polychlorinated Biphenyls 218-221 aryl hydrocarbon receptor Homo sapiens 134-137 19692669-2 2009 This study employed toxicogenomic technology to reveal species differences in response to two prototypical aryl hydrocarbon receptor (AHR) agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin and the polychlorinated biphenyl (PCB) congener PCB 126. Polychlorinated Biphenyls 232-235 aryl hydrocarbon receptor Homo sapiens 134-137 18762178-1 2008 Binding and activation of the aryl hydrocarbon receptor (AhR) is thought to be an essential step in the toxicity of the environmental pollutants dioxins and dioxin-like PCBs. Polychlorinated Biphenyls 169-173 aryl hydrocarbon receptor Homo sapiens 30-55 18762178-1 2008 Binding and activation of the aryl hydrocarbon receptor (AhR) is thought to be an essential step in the toxicity of the environmental pollutants dioxins and dioxin-like PCBs. Polychlorinated Biphenyls 169-173 aryl hydrocarbon receptor Homo sapiens 57-60 20152453-1 2010 Polychlorodibenzo-p-dioxins, polychorodibenzofurans and "dioxin-like" polychlorinated biphenyls are widespread persistent organic pollutants sharing a similar toxicological pathway mediated by the aryl-hydrocarbon receptor (AhR). Polychlorinated Biphenyls 70-95 aryl hydrocarbon receptor Homo sapiens 197-222 20152453-1 2010 Polychlorodibenzo-p-dioxins, polychorodibenzofurans and "dioxin-like" polychlorinated biphenyls are widespread persistent organic pollutants sharing a similar toxicological pathway mediated by the aryl-hydrocarbon receptor (AhR). Polychlorinated Biphenyls 70-95 aryl hydrocarbon receptor Homo sapiens 224-227 19327395-1 2009 The toxicities of polychlorinated biphenyls (PCBs) are thought to be mediated mainly by the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 18-43 aryl hydrocarbon receptor Homo sapiens 119-122 19327395-1 2009 The toxicities of polychlorinated biphenyls (PCBs) are thought to be mediated mainly by the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 45-49 aryl hydrocarbon receptor Homo sapiens 119-122 19327395-2 2009 However, little is known about changes to AhR-mediated effects caused by metabolic conversion of PCBs. Polychlorinated Biphenyls 97-101 aryl hydrocarbon receptor Homo sapiens 42-45 19327395-3 2009 To investigate whether hydroxylation affects the affinity of PCBs for the AhR, we measured the AhR agonistic activity of mono-hydroxylated PCBs (mono-OH-PCBs) and their non-hydroxylated analogs (PCBs) using yeast cells transduced with the human AhR and its response pathway. Polychlorinated Biphenyls 61-65 aryl hydrocarbon receptor Homo sapiens 74-77 19327395-3 2009 To investigate whether hydroxylation affects the affinity of PCBs for the AhR, we measured the AhR agonistic activity of mono-hydroxylated PCBs (mono-OH-PCBs) and their non-hydroxylated analogs (PCBs) using yeast cells transduced with the human AhR and its response pathway. Polychlorinated Biphenyls 139-143 aryl hydrocarbon receptor Homo sapiens 95-98 19327395-3 2009 To investigate whether hydroxylation affects the affinity of PCBs for the AhR, we measured the AhR agonistic activity of mono-hydroxylated PCBs (mono-OH-PCBs) and their non-hydroxylated analogs (PCBs) using yeast cells transduced with the human AhR and its response pathway. Polychlorinated Biphenyls 139-143 aryl hydrocarbon receptor Homo sapiens 95-98 18786521-4 2008 We focused on the role of caveolae and their major protein component, caveolin-1 (Cav-1), on aryl hydrocarbon receptor (AhR)-mediated induction of cytochrome P450 1A1 (CYP1A1) by coplanar PCBs. Polychlorinated Biphenyls 188-192 aryl hydrocarbon receptor Homo sapiens 93-118 18786521-4 2008 We focused on the role of caveolae and their major protein component, caveolin-1 (Cav-1), on aryl hydrocarbon receptor (AhR)-mediated induction of cytochrome P450 1A1 (CYP1A1) by coplanar PCBs. Polychlorinated Biphenyls 188-192 aryl hydrocarbon receptor Homo sapiens 120-123 17912254-4 2008 These order of magnitude greater IEQs compared to the TEQs for dioxins, furans, and certain PCBs suggests that human blood contains a relatively high level of AHR agonists able to activate the CYP1A1 dioxin response element (DRE)-linked reporter gene bioassay and that this AHR activity is not accounted for by PCDDs/Fs and dioxin-like PCBs based on standard HR-GC/MS and TEF analysis. Polychlorinated Biphenyls 92-96 aryl hydrocarbon receptor Homo sapiens 159-162 18025053-3 2007 The mRNA levels of eNOS, aryl hydrocarbon receptor (AhR) and cytochrome P450 (CYP) 1A1 in cells treated with 5 microM PCBs for 24 hours were analysed by real-time RT-PCR. Polychlorinated Biphenyls 118-122 aryl hydrocarbon receptor Homo sapiens 25-50 18484306-1 2008 The aryl hydrocarbon receptor (AhR) receives much attention for its role in the toxicity of dioxins and dioxin-like polychlorinated biphenyls. Polychlorinated Biphenyls 116-141 aryl hydrocarbon receptor Homo sapiens 31-34 17973563-5 2008 The assay was combined with congener-specific instrumental analyses and fractionation to quantify PCN contributions to total AhR-mediated activity relative to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs). Polychlorinated Biphenyls 225-250 aryl hydrocarbon receptor Homo sapiens 125-128 17973563-5 2008 The assay was combined with congener-specific instrumental analyses and fractionation to quantify PCN contributions to total AhR-mediated activity relative to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs). Polychlorinated Biphenyls 252-256 aryl hydrocarbon receptor Homo sapiens 125-128 17660003-12 2008 CONCLUSIONS: The hypothalamic-pituitary-gonadal axis of newborn babies is influenced by prenatal exposure to PCDD/Fs and PCBs in a manner suggestive of AhR-mediation. Polychlorinated Biphenyls 121-125 aryl hydrocarbon receptor Homo sapiens 152-155 18350874-9 2008 Under these conditions, a quantitative dose-effect relationship between TEQ(PCB) and EROD activity could be evaluated, suggesting that the observed AhR effect was mainly caused by PCBs. Polychlorinated Biphenyls 180-184 aryl hydrocarbon receptor Homo sapiens 148-151 18484306-1 2008 The aryl hydrocarbon receptor (AhR) receives much attention for its role in the toxicity of dioxins and dioxin-like polychlorinated biphenyls. Polychlorinated Biphenyls 116-141 aryl hydrocarbon receptor Homo sapiens 4-29 18025053-3 2007 The mRNA levels of eNOS, aryl hydrocarbon receptor (AhR) and cytochrome P450 (CYP) 1A1 in cells treated with 5 microM PCBs for 24 hours were analysed by real-time RT-PCR. Polychlorinated Biphenyls 118-122 aryl hydrocarbon receptor Homo sapiens 52-55 18025053-7 2007 These results suggest that the eNOS mRNA expression increases due to the action of PCBs related to both AhR and ERs in HUVECs, and that maternal PCB exposure could influence fetal circulation. Polychlorinated Biphenyls 83-87 aryl hydrocarbon receptor Homo sapiens 104-107 21959539-0 2007 Fractionation and Determination of Ah Receptor (AhR) Agonists in Organic Waste After Anaerobic Biodegradation and in Batch Experiments with PCB and decaBDE (8 pp). Polychlorinated Biphenyls 140-143 aryl hydrocarbon receptor Homo sapiens 35-46 17512696-8 2007 Exposure of H295R to PCBs with different AhR activation abilities also varied CYP19 and CYP1A1 expression in dissimilar patterns, although the CYP19 mRNA levels were in line with the AhR activation abilities of the congeners. Polychlorinated Biphenyls 21-25 aryl hydrocarbon receptor Homo sapiens 41-44 17512696-8 2007 Exposure of H295R to PCBs with different AhR activation abilities also varied CYP19 and CYP1A1 expression in dissimilar patterns, although the CYP19 mRNA levels were in line with the AhR activation abilities of the congeners. Polychlorinated Biphenyls 21-25 aryl hydrocarbon receptor Homo sapiens 183-186 21959539-0 2007 Fractionation and Determination of Ah Receptor (AhR) Agonists in Organic Waste After Anaerobic Biodegradation and in Batch Experiments with PCB and decaBDE (8 pp). Polychlorinated Biphenyls 140-143 aryl hydrocarbon receptor Homo sapiens 48-51 16934159-1 2006 BACKGROUND: Aroclor 1254 is a well-known hepatotoxin and consists of a complex mixture of polychlorinated biphenyls (PCBs), some of which have the ability to activate the aryl hydrocarbon receptor (AhR) and other transcription factors (TFs). Polychlorinated Biphenyls 90-115 aryl hydrocarbon receptor Homo sapiens 171-196 16934159-1 2006 BACKGROUND: Aroclor 1254 is a well-known hepatotoxin and consists of a complex mixture of polychlorinated biphenyls (PCBs), some of which have the ability to activate the aryl hydrocarbon receptor (AhR) and other transcription factors (TFs). Polychlorinated Biphenyls 90-115 aryl hydrocarbon receptor Homo sapiens 198-201 16934159-1 2006 BACKGROUND: Aroclor 1254 is a well-known hepatotoxin and consists of a complex mixture of polychlorinated biphenyls (PCBs), some of which have the ability to activate the aryl hydrocarbon receptor (AhR) and other transcription factors (TFs). Polychlorinated Biphenyls 117-121 aryl hydrocarbon receptor Homo sapiens 171-196 16934159-1 2006 BACKGROUND: Aroclor 1254 is a well-known hepatotoxin and consists of a complex mixture of polychlorinated biphenyls (PCBs), some of which have the ability to activate the aryl hydrocarbon receptor (AhR) and other transcription factors (TFs). Polychlorinated Biphenyls 117-121 aryl hydrocarbon receptor Homo sapiens 198-201 16781112-8 2006 Finally, since coplanar PCBs, induce gene expression via a ligand-dependent transactivating factor, the aryl hydrocarbon receptor, this signalling pathway is also reviewed with respect to understanding the toxic mechanisms of these compounds. Polychlorinated Biphenyls 24-28 aryl hydrocarbon receptor Homo sapiens 104-129 16725033-1 2006 BACKGROUND: Persistent organic pollutants (POPs) such as polychlorinated dibenzo-p-dioxins/furans, polychlorinated biphenyls (PCBs) and organochlorine pesticides can cause a series of adverse effects on e.g. reproduction in animals and humans, many of which involve the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 99-124 aryl hydrocarbon receptor Homo sapiens 270-295 16601081-2 2006 Structural similarities of PBDEs with other polyhalogenated aromatic hydrocarbons that show affinity for the aryl hydrocarbon receptor (AhR), such as some polychlorinated biphenyls, raised concerns about their possible dioxin-like properties. Polychlorinated Biphenyls 155-180 aryl hydrocarbon receptor Homo sapiens 109-134 16601081-2 2006 Structural similarities of PBDEs with other polyhalogenated aromatic hydrocarbons that show affinity for the aryl hydrocarbon receptor (AhR), such as some polychlorinated biphenyls, raised concerns about their possible dioxin-like properties. Polychlorinated Biphenyls 155-180 aryl hydrocarbon receptor Homo sapiens 136-139 16725033-1 2006 BACKGROUND: Persistent organic pollutants (POPs) such as polychlorinated dibenzo-p-dioxins/furans, polychlorinated biphenyls (PCBs) and organochlorine pesticides can cause a series of adverse effects on e.g. reproduction in animals and humans, many of which involve the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 99-124 aryl hydrocarbon receptor Homo sapiens 297-300 15681594-1 2005 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates immunosuppression induced by a variety of ubiquitous environmental pollutants, including polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and dioxins. Polychlorinated Biphenyls 216-241 aryl hydrocarbon receptor Homo sapiens 4-29 16704060-1 2006 Toxic effects of many persistent organic pollutants (e.g., polychlorinated biphenyls or polychlorinated dibenzo-p-dioxins and furans) are mediated via the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 59-84 aryl hydrocarbon receptor Homo sapiens 155-180 16704060-1 2006 Toxic effects of many persistent organic pollutants (e.g., polychlorinated biphenyls or polychlorinated dibenzo-p-dioxins and furans) are mediated via the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 59-84 aryl hydrocarbon receptor Homo sapiens 182-185 16291828-3 2006 In the present study, we aimed to investigate the effects of TCDD (1 and 10 nM) and dioxin-like PCB 126 (306 nM) on the AhR signaling pathway and on the gene expression profiles of key factors involved in thyroid function, including thyroglobulin (TG), thyroid peroxidase (TPO), the sodium iodide symporter (NIS), TSH receptor (TSHR), and cathepsins (Cat B and L), using a primary porcine thyrocyte culture as the experimental model. Polychlorinated Biphenyls 96-99 aryl hydrocarbon receptor Homo sapiens 120-123 16291828-6 2006 However, treatment with TCDD and PCB 126 induced an AhR signaling response, as indicated by the expression of the AhR-target gene cytochrome P-450 1A1 (CYP1A1). Polychlorinated Biphenyls 33-36 aryl hydrocarbon receptor Homo sapiens 52-55 16291828-6 2006 However, treatment with TCDD and PCB 126 induced an AhR signaling response, as indicated by the expression of the AhR-target gene cytochrome P-450 1A1 (CYP1A1). Polychlorinated Biphenyls 33-36 aryl hydrocarbon receptor Homo sapiens 114-117 16411661-9 2006 A practical application of the receptor-based screen developed here with RyR1 is that it provides a quantitative SAR that may be useful in predicting biological activity and risk of mixtures containing noncoplanar PCB congeners that have low or a lack of aryl hydrocarbon receptor activity. Polychlorinated Biphenyls 214-217 aryl hydrocarbon receptor Homo sapiens 255-280 16263690-8 2005 Our results are cause for concern as they suggest an AhR-independent pathway through which non-coplanar PCBs modulate phagocytosis, the immune system"s first line of defense, possibly increasing the risk to developing infectious disease. Polychlorinated Biphenyls 104-108 aryl hydrocarbon receptor Homo sapiens 53-56 16111922-4 2005 The AHR mRNA expression levels exhibited significant positive correlations with total TEQs and most of individual congener TEQs derived from polychorinated dibenzo-p-dioxins, dibenzofurans and non-ortho coplanar polychorinated biphenyls (PCBs), indicating the transcriptional up-regulation of AHR expression by these congeners. Polychlorinated Biphenyls 238-242 aryl hydrocarbon receptor Homo sapiens 4-7 15681594-1 2005 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates immunosuppression induced by a variety of ubiquitous environmental pollutants, including polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and dioxins. Polychlorinated Biphenyls 216-241 aryl hydrocarbon receptor Homo sapiens 31-34 15456928-4 2004 The structural similarity of PBDEs to other polyhalogenated aromatic hydrocarbons such as PCBs, has raised concerns that PBDEs might act as agonists for the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 90-94 aryl hydrocarbon receptor Homo sapiens 157-182 15667070-4 2005 Light produced by the extracts is a function of the concentrations and potencies of those compounds with an affinity for Ah-receptor (certain polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and dioxins/ furans). Polychlorinated Biphenyls 176-201 aryl hydrocarbon receptor Homo sapiens 121-132 15456928-4 2004 The structural similarity of PBDEs to other polyhalogenated aromatic hydrocarbons such as PCBs, has raised concerns that PBDEs might act as agonists for the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 90-94 aryl hydrocarbon receptor Homo sapiens 184-187 11604033-1 2001 Quantitative spectroscopic data-activity relationship (QSDAR) models for polychlorinated dibenzofurans (PCDFs), dibenzodioxins (PCDDs), and biphenyls (PCBs) binding to the aryl hydrocarbon receptor (AhR) have been developed based on simulated (13)C nuclear magnetic resonance (NMR) data. Polychlorinated Biphenyls 151-155 aryl hydrocarbon receptor Homo sapiens 172-197 14754570-2 2004 In rodents, PCBs bind to the aryl hydrocarbon (AhR) and pregnane X receptors (PXR) inducing the expression of catabolic cytochrome p450 enzymes of the CYP1A and 3A families. Polychlorinated Biphenyls 12-16 aryl hydrocarbon receptor Homo sapiens 47-50 12972062-1 2003 Aryl hydrocarbons such as dioxins, polychlorinated biphenyls and polyaromatic hydrocarbons bind to the cellular aryl hydrocarbon receptor (AhR) in the initial step of their metabolism. Polychlorinated Biphenyls 35-60 aryl hydrocarbon receptor Homo sapiens 139-142 11604033-1 2001 Quantitative spectroscopic data-activity relationship (QSDAR) models for polychlorinated dibenzofurans (PCDFs), dibenzodioxins (PCDDs), and biphenyls (PCBs) binding to the aryl hydrocarbon receptor (AhR) have been developed based on simulated (13)C nuclear magnetic resonance (NMR) data. Polychlorinated Biphenyls 151-155 aryl hydrocarbon receptor Homo sapiens 199-202 11604033-11 2001 The QSDAR models provide a rapid, simple and valid way to model the PCDF, PCDD, and PCB binding activity in relation to the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 84-87 aryl hydrocarbon receptor Homo sapiens 124-149 11604033-11 2001 The QSDAR models provide a rapid, simple and valid way to model the PCDF, PCDD, and PCB binding activity in relation to the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 84-87 aryl hydrocarbon receptor Homo sapiens 151-154 11453672-5 2001 The strong positive association between concentrations of dioxin-like PCB/DD/DFs and non-dioxin-like PCBs will in future epidemiological studies make it difficult to separate Ah receptor-dependent effects from non-Ah receptor-dependent effects. Polychlorinated Biphenyls 101-105 aryl hydrocarbon receptor Homo sapiens 175-186 11509745-4 2001 As a parameter of AhR activation, induction of CYP1A-mediated 7-ethoxyresorufin O-deethylase (EROD) activity was determined in the human hepatoblastoma cell line HepG2 treated with the PCBs IUPAC Nos. Polychlorinated Biphenyls 185-189 aryl hydrocarbon receptor Homo sapiens 18-21 11275356-2 2001 Some PCBs exert dioxin-like activities mediated through the aryl hydrocarbon receptor. Polychlorinated Biphenyls 5-9 aryl hydrocarbon receptor Homo sapiens 60-85 10448124-5 1999 Of the four AhR/ARNT pairs tested with PCDD, PCDF, and non-ortho PCB congeners, three exhibited high activity (rainbow trout AhR2alpha, zebrafish AhR2, and human AhR), while rainbow trout AhR2beta had very weak or no activity. Polychlorinated Biphenyls 65-68 aryl hydrocarbon receptor Homo sapiens 12-15 10448124-6 1999 Comparisons between these AhRs showed that while mono-ortho PCBs were able to activate the human AhR, they were generally ineffective in activating rainbow trout and zebrafish AhR2s. Polychlorinated Biphenyls 60-64 aryl hydrocarbon receptor Homo sapiens 26-29 9745906-1 1998 Like dioxin, some polychlorinated biphenyl (PCB) congeners produce toxicity by binding to an aryl hydrocarbon (Ah) receptor. Polychlorinated Biphenyls 18-42 aryl hydrocarbon receptor Homo sapiens 93-123 9890193-3 1999 These PCBs were selected for their varying binding activities with the aryl hydrocarbon (Ah) receptor and differences in their induction of cytochrome P450. Polychlorinated Biphenyls 6-10 aryl hydrocarbon receptor Homo sapiens 71-101 9745906-1 1998 Like dioxin, some polychlorinated biphenyl (PCB) congeners produce toxicity by binding to an aryl hydrocarbon (Ah) receptor. Polychlorinated Biphenyls 44-47 aryl hydrocarbon receptor Homo sapiens 93-123 9539012-9 1998 Collectively, these data confirm that AhR-focused objectives unintentionally created the impression that nonplanar PCBs have little if any potential for hazards to humans and wildlife. Polychlorinated Biphenyls 115-119 aryl hydrocarbon receptor Homo sapiens 38-41 9520341-1 1998 Research into the mechanism of toxicity of PCBs has focused on the Ah receptor. Polychlorinated Biphenyls 43-47 aryl hydrocarbon receptor Homo sapiens 67-78 9118871-3 1996 Toxic responses such as thymic atrophy, weight loss, immunotoxicity, and acute lethality, as well as induction of cytochrome P4501A1, have been correlated with the relative affinity of PCBs, PCDFs, and PCDDs for the AhR. Polychlorinated Biphenyls 185-189 aryl hydrocarbon receptor Homo sapiens 216-219 35545163-6 2022 A number of PCNs, particularly hexachloronaphthalene congeners, elicit AhR mediated responses that are similar to, and occur within similar potency ranges as most dioxin-like polychlorinated biphenyls (PCBs) and some chlorinated dibenzo-p-dioxins and furans (PCDD/Fs), suggesting a relationship based on molecular size and configuration between these contaminants. Polychlorinated Biphenyls 175-200 aryl hydrocarbon receptor Homo sapiens 71-74 8843409-2 1996 The PCBs, in common with other compounds such as the dioxins, have been shown to exert some biological actions mediated through the aryl hydrocarbon receptor. Polychlorinated Biphenyls 4-8 aryl hydrocarbon receptor Homo sapiens 132-157 8568836-9 1995 It is possible that interaction of PCBs with the Ah receptor and activation of the cytochrome P450 1A subfamily are involved in this pathology. Polychlorinated Biphenyls 35-39 aryl hydrocarbon receptor Homo sapiens 49-60 7940984-1 1994 The aromatic hydrocarbon (AH) (dioxin) receptor was discovered almost 20 years ago and achieved notoriety as the front-line site of action of highly toxic environmental chemicals such as halogenated dioxins and polychlorinated biphenyls. Polychlorinated Biphenyls 211-236 aryl hydrocarbon receptor Homo sapiens 4-47 8119253-0 1993 Binding of polychlorinated biphenyls to the aryl hydrocarbon receptor. Polychlorinated Biphenyls 11-36 aryl hydrocarbon receptor Homo sapiens 44-69 8119253-1 1993 A new thermodynamic model for calculating the dissociation constants of complexes formed between the aryl hydrocarbon receptor (AhR) and polychlorinated biphenyls (PCBs) is reported. Polychlorinated Biphenyls 137-162 aryl hydrocarbon receptor Homo sapiens 101-126 8119253-1 1993 A new thermodynamic model for calculating the dissociation constants of complexes formed between the aryl hydrocarbon receptor (AhR) and polychlorinated biphenyls (PCBs) is reported. Polychlorinated Biphenyls 137-162 aryl hydrocarbon receptor Homo sapiens 128-131 8119253-1 1993 A new thermodynamic model for calculating the dissociation constants of complexes formed between the aryl hydrocarbon receptor (AhR) and polychlorinated biphenyls (PCBs) is reported. Polychlorinated Biphenyls 164-168 aryl hydrocarbon receptor Homo sapiens 101-126 8119253-1 1993 A new thermodynamic model for calculating the dissociation constants of complexes formed between the aryl hydrocarbon receptor (AhR) and polychlorinated biphenyls (PCBs) is reported. Polychlorinated Biphenyls 164-168 aryl hydrocarbon receptor Homo sapiens 128-131 8119253-2 1993 The free energies of binding of PCBs to AhR are controlled by their lipophilicities, electron affinities, and entropies. Polychlorinated Biphenyls 32-36 aryl hydrocarbon receptor Homo sapiens 40-43 8119253-4 1993 We present evidence supporting the hypothesis that the majority of PCBs are likely to interact with AhR in their nonplanar conformations. Polychlorinated Biphenyls 67-71 aryl hydrocarbon receptor Homo sapiens 100-103 8119253-5 1993 In addition, we demonstrate that the affinities of PCBs for AhR relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin correlate with corresponding toxic equivalency factors in animals. Polychlorinated Biphenyls 51-55 aryl hydrocarbon receptor Homo sapiens 60-63 8568836-3 1995 These PCBs were selected for their varying binding avidities with the aryl hydrocarbon (Ah) receptor and differences in their induction of cytochrome P450. Polychlorinated Biphenyls 6-10 aryl hydrocarbon receptor Homo sapiens 70-100 35545163-6 2022 A number of PCNs, particularly hexachloronaphthalene congeners, elicit AhR mediated responses that are similar to, and occur within similar potency ranges as most dioxin-like polychlorinated biphenyls (PCBs) and some chlorinated dibenzo-p-dioxins and furans (PCDD/Fs), suggesting a relationship based on molecular size and configuration between these contaminants. Polychlorinated Biphenyls 202-206 aryl hydrocarbon receptor Homo sapiens 71-74 33513480-1 2021 In this study, an AhR-responsive reporter-gene cell-based bioassay CALUX was used to assess the biological potency of dioxins and dioxin-like PCBs (dl-PCBs) in top soil samples collected from a former airbase (A-So) and remote regions from urban and agricultural areas in Thua Thien Hue, Vietnam. Polychlorinated Biphenyls 142-146 aryl hydrocarbon receptor Homo sapiens 18-21 35038666-1 2022 The suitability of the AhR reporter gene bioassays to screen the presence of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in sewage sludge (SL) and related hydrochar (HC) was here investigated. Polychlorinated Biphenyls 144-169 aryl hydrocarbon receptor Homo sapiens 23-26 33021979-7 2020 co-planar PCB metabolite exposure (Lext H-1: 1.95-3.91) results in activation of AhR (Eralpha/beta)/Nrf2, Rev-Erbbeta, Erralpha, Dio3 (Dio2) and Tralpha limbs with a Delta Cmicro contraction of 0.89 and Delta Cmicro expansion of 1.05 as compared to p-dioxin. Polychlorinated Biphenyls 10-13 aryl hydrocarbon receptor Homo sapiens 83-86 33021979-8 2020 co-, ortho-planar PCB metabolite exposure results in activation of Car/PxR, Pparalpha (Srebf1,-Lxrbeta), Arnt (AhR-Erbeta), AR, Dio1 (Dio2) and Trbeta limbs with a Delta Cmicro contraction of 0.73 and Delta Cmicro expansion of 1.18 (as compared to p-dioxin). Polychlorinated Biphenyls 18-21 aryl hydrocarbon receptor Homo sapiens 111-114 30991879-2 2019 Aryl hydrocarbon receptor (AhR) ligands, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs), are endocrine disrupting chemicals associated with nonalcoholic fatty liver disease. Polychlorinated Biphenyls 98-123 aryl hydrocarbon receptor Homo sapiens 0-25 30991879-2 2019 Aryl hydrocarbon receptor (AhR) ligands, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs), are endocrine disrupting chemicals associated with nonalcoholic fatty liver disease. Polychlorinated Biphenyls 98-123 aryl hydrocarbon receptor Homo sapiens 27-30 31159144-7 2019 The results indicated that PCBs 20, 52 and 56 reduced the expression of AhR, while elevated that of CAR and PXR, with thresholds at low micromolar concentrations. Polychlorinated Biphenyls 27-31 aryl hydrocarbon receptor Homo sapiens 72-75 27613629-2 2018 In vitro bioassays, based on 7-ethoxyresorufin-O-deethylase (EROD) and the activity of cytochrome P450 1A1 and the aryl hydrogen receptor (AhR) pathway, are employed for the evaluation of bioanalytical equivalents (BEQ) of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) from a wide variety of sample matrices. Polychlorinated Biphenyls 309-334 aryl hydrocarbon receptor Homo sapiens 139-142 27613629-2 2018 In vitro bioassays, based on 7-ethoxyresorufin-O-deethylase (EROD) and the activity of cytochrome P450 1A1 and the aryl hydrogen receptor (AhR) pathway, are employed for the evaluation of bioanalytical equivalents (BEQ) of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) from a wide variety of sample matrices. Polychlorinated Biphenyls 336-340 aryl hydrocarbon receptor Homo sapiens 139-142 28839207-0 2017 Relationships between serum-induced AhR bioactivity or mitochondrial inhibition and circulating polychlorinated biphenyls (PCBs). Polychlorinated Biphenyls 96-121 aryl hydrocarbon receptor Homo sapiens 36-39 28839207-0 2017 Relationships between serum-induced AhR bioactivity or mitochondrial inhibition and circulating polychlorinated biphenyls (PCBs). Polychlorinated Biphenyls 123-127 aryl hydrocarbon receptor Homo sapiens 36-39 28839207-5 2017 Linear regression analysis demonstrated that total toxic equivalence (TEQ) values and polychlorinated biphenyls (PCBs) were significantly correlated with AhR bioactivity (positively) and ATP concentration (negatively). Polychlorinated Biphenyls 86-111 aryl hydrocarbon receptor Homo sapiens 154-157 28839207-5 2017 Linear regression analysis demonstrated that total toxic equivalence (TEQ) values and polychlorinated biphenyls (PCBs) were significantly correlated with AhR bioactivity (positively) and ATP concentration (negatively). Polychlorinated Biphenyls 113-117 aryl hydrocarbon receptor Homo sapiens 154-157 28839207-6 2017 Serum AhR bioactivities were positively associated with some PCBs, regardless of their dioxin-like properties, but only dioxin-like PCBs stimulated AhR bioactivity. Polychlorinated Biphenyls 61-65 aryl hydrocarbon receptor Homo sapiens 6-9 28839207-6 2017 Serum AhR bioactivities were positively associated with some PCBs, regardless of their dioxin-like properties, but only dioxin-like PCBs stimulated AhR bioactivity. Polychlorinated Biphenyls 132-136 aryl hydrocarbon receptor Homo sapiens 148-151 28501025-7 2017 In the AhR assay using a sensitive DR-EcoScreen cell line, five of the 25 PCB congeners showed agonistic activity. Polychlorinated Biphenyls 74-77 aryl hydrocarbon receptor Homo sapiens 7-10 28501025-10 2017 These results suggest that unintentional PCBs in pigments and chemical products might act as agonists and/or antagonists against ERalpha/beta, AR, GR, and AhR, and some of the PCBs might disrupt endocrine functions via multiple receptors and/or simultaneously induce dioxin-like activity via AhR. Polychlorinated Biphenyls 176-180 aryl hydrocarbon receptor Homo sapiens 292-295 28501025-8 2017 We newly found that PCB-1, -35 and -56 can act as AhR agonists. Polychlorinated Biphenyls 20-23 aryl hydrocarbon receptor Homo sapiens 50-53 28501025-10 2017 These results suggest that unintentional PCBs in pigments and chemical products might act as agonists and/or antagonists against ERalpha/beta, AR, GR, and AhR, and some of the PCBs might disrupt endocrine functions via multiple receptors and/or simultaneously induce dioxin-like activity via AhR. Polychlorinated Biphenyls 41-45 aryl hydrocarbon receptor Homo sapiens 155-158 28501025-10 2017 These results suggest that unintentional PCBs in pigments and chemical products might act as agonists and/or antagonists against ERalpha/beta, AR, GR, and AhR, and some of the PCBs might disrupt endocrine functions via multiple receptors and/or simultaneously induce dioxin-like activity via AhR. Polychlorinated Biphenyls 41-45 aryl hydrocarbon receptor Homo sapiens 292-295 25668756-2 2015 In general, dioxin-like polychlorinated biphenyls (PCBs) exhibit a ligand-dependent activation of AhR-signaling. Polychlorinated Biphenyls 24-49 aryl hydrocarbon receptor Homo sapiens 98-101 28351761-4 2017 By comparing cytokine and chemokine expression profiles in human lung adenocarcinoma cell line CL5 treated with AhR agonists and the non-AhR agonist polychlorinated biphenyl (PCB) 39, we identified a target cytokine of environmental AhR agonist exposure of in the lungs. Polychlorinated Biphenyls 149-173 aryl hydrocarbon receptor Homo sapiens 112-115 28351761-4 2017 By comparing cytokine and chemokine expression profiles in human lung adenocarcinoma cell line CL5 treated with AhR agonists and the non-AhR agonist polychlorinated biphenyl (PCB) 39, we identified a target cytokine of environmental AhR agonist exposure of in the lungs. Polychlorinated Biphenyls 149-173 aryl hydrocarbon receptor Homo sapiens 137-140 28351761-4 2017 By comparing cytokine and chemokine expression profiles in human lung adenocarcinoma cell line CL5 treated with AhR agonists and the non-AhR agonist polychlorinated biphenyl (PCB) 39, we identified a target cytokine of environmental AhR agonist exposure of in the lungs. Polychlorinated Biphenyls 149-173 aryl hydrocarbon receptor Homo sapiens 137-140 26041783-4 2015 High-affinity ligands of AHR have been classically defined as xenobiotics, such as polychlorinated biphenyls and dioxins. Polychlorinated Biphenyls 83-108 aryl hydrocarbon receptor Homo sapiens 25-28 27055685-9 2017 Other AhR ligands (3-methylcholanthrene and PCB 126) decreased ADH1B, 4 and 6 mRNAs by more than 78 and 55 %, respectively (p < 0.01). Polychlorinated Biphenyls 44-47 aryl hydrocarbon receptor Homo sapiens 6-9 25668756-2 2015 In general, dioxin-like polychlorinated biphenyls (PCBs) exhibit a ligand-dependent activation of AhR-signaling. Polychlorinated Biphenyls 51-55 aryl hydrocarbon receptor Homo sapiens 98-101 24355420-1 2014 The aryl hydrocarbon receptor (AhR) is an important mediator of toxic responses after exposure to xenobiotics including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like polychlorinated biphenyls (PCBs). Polychlorinated Biphenyls 179-204 aryl hydrocarbon receptor Homo sapiens 4-29 25646150-7 2015 We identified pollutants associated with mammary cancer belonging to the dioxin like-PCB family (notably PCB-118, -156, -105, -114) that were already pointed out in human epidemiological studies on breast cancer, and that fit with the fundamental role of the Aryl Hydrocarbon Receptor in the promotion of breast cancer. Polychlorinated Biphenyls 85-88 aryl hydrocarbon receptor Homo sapiens 259-284 25646150-7 2015 We identified pollutants associated with mammary cancer belonging to the dioxin like-PCB family (notably PCB-118, -156, -105, -114) that were already pointed out in human epidemiological studies on breast cancer, and that fit with the fundamental role of the Aryl Hydrocarbon Receptor in the promotion of breast cancer. Polychlorinated Biphenyls 105-108 aryl hydrocarbon receptor Homo sapiens 259-284 24858058-1 2014 Polychlorinated Dibenzodioxins (PCDDs), Dibenzofurans (PCDFs) and Biphenyls (PCBs) are industrial compounds or byproducts that can cause toxic effects after binding to aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 77-81 aryl hydrocarbon receptor Homo sapiens 168-193 24858058-1 2014 Polychlorinated Dibenzodioxins (PCDDs), Dibenzofurans (PCDFs) and Biphenyls (PCBs) are industrial compounds or byproducts that can cause toxic effects after binding to aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 77-81 aryl hydrocarbon receptor Homo sapiens 195-198 24858058-2 2014 But the mechanism about PCDDs, PCDFs and PCBs binding to AhR is unclear. Polychlorinated Biphenyls 41-45 aryl hydrocarbon receptor Homo sapiens 57-60 24858058-3 2014 To study the interaction and significant amino acid residues in binding of PCDDs, PCDFs and PCBs to AhR, a docking-based Comparative Molecular Similarity Indices Analysis (CoMSIA) was performed on a set of structurally diverse PCDDs, PCDFs and PCBs with known binding affinities. Polychlorinated Biphenyls 92-96 aryl hydrocarbon receptor Homo sapiens 100-103 24858058-3 2014 To study the interaction and significant amino acid residues in binding of PCDDs, PCDFs and PCBs to AhR, a docking-based Comparative Molecular Similarity Indices Analysis (CoMSIA) was performed on a set of structurally diverse PCDDs, PCDFs and PCBs with known binding affinities. Polychlorinated Biphenyls 244-248 aryl hydrocarbon receptor Homo sapiens 100-103 24521260-1 2014 Polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are major environmental pollutants, and their effects on the human body critically depend on the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 0-25 aryl hydrocarbon receptor Homo sapiens 177-202 24521260-1 2014 Polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are major environmental pollutants, and their effects on the human body critically depend on the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 0-25 aryl hydrocarbon receptor Homo sapiens 204-207 24521260-1 2014 Polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are major environmental pollutants, and their effects on the human body critically depend on the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 27-31 aryl hydrocarbon receptor Homo sapiens 177-202 24521260-1 2014 Polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are major environmental pollutants, and their effects on the human body critically depend on the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 27-31 aryl hydrocarbon receptor Homo sapiens 204-207 24599232-6 2014 AhR activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and some polychlorinated biphenyls is associated with an increase in cardiovascular disease in humans and in mice. Polychlorinated Biphenyls 63-88 aryl hydrocarbon receptor Homo sapiens 0-3 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Polychlorinated Biphenyls 15-40 aryl hydrocarbon receptor Homo sapiens 157-196 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Polychlorinated Biphenyls 42-46 aryl hydrocarbon receptor Homo sapiens 157-196 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Polychlorinated Biphenyls 70-74 aryl hydrocarbon receptor Homo sapiens 157-196 24824450-1 2014 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the responses to toxic environmental chemicals such as TCDD or dioxin-like PCBs. Polychlorinated Biphenyls 176-180 aryl hydrocarbon receptor Homo sapiens 4-29 24824450-1 2014 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the responses to toxic environmental chemicals such as TCDD or dioxin-like PCBs. Polychlorinated Biphenyls 176-180 aryl hydrocarbon receptor Homo sapiens 31-34 24355420-1 2014 The aryl hydrocarbon receptor (AhR) is an important mediator of toxic responses after exposure to xenobiotics including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like polychlorinated biphenyls (PCBs). Polychlorinated Biphenyls 179-204 aryl hydrocarbon receptor Homo sapiens 31-34 24355420-1 2014 The aryl hydrocarbon receptor (AhR) is an important mediator of toxic responses after exposure to xenobiotics including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like polychlorinated biphenyls (PCBs). Polychlorinated Biphenyls 206-210 aryl hydrocarbon receptor Homo sapiens 4-29 24355420-1 2014 The aryl hydrocarbon receptor (AhR) is an important mediator of toxic responses after exposure to xenobiotics including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like polychlorinated biphenyls (PCBs). Polychlorinated Biphenyls 206-210 aryl hydrocarbon receptor Homo sapiens 31-34 23424013-1 2013 Polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) cause toxic effects after binding to an intracellular cytosolic receptor called the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 83-108 aryl hydrocarbon receptor Homo sapiens 200-225 24236133-3 2013 Monitoring of dioxin-like PCBs in transgenic plants carrying the mammalian aryl hydrocarbon receptor (AHR) has been reported previously. Polychlorinated Biphenyls 26-30 aryl hydrocarbon receptor Homo sapiens 75-100 24236133-3 2013 Monitoring of dioxin-like PCBs in transgenic plants carrying the mammalian aryl hydrocarbon receptor (AHR) has been reported previously. Polychlorinated Biphenyls 26-30 aryl hydrocarbon receptor Homo sapiens 102-105 23690076-4 2013 RePs of 21 polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls that exhibit effects mediated through the AhR were determined by use of the H4IIE-luc assay. Polychlorinated Biphenyls 93-118 aryl hydrocarbon receptor Homo sapiens 161-164 23850706-0 2013 Molecular docking, molecular dynamics simulation, and structure-based 3D-QSAR studies on the aryl hydrocarbon receptor agonistic activity of hydroxylated polychlorinated biphenyls. Polychlorinated Biphenyls 154-179 aryl hydrocarbon receptor Homo sapiens 93-118 23850706-1 2013 The binding interactions between hydroxylated polychlorinated biphenyls (HO-PCBs) and the aryl hydrocarbon receptor (AhR) are suspected of causing toxic effects. Polychlorinated Biphenyls 46-71 aryl hydrocarbon receptor Homo sapiens 90-115 23850706-1 2013 The binding interactions between hydroxylated polychlorinated biphenyls (HO-PCBs) and the aryl hydrocarbon receptor (AhR) are suspected of causing toxic effects. Polychlorinated Biphenyls 46-71 aryl hydrocarbon receptor Homo sapiens 117-120 23424013-1 2013 Polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) cause toxic effects after binding to an intracellular cytosolic receptor called the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 83-108 aryl hydrocarbon receptor Homo sapiens 227-230 23424013-1 2013 Polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) cause toxic effects after binding to an intracellular cytosolic receptor called the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 110-114 aryl hydrocarbon receptor Homo sapiens 200-225 23424013-1 2013 Polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) cause toxic effects after binding to an intracellular cytosolic receptor called the aryl hydrocarbon receptor (AhR). Polychlorinated Biphenyls 110-114 aryl hydrocarbon receptor Homo sapiens 227-230