PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15199134-8 2004 Surprisingly, gamma-H2AX foci were also induced in Ercc1(-/-) cells by MMC treatment. Mitomycin 71-74 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 51-56 16756962-0 2006 XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin C in prostate cancer cells: role of ERCC1 in homologous recombination repair. Mitomycin 61-72 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 11-16 16756962-3 2006 Downregulation of ERCC1 sensitised DU145 and PC3 cells to cisplatin and mitomycin C. Mitomycin 72-83 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 18-23 15199134-11 2004 In Ercc1(-/-) cells, MMC-induced gamma-H2AX foci persisted at least 48 h longer than in wild-type cells, demonstrating that Ercc1 is required for the resolution of cross-link-induced DSBs. Mitomycin 21-24 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 3-8 15199134-11 2004 In Ercc1(-/-) cells, MMC-induced gamma-H2AX foci persisted at least 48 h longer than in wild-type cells, demonstrating that Ercc1 is required for the resolution of cross-link-induced DSBs. Mitomycin 21-24 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 124-129 9862190-6 1998 These results indicate that both the XPF and ERCC1 proteins are required to repair UV- and MMC-induced DNA damage. Mitomycin 91-94 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 45-50 8065913-1 1994 The human excision repair gene ERCC-1 gene restores normal resistance to UV and mitomycin C in excision repair deficient chinese hamster ovary cells of complementation group 1. Mitomycin 80-91 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 31-37 3347205-1 1988 The human DNA-excision repair gene ERCC-1 is cloned by its ability to correct the excision-repair defect of the ultraviolet light- and mitomycin-C-sensitive CHO mutant cell line 43-3B. Mitomycin 135-146 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 35-41 1945841-2 1991 Whereas antisense RNA did not influence the survival of the transfected cells, a mutated cDNA generating an ERCC-1 protein with two extra amino acids in a conserved region of its C-terminal part resulted in a significant sensitization of the HeLa transfectants to mitomycin C-induced damage. Mitomycin 264-275 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 108-114 2918869-1 1989 The human DNA excision repair gene ERCC-1 complements the ultraviolet light (UV) and mitomycin C (MMC) sensitivity of CHO mutants of complementation group 1. Mitomycin 85-96 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 35-41 2918869-1 1989 The human DNA excision repair gene ERCC-1 complements the ultraviolet light (UV) and mitomycin C (MMC) sensitivity of CHO mutants of complementation group 1. Mitomycin 98-101 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 35-41 3931911-2 1985 The bioassay makes use of a repair-deficient mutant of Chinese hamster ovary cells, UV-20, which is 40 to 60 times more sensitive to mitomycin C than its wild-type parent. Mitomycin 133-144 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 84-89 2420469-1 1986 The human excision repair gene ERCC-1 was cloned after DNA mediated gene transfer to the CHO mutant 43-3B, which is sensitive to ultraviolet light and mitomycin-C. Mitomycin 151-162 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 31-37 25115435-5 2014 Finally, in particular cell models of the interaction between ERCC1 and XPF, DNA repair was decreased, as evidenced by increased phosphorylation of the histone 2AX after exposure to mitomycin C, and genomic instability was increased, as determined by comparative genomic hybridization studies. Mitomycin 182-193 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 62-67 7404270-3 1980 Although these mutants resemble xeroderma pigmentosum human mutants with respect to their repair defect and cross-sensitivity to the carcinogen 4-nitroquinoline-1-oxide, one of two clones (UV-20) is characterized by extreme hypersensitivity to MMC (80-fold as compared to the wild type). Mitomycin 244-247 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 189-194 32034146-3 2020 Here, we show that TIP60, also known as KAT5, a haplo-insufficient tumor suppressor, directly acetylates XPF at Lys911 following UV irradiation or treatment with mitomycin C and that this acetylation is required for XPF-ERCC1 complex assembly and subsequent activation. Mitomycin 162-173 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 220-225 23580445-6 2013 In particular, the compound labeled NSC 130813 [4-[(6-chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]] was shown to act synergistically with cisplatin and mitomycin C; to increase UVC-mediated cytotoxicity; to modify DNA repair as indicated by the staining of phosphorylated H2AX; and to disrupt interaction between ERCC1 and XPF in cells. Mitomycin 178-189 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 339-344 24817012-2 2014 As a consequence, ERCC1 mediates resistance to mitomycin C (MMC) and platinum chemotherapeutic agents and may predict treatment failure. Mitomycin 47-58 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 18-23 24817012-2 2014 As a consequence, ERCC1 mediates resistance to mitomycin C (MMC) and platinum chemotherapeutic agents and may predict treatment failure. Mitomycin 60-63 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 18-23 22547097-6 2012 Mutations in DNA binding domains of ERCC1-XPF render cells more sensitive to the crosslinking agent mitomycin C than to ultraviolet radiation, suggesting that the ICL repair function of ERCC1-XPF requires tighter substrate binding than NER. Mitomycin 100-111 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 36-41 22547097-6 2012 Mutations in DNA binding domains of ERCC1-XPF render cells more sensitive to the crosslinking agent mitomycin C than to ultraviolet radiation, suggesting that the ICL repair function of ERCC1-XPF requires tighter substrate binding than NER. Mitomycin 100-111 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 186-191 19713438-6 2009 Furthermore, we report that RAD51 foci are induced by cisplatin or mitomycin C independently of ERCC1, but that mitomycin C-induced HR measured in a reporter construct is impaired in ERCC1-defective cells. Mitomycin 112-123 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 183-188