PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16705174-6 2006 cyclin D1(-/-) cells showed increased Rho GTP and ROCKII activity and signaling, with increased phosphorylation of LIM kinase, cofilin (Ser3), and myosin light chain 2 (Thr18/Ser19). Guanosine Triphosphate 42-45 cyclin D1 Homo sapiens 0-9 21242975-8 2011 We have also observed that CycD1-Cdk4 phosphorylates the Ral GEF Rgl2 "in vitro" and that CycD1-Cdk4 activity stimulates accumulation of the Ral GTP active forms. Guanosine Triphosphate 145-148 cyclin D1 Homo sapiens 90-95 18806267-5 2008 HMW-HA binding to CD44 selectively inhibits the GTP loading of Rac and Rac-dependent signaling to the cyclin D1 gene, whereas LMW-HA binding to CD44 selectively stimulates ERK activation and ERK-dependent cyclin D1 gene expression. Guanosine Triphosphate 48-51 cyclin D1 Homo sapiens 102-111