PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9228059-5	1997	Direct binding of Rac1 and Rac2 to p67(phox) was shown using a fluorescent analog of GTP (methylanthraniloyl guanosine-5"-[beta,gamma-imido]triphosphate) bound to Rac as a reporter group.	Guanosine Triphosphate	85-88	CD33 molecule	Homo sapiens	35-38	
11896062-5	2002	We now show that a single chimeric protein, consisting of residues 1-212 of p67(phox) and full-length Rac1 (residues 1-192), prenylated in vitro and exchanged to GTP, becomes a potent oxidase activator in the absence of any other component or stimulus.	Guanosine Triphosphate	162-165	CD33 molecule	Homo sapiens	76-79	
10455184-2	1999	During formation of the active oxidase complex at the membrane, the GTP-bound Rac appears to interact with the N-terminal region of p67(phox), another indispensable activator that translocates from the cytosol upon phagocyte stimulation.	Guanosine Triphosphate	68-71	CD33 molecule	Homo sapiens	132-135	
9642115-7	1998	We also showed that GTP-Cdc42 binds p67-phox N-terminus similar to GTP-Rac.	Guanosine Triphosphate	20-23	CD33 molecule	Homo sapiens	36-39	
24598074-4	2014	The participation of Rac is expressed in the following sequence: (1) Translocation of the RacGDP-RhoGDI complex to the membrane; (2) Dissociation of RacGDP from RhoGDI; (3) GDP to GTP exchange on Rac, mediated by a guanine nucleotide exchange factor; (4) Binding of RacGTP to p67(phox); (5) Induction of a conformational change in p67(phox), promoting interaction with Nox2.	Guanosine Triphosphate	180-183	CD33 molecule	Homo sapiens	276-279	
24598074-4	2014	The participation of Rac is expressed in the following sequence: (1) Translocation of the RacGDP-RhoGDI complex to the membrane; (2) Dissociation of RacGDP from RhoGDI; (3) GDP to GTP exchange on Rac, mediated by a guanine nucleotide exchange factor; (4) Binding of RacGTP to p67(phox); (5) Induction of a conformational change in p67(phox), promoting interaction with Nox2.	Guanosine Triphosphate	180-183	CD33 molecule	Homo sapiens	331-334	
22144277-3	2012	Rac in the GTP-bound form directly binds to the oxidase activator p67(                   phox                 ), which in turn interacts with Nox2, leading to superoxide production.	Guanosine Triphosphate	11-14	CD33 molecule	Homo sapiens	66-69	
22144277-4	2012	Rac also participates in activation of the nonphagocytic oxidase Nox1; in this case, GTP-bound Rac functions by interacting with Noxa1, a p67(                   phox                 )-related protein that is required for Nox1 activation.	Guanosine Triphosphate	85-88	CD33 molecule	Homo sapiens	138-199	
12186557-3	2002	(2) p67(phox) inhibits GTP hydrolysis on Rac whereas p47(phox) has no effect on Rac GTPase activity.	Guanosine Triphosphate	23-26	CD33 molecule	Homo sapiens	4-7	
11333112-8	2001	Subsequently, p40-phox, responsible for maintaining the resting state of NADPH oxidase, is separated from other two cytosolic phox proteins following an attachment of the active form of small GTP-binding protein Rac to p67-phox.	Guanosine Triphosphate	192-195	CD33 molecule	Homo sapiens	219-222	
11090627-0	2000	Structure of the TPR domain of p67phox in complex with Rac.GTP.	Guanosine Triphosphate	59-62	CD33 molecule	Homo sapiens	31-34	
10486263-3	1999	Rac is a GTPase that in the GTP-bound state binds p67phox to activate NADPH oxidase.	Guanosine Triphosphate	9-12	CD33 molecule	Homo sapiens	50-53	
9642115-2	1998	GTP-bound Rac binds to the cytosol protein p67-phox enabling it to participate in oxidase assembly.	Guanosine Triphosphate	0-3	CD33 molecule	Homo sapiens	43-46	
9642115-4	1998	Previous studies showed that Rac/p67-phox binding is GTP-dependent and that several Rac1 mutants lost the ability to activate the oxidase even though they still bound p67-phox.	Guanosine Triphosphate	53-56	CD33 molecule	Homo sapiens	33-36	
8939991-6	1996	O-2 production, in the absence of p47(phox), was dependent on: high molar ratios of p67(phox) and Rac1 to cytochrome b559, Rac1 being in the GTP-bound form, cytochrome b559 being saturated with FAD, and an optimal concentration of amphiphile.	Guanosine Triphosphate	141-144	CD33 molecule	Homo sapiens	84-87	
8939991-6	1996	O-2 production, in the absence of p47(phox), was dependent on: high molar ratios of p67(phox) and Rac1 to cytochrome b559, Rac1 being in the GTP-bound form, cytochrome b559 being saturated with FAD, and an optimal concentration of amphiphile.	Guanosine Triphosphate	141-144	CD33 molecule	Homo sapiens	88-92	
8071369-4	1994	Binding of p67phox to GTP was less avid than that of p47phox.	Guanosine Triphosphate	22-25	CD33 molecule	Homo sapiens	11-14	
8589075-3	1995	The enzyme becomes active after assembly on a membrane bound flavocytochrome b of cytosolic factors p47 phox, p67 phox and p40 phox and of low molecular mass GTP binding proteins.	Guanosine Triphosphate	158-161	CD33 molecule	Homo sapiens	110-113	
8386165-12	1993	Arachidonate-stimulated translocation of p67-phox required both cytochrome and p47-phox and was enhanced by GTP gamma S. The mass of p47-phox and p67-phox which assembled with cytochrome b558 indicated a ternary complex with a 1:1:1 stoichiometry.	Guanosine Triphosphate	108-111	CD33 molecule	Homo sapiens	41-44