PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16253996-8	2005	Thus we propose a model in which GTP-bound Cdc42/Rac binds MLK3 and disrupts SH3-mediated autoinhibition leading to dimerization and activation loop autophosphorylation.	Guanosine Triphosphate	33-36	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	59-63	
9003778-2	1996	Cdc42 and the related small GTP binding protein Rac1 can activate the SAPK/JNK and p38/RK stress-responsive kinase cascades, suggesting that MLK-3 may have a role in upstream regulation of these pathways.	Guanosine Triphosphate	28-31	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	141-146	
9427749-4	1998	Using yeast two-hybrid analysis and in vitro dot-blots, we show that MLK2 and MLK3 interact with the activated (GTP-bound) forms of Rac and Cdc42, with a slight preference for Rac.	Guanosine Triphosphate	112-115	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	78-82	
8910292-10	1996	Furthermore, we present evidence that MLK3 binds the GTP-binding proteins Cdc42 and Rac1 in vivo and that MLK3 mediates activation of MEKK-SEK-JNK kinase cascade by Rac1 and Cdc42.	Guanosine Triphosphate	53-56	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	38-42