PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23035050-2 2013 Following experimental depletion in cell lines, WNK2 was further found to control GTP-loading of Rac1, a signalling guanosine triphosphatase involved in cell migration and motility. Guanosine Triphosphate 82-85 WNK lysine deficient protein kinase 2 Homo sapiens 48-52 18593598-4 2008 We found that WNK2 depletion decreased RhoA activation and promoted GTP-loading of Rac1, leading to stimulation of the Rac1-effector PAK1, which is the kinase responsible for subsequent phosphorylation of MEK1 at serine 298, thereby increasing MEK affinity towards ERK1/2. Guanosine Triphosphate 68-71 WNK lysine deficient protein kinase 2 Homo sapiens 14-18