PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27362234-3	2016	Crystallographic evidence from a prototypic GPCR, the beta2-adrenergic receptor (beta2AR), in complex with its cognate G protein, Gs, has provided a model for how agonist binding promotes conformational changes that propagate through the GPCR and into the nucleotide-binding pocket of the G protein alpha-subunit to catalyse GDP release, the key step required for GTP binding and activation of G proteins.	Guanosine Triphosphate	364-367	adrenoceptor beta 2	Homo sapiens	54-79	
27362234-3	2016	Crystallographic evidence from a prototypic GPCR, the beta2-adrenergic receptor (beta2AR), in complex with its cognate G protein, Gs, has provided a model for how agonist binding promotes conformational changes that propagate through the GPCR and into the nucleotide-binding pocket of the G protein alpha-subunit to catalyse GDP release, the key step required for GTP binding and activation of G proteins.	Guanosine Triphosphate	364-367	adrenoceptor beta 2	Homo sapiens	81-88	
18378118-3	2008	The cell-surface expression of alpha(2B)-AR, beta(2)-AR and AT1R, and receptor-mediated ERK1/2 activation were significantly attenuated by the GTP-bound mutant Sar1H79G, suggesting that export from the ER of these receptors is mediated through the Sar1-dependent COPII-coated vesicles.	Guanosine Triphosphate	143-146	adrenoceptor beta 2	Homo sapiens	45-55	
22628317-4	2012	Our results show that GTP-bound Rab1 interacts with the F(x)(6)LL motif of beta2AR.	Guanosine Triphosphate	22-25	adrenoceptor beta 2	Homo sapiens	75-82	
18772317-6	2008	Ternary complex formation was more sensitive to disruption by GTP with the beta(2)AR than with the beta(1)AR.	Guanosine Triphosphate	62-65	adrenoceptor beta 2	Homo sapiens	75-84	
17716866-5	2007	Expression of the GTP-bound mutant Rab2Q65L significantly attenuated the cell-surface expression of both alpha(2B)-AR and beta(2)-AR, whereas the GTP-bound mutant Rab6Q72L selectively inhibited the transport of beta(2)-AR, but not alpha(2B)-AR.	Guanosine Triphosphate	18-21	adrenoceptor beta 2	Homo sapiens	122-132	
17716866-5	2007	Expression of the GTP-bound mutant Rab2Q65L significantly attenuated the cell-surface expression of both alpha(2B)-AR and beta(2)-AR, whereas the GTP-bound mutant Rab6Q72L selectively inhibited the transport of beta(2)-AR, but not alpha(2B)-AR.	Guanosine Triphosphate	18-21	adrenoceptor beta 2	Homo sapiens	211-221	
17452637-7	2007	The monomeric beta2AR efficiently activates Gs and displays GTP-sensitive allosteric ligand-binding properties.	Guanosine Triphosphate	60-63	adrenoceptor beta 2	Homo sapiens	14-21	
17451656-4	2007	The results also show that inhibition of ROS attenuates active beta2AR-mediated binding of GTP to alpha subunits of heterotrimeric G proteins.	Guanosine Triphosphate	91-94	adrenoceptor beta 2	Homo sapiens	63-70	
15933218-1	2005	beta2-adrenoceptor-mediated activation of Gs and adenylyl cyclase or other receptor-mediated G protein activations is believed to occur by receptor-catalyzed replacement of GDP with GTP on the alpha-subunit of the G protein.	Guanosine Triphosphate	182-185	adrenoceptor beta 2	Homo sapiens	0-18	
15933218-8	2005	We discuss the results in the context of the current paradigm of receptor-mediated G protein activation and propose an additional mode of activation for beta2-adrenoceptor-G(s) adenylyl cyclase system where nucleotide exchange is not necessary and GDP and GTP play identical roles in receptor-induced Gs protein activation.	Guanosine Triphosphate	256-259	adrenoceptor beta 2	Homo sapiens	153-171	
11356949-5	2001	We examined a series of beta(2)-adrenoceptor (beta(2)AR) agonists (weak partial agonists to full agonists) for their efficacy at promoting two different steps of the G-protein activation/deactivation cycle: stabilizing the ternary complex (high-affinity, GTP-sensitive agonist binding), and steady-state GTPase activity.	Guanosine Triphosphate	255-258	adrenoceptor beta 2	Homo sapiens	24-44	
11356949-5	2001	We examined a series of beta(2)-adrenoceptor (beta(2)AR) agonists (weak partial agonists to full agonists) for their efficacy at promoting two different steps of the G-protein activation/deactivation cycle: stabilizing the ternary complex (high-affinity, GTP-sensitive agonist binding), and steady-state GTPase activity.	Guanosine Triphosphate	255-258	adrenoceptor beta 2	Homo sapiens	46-55	
8974046-10	1996	Zinterol bound to membrane beta AR labelled with (-)-[125I] cyanopindolol with higher affinity for beta 2AR than for beta 1AR; the binding to beta 2AR but not to beta 1AR was reduced by GTP gamma S (10 microM).	Guanosine Triphosphate	186-189	adrenoceptor beta 2	Homo sapiens	142-150	
10704234-10	2000	Taken together, these results indicate that the tethering of G(alpha)(s) to the beta(2)AR causes a conformational change in the receptor that stabilizes a species "trapped" between the non-guanine nucleotide-bound state and the GTP-bound form.	Guanosine Triphosphate	228-231	adrenoceptor beta 2	Homo sapiens	80-89	
9729456-5	1998	Compared with beta2ARGsalpha, basal and agonist-stimulated GTP hydrolysis was markedly decreased in beta2AR(Delta70)Gsalpha, whereas the effect of the deletion on binding of guanosine 5"-[gamma-thio]triphosphate (GTP[S]) was relatively small.	Guanosine Triphosphate	59-62	adrenoceptor beta 2	Homo sapiens	115-123	
9729456-8	1998	These findings suggest that restricting the mobility of Gsalpha relative to the beta2AR results in a decrease in G-protein inactivation by GTP hydrolysis and thereby enhanced activation of AC.	Guanosine Triphosphate	139-142	adrenoceptor beta 2	Homo sapiens	80-87	
7908406-2	1994	In the absence of agonist but in the presence of GTP, membranes from cells expressing the beta 2AR exhibited higher levels of cAMP production than did membranes from uninfected cells or from cells infected with wild-type baculovirus.	Guanosine Triphosphate	49-52	adrenoceptor beta 2	Homo sapiens	90-98