PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11956229-3	2002	Serum-depleted, nonattached cells expressing the raft SHP-2 form, but not non-raft SHP-2, display signaling events resembling those observed after fibronectin attachment, such as beta1 integrin clustering, 397Y-FAK phosphorylation, and ERK activation, and also increases Rho-GTP levels.	Guanosine Triphosphate	275-278	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	54-59	
30104724-3	2018	Here, we show that targeting the SHP2 phosphatase (encoded by PTPN11) with RMC-4550, a small-molecule allosteric inhibitor, is effective in human cancer models bearing RAS-GTP-dependent oncogenic BRAF (for example, class 3 BRAF mutants), NF1 loss or nucleotide-cycling oncogenic RAS (for example, KRASG12C).	Guanosine Triphosphate	172-175	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	33-37	
30104724-3	2018	Here, we show that targeting the SHP2 phosphatase (encoded by PTPN11) with RMC-4550, a small-molecule allosteric inhibitor, is effective in human cancer models bearing RAS-GTP-dependent oncogenic BRAF (for example, class 3 BRAF mutants), NF1 loss or nucleotide-cycling oncogenic RAS (for example, KRASG12C).	Guanosine Triphosphate	172-175	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	62-68	
30104724-5	2018	Our findings illuminate a critical function for SHP2 in promoting oncogenic RAS/MAPK pathway activation in cancers with RAS-GTP-dependent oncogenic BRAF, NF1 loss and nucleotide-cycling oncogenic KRAS.	Guanosine Triphosphate	124-127	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	48-52	
33247204-7	2021	Pre-inhibition of RAS or PTPN11, but not of PI3K or JAK-signaling, prevented TSLP-induced RAS-GTP boost.	Guanosine Triphosphate	94-97	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	25-31	
25178522-1	2014	Src homology-2 protein tyrosine phosphatase (SHP-2) that is encoded by the PTPN11 gene in humans is an intracellular signaling molecule that couples growth factor receptors to activation of the Ras small GTP-binding protein that regulates cell growth, proliferation and differentiation.	Guanosine Triphosphate	204-207	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	45-50	
25178522-1	2014	Src homology-2 protein tyrosine phosphatase (SHP-2) that is encoded by the PTPN11 gene in humans is an intracellular signaling molecule that couples growth factor receptors to activation of the Ras small GTP-binding protein that regulates cell growth, proliferation and differentiation.	Guanosine Triphosphate	204-207	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	75-81