PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17070516-4 2006 It has been demonstrated that a small GTP-binding protein, Rho, and its downstream effecter, Rho kinase (ROCK), negatively regulate endothelial nitric oxide synthase (eNOS) production. Guanosine Triphosphate 38-41 nitric oxide synthase 3 Homo sapiens 132-165 12876216-0 2003 Inhibition of GTP-dependent vesicle trafficking impairs internalization of plasmalemmal eNOS and cellular nitric oxide production. Guanosine Triphosphate 14-17 nitric oxide synthase 3 Homo sapiens 88-92 12876216-5 2003 Incubation of digitonin-permeabilized ECV304 cells with the non-hydrolyzed GTP analog, GTP-gamma-S, abrogated the BK-mediated internalization of eNOS-GFP as assessed by confocal microscopy. Guanosine Triphosphate 75-78 nitric oxide synthase 3 Homo sapiens 145-149 12876216-9 2003 These studies demonstrate that disruption of dynamin- and GTP-dependent, but clathrin-independent, vesicle trafficking pathways impairs BK-dependent cellular NO production, via inhibition of the internalization of eNOS-containing plasmalemmal vesicles. Guanosine Triphosphate 58-61 nitric oxide synthase 3 Homo sapiens 214-218 32411442-5 2020 The key proteins (Tie2, Akt, eNOS, and GTPCH I) in the guanosine triphosphate cyclohydrolase/tetrahydrobiopterin (GTPCH/BH4) pathway and Tie2/Akt/eNOS signaling pathway were evaluated in these women. Guanosine Triphosphate 55-77 nitric oxide synthase 3 Homo sapiens 29-33 32411442-5 2020 The key proteins (Tie2, Akt, eNOS, and GTPCH I) in the guanosine triphosphate cyclohydrolase/tetrahydrobiopterin (GTPCH/BH4) pathway and Tie2/Akt/eNOS signaling pathway were evaluated in these women. Guanosine Triphosphate 55-77 nitric oxide synthase 3 Homo sapiens 146-150