PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34648564-3 2021 Rhes is a Ras-related small GTP-binding protein highly expressed in the striatum that has been reported to modulate mTOR and sumoylation of mutant huntingtin to alter HD mouse model pathogenesis. Guanosine Triphosphate 28-31 huntingtin Mus musculus 147-157 30594931-9 2019 Affinity chromatography analysis of striatal lysates showed that Huntingtin is in a complex with Rac1, p85alpha subunit of PI 3-kinase, and the actin bundling protein alpha-actinin and interacts preferentially with the GTP bound form of Rac1. Guanosine Triphosphate 219-222 huntingtin Mus musculus 65-75 27559163-15 2016 We found that mutant huntingtin protein (mHtt) at the endogenous level decreases BDNF secretion from astrocytes by disrupting the conversion of GTP-Rab3a into GDP-Rab3a and that overexpressing Rab3a can rescue this deficient BDNF release and early neuropathology in HD knock-in mouse brain. Guanosine Triphosphate 144-147 huntingtin Mus musculus 21-31