PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17880011-4 2008 CA IX was recently shown to contribute to acidification of the tumor environment, by efficiently catalyzing the hydration of carbon dioxide to bicarbonate and protons with its extracellularly situated active site, leading both to the acquisition of metastasic phenotypes and to chemoresistance with weakly basic anticancer drugs. Carbon Dioxide 125-139 carbonic anhydrase 9 Homo sapiens 0-5 22675743-3 2004 The expression of CA IX is largely restricted to the epithelial cells of the gastrointestinal tract, especially the gastric epithelial cells where CA IX catalyzes the hydration of carbon dioxide to bicarbonate and protons (1, 4). Carbon Dioxide 180-194 carbonic anhydrase 9 Homo sapiens 18-23 22675743-3 2004 The expression of CA IX is largely restricted to the epithelial cells of the gastrointestinal tract, especially the gastric epithelial cells where CA IX catalyzes the hydration of carbon dioxide to bicarbonate and protons (1, 4). Carbon Dioxide 180-194 carbonic anhydrase 9 Homo sapiens 147-152 20423227-4 2010 One of these proteins is carbonic anhydrase IX (CA IX), which catalyzes the reversible hydration of carbon dioxide to carbonic acid outside the cell, leading to an acidic extracellular pH and a physiological intracellular pH. Carbon Dioxide 100-114 carbonic anhydrase 9 Homo sapiens 25-46 20423227-4 2010 One of these proteins is carbonic anhydrase IX (CA IX), which catalyzes the reversible hydration of carbon dioxide to carbonic acid outside the cell, leading to an acidic extracellular pH and a physiological intracellular pH. Carbon Dioxide 100-114 carbonic anhydrase 9 Homo sapiens 48-53 20819065-5 2010 CA IX contributes to tumour environment acidification by catalyzing the carbon dioxide hydration to bicarbonate and protons, leading to the acquisition of metastasic phenotypes and chemoresistance to weakly basic anticancer drugs and therefore to inadequate application of radio-therapeutic or chemotherapeutic anti-cancer treatment strategies. Carbon Dioxide 72-86 carbonic anhydrase 9 Homo sapiens 0-5 18666004-2 2008 Human carbonic anhydrase (hCA) hCA IX and XII isozymes are tumor associated isoforms which contribute to acidification of the tumor environment by catalyzing the hydration of carbon dioxide to bicarbonate and protons.In the present study our goal was to investigate the inhibition effects of 15 different antibiotics belonging to the following classes: Lactams, cephalosporins, macrolides etc., on the tumor associated carbonic anhydrase isozymes hCA-IX, hCA-XII and cytosolic carbonic anhydrase hCA-I and hCA-II. Carbon Dioxide 175-189 carbonic anhydrase 9 Homo sapiens 447-453 22787577-3 2012 CA IX is a dimeric protein possessing very high catalytic activity for the hydration of carbon dioxide to protons and bicarbonate. Carbon Dioxide 88-102 carbonic anhydrase 9 Homo sapiens 0-5 16996620-3 2006 CA IX contributes to acidification of the tumor environment by efficiently catalyzing the hydration of carbon dioxide to bicarbonate and protons, thereby leading to acquisition of metastatic phenotypes and chemoresistance to weakly basic anticancer drugs. Carbon Dioxide 103-117 carbonic anhydrase 9 Homo sapiens 0-5 17367605-2 2007 Carbonic anhydrase IX (CAIX) is a transmembrane enzyme involved in the reversible metabolism of carbon dioxide to carbonic acid and, hence, in physiological pH regulation. Carbon Dioxide 96-110 carbonic anhydrase 9 Homo sapiens 0-21 17367605-2 2007 Carbonic anhydrase IX (CAIX) is a transmembrane enzyme involved in the reversible metabolism of carbon dioxide to carbonic acid and, hence, in physiological pH regulation. Carbon Dioxide 96-110 carbonic anhydrase 9 Homo sapiens 23-27 17030461-1 2006 Carbonic anhydrase (CA) IX catalyzes the hydration of carbon dioxide into carbonic acid and participates in a variety of physiological and biological processes. Carbon Dioxide 54-68 carbonic anhydrase 9 Homo sapiens 0-26 34685701-4 2021 Carbonic anhydrase IX (CAIX), a regulator of cellular pH through the hydration of metabolically released pericellular CO2, was identified as a downstream mediator of the TIMP-1-CD63 signaling axis responsible for extracellular acidosis. Carbon Dioxide 118-121 carbonic anhydrase 9 Homo sapiens 0-21 15585626-2 2004 Carbonic anhydrase (CA) IX, an endogenous marker for tumor hypoxia, catalyzes the hydration of carbon dioxide into carbonic acid and contributes to the pH regulation of tumor cells. Carbon Dioxide 95-109 carbonic anhydrase 9 Homo sapiens 0-26 14567991-1 2003 Carbonic anhydrase IX (CA IX) is a cancer-associated transmembrane isoform of zinc metalloenzymes that catalyse interconversion between carbon dioxide and bicarbonate. Carbon Dioxide 136-150 carbonic anhydrase 9 Homo sapiens 23-28 11691824-1 2001 Carbonic anhydrase-9 (CA9), a transmembrane enzyme with an extracellular active site, is involved in the reversible metabolism of the carbon dioxide to carbonic acid. Carbon Dioxide 134-148 carbonic anhydrase 9 Homo sapiens 0-20 11691824-1 2001 Carbonic anhydrase-9 (CA9), a transmembrane enzyme with an extracellular active site, is involved in the reversible metabolism of the carbon dioxide to carbonic acid. Carbon Dioxide 134-148 carbonic anhydrase 9 Homo sapiens 22-25 16984378-4 2006 An increase in carbon dioxide production in the tumor environment was linked with overexpression of carbonic anhydrase 9 (CA9). Carbon Dioxide 15-29 carbonic anhydrase 9 Homo sapiens 100-120 16984378-4 2006 An increase in carbon dioxide production in the tumor environment was linked with overexpression of carbonic anhydrase 9 (CA9). Carbon Dioxide 15-29 carbonic anhydrase 9 Homo sapiens 122-125 16310354-3 2005 Several recent studies have shown that CA IX, apart from its classical enzyme activity of reversibly hydrating carbon dioxide extracellularly to facilitate the net extrusion of protons from inside to outside the cell, it can also be a key player in the modulation of cell adhesion processes and participate in the regulation of cell proliferation in response to hypoxic environment to ultimately contribute to tumour progression. Carbon Dioxide 111-125 carbonic anhydrase 9 Homo sapiens 39-44 15951534-1 2005 BACKGROUND: Carbonic anhydrase IX (MN/Ca9) catalyses the reversible metabolism of carbon dioxide to carbonic acid and has also been linked to malignant transformation and hypoxia in various cancers. Carbon Dioxide 82-96 carbonic anhydrase 9 Homo sapiens 12-33 15951534-1 2005 BACKGROUND: Carbonic anhydrase IX (MN/Ca9) catalyses the reversible metabolism of carbon dioxide to carbonic acid and has also been linked to malignant transformation and hypoxia in various cancers. Carbon Dioxide 82-96 carbonic anhydrase 9 Homo sapiens 38-41 15500003-2 2004 CA IX is a tumor-associated transmembrane antigen, which catalyzes the extracellular, reversible hydration of carbon dioxide to bicarbonate and proton and thereby contributes to acidification of extracellular milieu. Carbon Dioxide 110-124 carbonic anhydrase 9 Homo sapiens 0-5 9524195-8 1998 Furthermore, MN/CA IX has a completely conserved active site domain of CAs suggesting that it could also participate in carbon dioxide/bicarbonate homeostasis. Carbon Dioxide 120-134 carbonic anhydrase 9 Homo sapiens 16-21 34251286-3 2021 Carbonic anhydrase IX (CA IX) is expressed in pulmonary microvascular endothelial cells (PMVECs), where it contributes to CO2 and pH homeostasis, bioenergetics and angiogenesis. Carbon Dioxide 122-125 carbonic anhydrase 9 Homo sapiens 23-28 34685701-4 2021 Carbonic anhydrase IX (CAIX), a regulator of cellular pH through the hydration of metabolically released pericellular CO2, was identified as a downstream mediator of the TIMP-1-CD63 signaling axis responsible for extracellular acidosis. Carbon Dioxide 118-121 carbonic anhydrase 9 Homo sapiens 23-27 34812124-1 2021 Human carbonic anhydrase (hCAIX), an extracellular enzyme that catalyzes the reversible hydration of CO2, is often overexpressed in solid tumors. Carbon Dioxide 101-104 carbonic anhydrase 9 Homo sapiens 26-31 34074429-4 2021 In this experiment, p-nitrophenyl acetate (pNPA) was used as the substrate for the enzyme reaction, which solved the problem that capillary electrophoresis could not detect carbonate, carbon dioxide, etc., the conventional substrates of carbonic anhydrase IX. Carbon Dioxide 184-198 carbonic anhydrase 9 Homo sapiens 237-258 32983978-9 2020 Hypoxia-induced CA IX therefore mediates adaptation to microenvironmental hypoxia and acidosis directly, by enzymatically converting extracellular CO2 to bicarbonate, and indirectly, by maintaining glycolysis-permissive intracellular milieu. Carbon Dioxide 147-150 carbonic anhydrase 9 Homo sapiens 16-21 35080763-4 2021 CA IX catalyzes reversible conversion of carbon dioxide to bicarbonate ion plus proton and cooperates with a spectrum of molecules transporting ions or metabolites across the plasma membrane. Carbon Dioxide 41-55 carbonic anhydrase 9 Homo sapiens 0-5 32983978-3 2020 Hypoxia-induced carbonic anhydrase IX (CA IX) plays a critical adaptive role in response to hypoxic and acidic environments by catalytically hydrating extracellular CO2 to produce bicarbonate for buffering intracellular pH (pHi). Carbon Dioxide 165-168 carbonic anhydrase 9 Homo sapiens 16-37 32983978-3 2020 Hypoxia-induced carbonic anhydrase IX (CA IX) plays a critical adaptive role in response to hypoxic and acidic environments by catalytically hydrating extracellular CO2 to produce bicarbonate for buffering intracellular pH (pHi). Carbon Dioxide 165-168 carbonic anhydrase 9 Homo sapiens 39-44 33201250-1 2021 hCA IX is a multi-domain protein belonging to the family of hCAs which are ubiquitous zinc enzymes that catalyze the reversible hydration of CO2 to HCO3- and H+. Carbon Dioxide 141-144 carbonic anhydrase 9 Homo sapiens 0-6 32340282-1 2020 Carbonic anhydrase IX (CA-IX) plays a pivotal role in regulation of pH in tumor milieu catalyzing carbonic acid formation by hydrating CO2. Carbon Dioxide 135-138 carbonic anhydrase 9 Homo sapiens 0-21 32340282-1 2020 Carbonic anhydrase IX (CA-IX) plays a pivotal role in regulation of pH in tumor milieu catalyzing carbonic acid formation by hydrating CO2. Carbon Dioxide 135-138 carbonic anhydrase 9 Homo sapiens 23-28 32066909-2 2020 The hypoxia-regulated transmembrane protein, carbonic anhydrase CA9, converts carbon dioxide produced by the Krebs cycle to bicarbonate and protons that acidify the extracellular milieu. Carbon Dioxide 78-92 carbonic anhydrase 9 Homo sapiens 64-67 27894244-4 2018 The main enzymatic function of the CA IX protein is to catalyze the hydration of carbon dioxide into bicarbonate ions and protons. Carbon Dioxide 81-95 carbonic anhydrase 9 Homo sapiens 35-40 31146646-1 2020 Carbonic anhydrase IX (CAIX) is a tumour-associated, hypoxia-induced, membrane-bound metallo-enzyme which catalyzes the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3-) and proton (H+) ions. Carbon Dioxide 144-158 carbonic anhydrase 9 Homo sapiens 0-21 31146646-1 2020 Carbonic anhydrase IX (CAIX) is a tumour-associated, hypoxia-induced, membrane-bound metallo-enzyme which catalyzes the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3-) and proton (H+) ions. Carbon Dioxide 144-158 carbonic anhydrase 9 Homo sapiens 23-27 31146646-1 2020 Carbonic anhydrase IX (CAIX) is a tumour-associated, hypoxia-induced, membrane-bound metallo-enzyme which catalyzes the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3-) and proton (H+) ions. Carbon Dioxide 160-163 carbonic anhydrase 9 Homo sapiens 0-21 31146646-1 2020 Carbonic anhydrase IX (CAIX) is a tumour-associated, hypoxia-induced, membrane-bound metallo-enzyme which catalyzes the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3-) and proton (H+) ions. Carbon Dioxide 160-163 carbonic anhydrase 9 Homo sapiens 23-27 30383070-2 2018 Among the different genes that are upregulated by hypoxia is carbonic anhydrase IX, which combines carbon dioxide and water to form bicarbonate and hydrogen. Carbon Dioxide 99-113 carbonic anhydrase 9 Homo sapiens 61-82 27373313-1 2017 Carbonic anhydrase IX is a tumor-associated membrane-bound metallo-enzyme which catalyzes the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3-) and proton (H+) ions. Carbon Dioxide 118-132 carbonic anhydrase 9 Homo sapiens 0-21 27373313-1 2017 Carbonic anhydrase IX is a tumor-associated membrane-bound metallo-enzyme which catalyzes the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3-) and proton (H+) ions. Carbon Dioxide 134-137 carbonic anhydrase 9 Homo sapiens 0-21 26249175-2 2015 We assessed the functional activity of CAIX in two colorectal tumor models, expressing different levels of the enzyme, by measuring the rate of exchange of hyperpolarized (13)C label between bicarbonate (H(13)CO3(-)) and carbon dioxide ((13)CO2), following injection of hyperpolarized H(13)CO3(-), using (13)C-magnetic resonance spectroscopy ((13)C-MRS) magnetization transfer measurements. Carbon Dioxide 221-235 carbonic anhydrase 9 Homo sapiens 39-43 26470855-3 2016 We have evaluated the catalytic activity of CA IX heterologously expressed in Xenopus laevis oocytes by measuring the amplitude and rate of cytosolic pH changes as well as pH changes at the outer membrane surface (pHs ) during addition and removal of 5% CO2 /25 mm HCO3-, and by mass spectrometry. Carbon Dioxide 254-257 carbonic anhydrase 9 Homo sapiens 44-49 26470855-5 2016 Reduced rates of CO2 -dependent intracellular pH changes after knockdown of CA IX confirmed these findings in two breast cancer cell lines: MCF-7 and MDA-MB-231. Carbon Dioxide 17-20 carbonic anhydrase 9 Homo sapiens 76-81 27630286-1 2016 BACKGROUND/AIM: Carbonic anhydrase IX (CA9) catalyses the interconversion of carbon dioxide to carbonic acid and bicarbonate and is considered a putative biomarker of tumour hypoxia. Carbon Dioxide 77-91 carbonic anhydrase 9 Homo sapiens 16-37 27630286-1 2016 BACKGROUND/AIM: Carbonic anhydrase IX (CA9) catalyses the interconversion of carbon dioxide to carbonic acid and bicarbonate and is considered a putative biomarker of tumour hypoxia. Carbon Dioxide 77-91 carbonic anhydrase 9 Homo sapiens 39-42 24146382-1 2014 Carbonic anhydrase IX (CAIX) which is a zinc containing metalloprotein, efficiently catalyzes the reversible hydration of carbon dioxide. Carbon Dioxide 122-136 carbonic anhydrase 9 Homo sapiens 0-21 25843777-1 2015 Carbonic anhydrase IX(CA9)is a member of the carbonic anhydrase family that catalyzes the reversible hydration of carbon dioxide, and plays a key role in the regulation of pH. Carbon Dioxide 114-128 carbonic anhydrase 9 Homo sapiens 0-21 25843777-1 2015 Carbonic anhydrase IX(CA9)is a member of the carbonic anhydrase family that catalyzes the reversible hydration of carbon dioxide, and plays a key role in the regulation of pH. Carbon Dioxide 114-128 carbonic anhydrase 9 Homo sapiens 22-25 25117006-3 2015 One of the adaptive responses of tumor cells to hypoxia involves the increased expression and functional activation of carbonic anhydrase IX (CA IX), a cancer-related cell surface enzyme catalyzing the reversible conversion of carbon dioxide to bicarbonate ion and proton. Carbon Dioxide 227-241 carbonic anhydrase 9 Homo sapiens 119-140 25117006-3 2015 One of the adaptive responses of tumor cells to hypoxia involves the increased expression and functional activation of carbonic anhydrase IX (CA IX), a cancer-related cell surface enzyme catalyzing the reversible conversion of carbon dioxide to bicarbonate ion and proton. Carbon Dioxide 227-241 carbonic anhydrase 9 Homo sapiens 142-147 24146382-1 2014 Carbonic anhydrase IX (CAIX) which is a zinc containing metalloprotein, efficiently catalyzes the reversible hydration of carbon dioxide. Carbon Dioxide 122-136 carbonic anhydrase 9 Homo sapiens 23-27