PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11181493-0 2001 Glutathione S-transferase activity influences busulfan pharmacokinetics in patients with beta thalassemia major undergoing bone marrow transplantation. Busulfan 46-54 glutathione S-transferase kappa 1 Homo sapiens 0-25 15142875-2 2004 Busulfan, as well as the metabolites of cyclophosphamide, are conjugated with glutathione (GSH), catalyzed by enzymes of the glutathione S-transferase (GST) family. Busulfan 0-8 glutathione S-transferase kappa 1 Homo sapiens 125-150 15142875-2 2004 Busulfan, as well as the metabolites of cyclophosphamide, are conjugated with glutathione (GSH), catalyzed by enzymes of the glutathione S-transferase (GST) family. Busulfan 0-8 glutathione S-transferase kappa 1 Homo sapiens 152-155 12087351-0 2002 Genetic polymorphisms of glutathione S-transferase A1, the major glutathione S-transferase in human liver: consequences for enzyme expression and busulfan conjugation. Busulfan 146-154 glutathione S-transferase kappa 1 Homo sapiens 25-50 11181493-5 2001 In this study, we demonstrate that hepatic glutathione S-transferase (GST) activity correlates negatively with busulfan maximum and minimum concentrations (Pearson"s correlation r = -0.74 and -0.77, respectively) and positively with busulfan clearance (Pearson"s correlation r = 0.728) in children with thalassemia major in the age range of 2 to 15 years. Busulfan 111-119 glutathione S-transferase kappa 1 Homo sapiens 43-68 11181493-5 2001 In this study, we demonstrate that hepatic glutathione S-transferase (GST) activity correlates negatively with busulfan maximum and minimum concentrations (Pearson"s correlation r = -0.74 and -0.77, respectively) and positively with busulfan clearance (Pearson"s correlation r = 0.728) in children with thalassemia major in the age range of 2 to 15 years. Busulfan 111-119 glutathione S-transferase kappa 1 Homo sapiens 70-73 11181493-5 2001 In this study, we demonstrate that hepatic glutathione S-transferase (GST) activity correlates negatively with busulfan maximum and minimum concentrations (Pearson"s correlation r = -0.74 and -0.77, respectively) and positively with busulfan clearance (Pearson"s correlation r = 0.728) in children with thalassemia major in the age range of 2 to 15 years. Busulfan 233-241 glutathione S-transferase kappa 1 Homo sapiens 43-68 11181493-5 2001 In this study, we demonstrate that hepatic glutathione S-transferase (GST) activity correlates negatively with busulfan maximum and minimum concentrations (Pearson"s correlation r = -0.74 and -0.77, respectively) and positively with busulfan clearance (Pearson"s correlation r = 0.728) in children with thalassemia major in the age range of 2 to 15 years. Busulfan 233-241 glutathione S-transferase kappa 1 Homo sapiens 70-73 11181493-7 2001 Plasma alpha GST concentrations showed a similar correlation with busulfan kinetic parameters to that observed for hepatic GST. Busulfan 66-74 glutathione S-transferase kappa 1 Homo sapiens 13-16 11181493-8 2001 The status of hepatic GST activity accounts, at least in part, for the observed interindividual variation in busulfan kinetics, while the observed association with plasma alpha GST is difficult to explain at present. Busulfan 109-117 glutathione S-transferase kappa 1 Homo sapiens 22-25 35214132-2 2022 However, the response of busulfan is highly variable and unpredictable, whereby the pharmacogenetic interference of glutathione S-transferase (GST) has strong evidence in Caucasians and some adult Asians but not in pediatric Asian patients. Busulfan 25-33 glutathione S-transferase kappa 1 Homo sapiens 116-141 9443852-0 1998 Comparison of human liver and small intestinal glutathione S-transferase-catalyzed busulfan conjugation in vitro. Busulfan 83-91 glutathione S-transferase kappa 1 Homo sapiens 47-72 8886613-1 1996 Busulfan is eliminated by glutathione S-transferase (GST)-catalyzed conjugation with glutathione (GSH). Busulfan 0-8 glutathione S-transferase kappa 1 Homo sapiens 26-51 8886613-1 1996 Busulfan is eliminated by glutathione S-transferase (GST)-catalyzed conjugation with glutathione (GSH). Busulfan 0-8 glutathione S-transferase kappa 1 Homo sapiens 53-56 8886613-6 1996 THT+ formation rate increased linearly with busulfan concentration up to its solubility limit for all GST isoforms. Busulfan 44-52 glutathione S-transferase kappa 1 Homo sapiens 102-105 8886613-10 1996 Since the polymorphic mu-class GST catalyzed busulfan conjugation, we examined busulfan clearance in 50 patients undergoing high-dose busulfan before bone marrow transplantation. Busulfan 45-53 glutathione S-transferase kappa 1 Homo sapiens 31-34 8886613-10 1996 Since the polymorphic mu-class GST catalyzed busulfan conjugation, we examined busulfan clearance in 50 patients undergoing high-dose busulfan before bone marrow transplantation. Busulfan 79-87 glutathione S-transferase kappa 1 Homo sapiens 31-34 8886613-10 1996 Since the polymorphic mu-class GST catalyzed busulfan conjugation, we examined busulfan clearance in 50 patients undergoing high-dose busulfan before bone marrow transplantation. Busulfan 79-87 glutathione S-transferase kappa 1 Homo sapiens 31-34 35214132-2 2022 However, the response of busulfan is highly variable and unpredictable, whereby the pharmacogenetic interference of glutathione S-transferase (GST) has strong evidence in Caucasians and some adult Asians but not in pediatric Asian patients. Busulfan 25-33 glutathione S-transferase kappa 1 Homo sapiens 143-146 35214132-3 2022 This study was aimed at investigating the associations of GST genetic polymorphisms with variations in the pharmacokinetic (PK) properties of busulfan in pediatric Asian patients. Busulfan 142-150 glutathione S-transferase kappa 1 Homo sapiens 58-61 26691424-0 2016 Influence of glutathione S-transferase gene polymorphisms on busulfan pharmacokinetics and outcome of hematopoietic stem-cell transplantation in thalassemia pediatric patients. Busulfan 61-69 glutathione S-transferase kappa 1 Homo sapiens 13-38 30511436-0 2019 Effect of glutathione S-transferase genetic polymorphisms on busulfan pharmacokinetics and veno-occlusive disease in hematopoietic stem cell transplantation: A meta-analysis. Busulfan 61-69 glutathione S-transferase kappa 1 Homo sapiens 10-35 30511436-1 2019 This meta-analysis was conducted to derive an integrated conclusion about the influence of glutathione S-transferase (GST) genetic polymorphisms on busulfan pharmacokinetic (PK) parameters and veno-occlusive disease (VOD). Busulfan 148-156 glutathione S-transferase kappa 1 Homo sapiens 91-116 30511436-1 2019 This meta-analysis was conducted to derive an integrated conclusion about the influence of glutathione S-transferase (GST) genetic polymorphisms on busulfan pharmacokinetic (PK) parameters and veno-occlusive disease (VOD). Busulfan 148-156 glutathione S-transferase kappa 1 Homo sapiens 118-121 30963629-0 2019 Influence of GST polymorphisms on busulfan pharmacokinetics in Japanese children. Busulfan 34-42 glutathione S-transferase kappa 1 Homo sapiens 13-16 30963629-2 2019 Given that busulfan is mainly metabolized by glutathione S-transferase (GST), we investigated the influence of GST polymorphisms on busulfan pharmacokinetics in Japanese pediatric patients. Busulfan 11-19 glutathione S-transferase kappa 1 Homo sapiens 45-70 30963629-2 2019 Given that busulfan is mainly metabolized by glutathione S-transferase (GST), we investigated the influence of GST polymorphisms on busulfan pharmacokinetics in Japanese pediatric patients. Busulfan 11-19 glutathione S-transferase kappa 1 Homo sapiens 72-75 30963629-2 2019 Given that busulfan is mainly metabolized by glutathione S-transferase (GST), we investigated the influence of GST polymorphisms on busulfan pharmacokinetics in Japanese pediatric patients. Busulfan 132-140 glutathione S-transferase kappa 1 Homo sapiens 111-114 30963629-14 2019 CONCLUSIONS: GST polymorphisms may have affected busulfan pharmacokinetics, but these effects were obscured by other factors, such as underlying disease, systemic conditions, treatment history, and race. Busulfan 49-57 glutathione S-transferase kappa 1 Homo sapiens 13-16 34990437-0 2022 Impact of Glutathione S-transferase Polymorphisms on Busulfan Pharmacokinetics and Outcomes of Hematopoietic Stem Cell Transplantation. Busulfan 53-61 glutathione S-transferase kappa 1 Homo sapiens 10-35 34990437-4 2022 This study aimed to assess the impact of glutathione S-transferase (GST) genetic polymorphisms on the clearance of Bu and the clinical outcomes of patients undergoing HSCT. Busulfan 115-117 glutathione S-transferase kappa 1 Homo sapiens 41-66 34990437-4 2022 This study aimed to assess the impact of glutathione S-transferase (GST) genetic polymorphisms on the clearance of Bu and the clinical outcomes of patients undergoing HSCT. Busulfan 115-117 glutathione S-transferase kappa 1 Homo sapiens 68-71 34990437-7 2022 Each GST polymorphism was analyzed for its impact on busulfan clearance and HSCT outcomes. Busulfan 53-61 glutathione S-transferase kappa 1 Homo sapiens 5-8 33384597-3 2020 BU exposure, involved in the glutathione- (GSH-) glutathione S-transferases (GSTs) pathway and proinflammatory response, is associated with clinical outcomes after HSCT. Busulfan 0-2 glutathione S-transferase kappa 1 Homo sapiens 49-75 33384597-3 2020 BU exposure, involved in the glutathione- (GSH-) glutathione S-transferases (GSTs) pathway and proinflammatory response, is associated with clinical outcomes after HSCT. Busulfan 0-2 glutathione S-transferase kappa 1 Homo sapiens 77-81 26691424-5 2016 Since Bu is mainly metabolized by glutathione S-transferase (GST), we investigated the relationship of GSTA1 and GSTM1 genotypes with first-dose PK and HSCT outcomes in 44 children with thalassemia intermedia and thalassemia major. Busulfan 6-8 glutathione S-transferase kappa 1 Homo sapiens 34-59 26691424-5 2016 Since Bu is mainly metabolized by glutathione S-transferase (GST), we investigated the relationship of GSTA1 and GSTM1 genotypes with first-dose PK and HSCT outcomes in 44 children with thalassemia intermedia and thalassemia major. Busulfan 6-8 glutathione S-transferase kappa 1 Homo sapiens 61-64 25730183-1 2015 BU-based conditioning regimen before allogeneic hematopoietic SCT: a study of influence of GST gene polymorphisms on BU pharmacokinetics and clinical outcomes in Chinese patients. Busulfan 0-2 glutathione S-transferase kappa 1 Homo sapiens 91-94 23292236-3 2013 As BU is mainly metabolized by glutathione S-transferase (GST), we investigated the relationship between GSTA1, GSTM1 and GSTP1 genotypes with first-dose BU PKs, and the relationship with HSCT outcomes in 69 children receiving myeloablative conditioning regimen. Busulfan 3-5 glutathione S-transferase kappa 1 Homo sapiens 31-56 23292236-3 2013 As BU is mainly metabolized by glutathione S-transferase (GST), we investigated the relationship between GSTA1, GSTM1 and GSTP1 genotypes with first-dose BU PKs, and the relationship with HSCT outcomes in 69 children receiving myeloablative conditioning regimen. Busulfan 3-5 glutathione S-transferase kappa 1 Homo sapiens 58-61 19611402-10 2009 One such strategy currently being evaluated is if busulfan clearance can be accurately predicted by genetic polymorphism of glutathione S-transferase (GST), with the currently available data suggesting that GST polymorphisms cannot be used to personalize busulfan dosing. Busulfan 50-58 glutathione S-transferase kappa 1 Homo sapiens 151-154 21135089-2 2011 Using the candidate gene approach, the authors evaluated whether busulfan clearance was associated with polymorphisms in the genes regulating the predominant metabolizing enzymes involved in busulfan conjugation, specifically glutathione S-transferase (GST) isoenzymes A1 (GSTA1) and M1 (GSTM1). Busulfan 65-73 glutathione S-transferase kappa 1 Homo sapiens 226-251 21135089-2 2011 Using the candidate gene approach, the authors evaluated whether busulfan clearance was associated with polymorphisms in the genes regulating the predominant metabolizing enzymes involved in busulfan conjugation, specifically glutathione S-transferase (GST) isoenzymes A1 (GSTA1) and M1 (GSTM1). Busulfan 65-73 glutathione S-transferase kappa 1 Homo sapiens 253-256 21135089-2 2011 Using the candidate gene approach, the authors evaluated whether busulfan clearance was associated with polymorphisms in the genes regulating the predominant metabolizing enzymes involved in busulfan conjugation, specifically glutathione S-transferase (GST) isoenzymes A1 (GSTA1) and M1 (GSTM1). Busulfan 191-199 glutathione S-transferase kappa 1 Homo sapiens 253-256 23252950-4 2013 Moreover, glutathione-S-transferase isoenzymes have been associated with cellular outward transport of various alkylating agents, including Cy metabolites, melphalan, Bu and chlorambucil. Busulfan 167-169 glutathione S-transferase kappa 1 Homo sapiens 10-35 22047155-2 2011 Genetic polymorphisms of glutathione S-transferase (GST), which is involved in the metabolism of busulfan, have been implicated in interindividual variability in busulfan pharmacokinetics. Busulfan 97-105 glutathione S-transferase kappa 1 Homo sapiens 25-50 22047155-2 2011 Genetic polymorphisms of glutathione S-transferase (GST), which is involved in the metabolism of busulfan, have been implicated in interindividual variability in busulfan pharmacokinetics. Busulfan 97-105 glutathione S-transferase kappa 1 Homo sapiens 52-55 22047155-2 2011 Genetic polymorphisms of glutathione S-transferase (GST), which is involved in the metabolism of busulfan, have been implicated in interindividual variability in busulfan pharmacokinetics. Busulfan 162-170 glutathione S-transferase kappa 1 Homo sapiens 25-50 22047155-2 2011 Genetic polymorphisms of glutathione S-transferase (GST), which is involved in the metabolism of busulfan, have been implicated in interindividual variability in busulfan pharmacokinetics. Busulfan 162-170 glutathione S-transferase kappa 1 Homo sapiens 52-55 22047155-3 2011 Development of a rapid and simplified method for polygenic analysis of GST may facilitate large pharmacogenetic studies and clinical application of individualized busulfan dose adjustment. Busulfan 163-171 glutathione S-transferase kappa 1 Homo sapiens 71-74 22047155-5 2011 OBJECTIVE: The aim of this study was to extend the application of the TotalPlex method to the specific GST gene families (A1, P1, M1, and T1) that are related to busulfan metabolism, and thereby facilitate pharmacogenetic analysis of GST polymorphisms. Busulfan 162-170 glutathione S-transferase kappa 1 Homo sapiens 103-106 22047155-5 2011 OBJECTIVE: The aim of this study was to extend the application of the TotalPlex method to the specific GST gene families (A1, P1, M1, and T1) that are related to busulfan metabolism, and thereby facilitate pharmacogenetic analysis of GST polymorphisms. Busulfan 162-170 glutathione S-transferase kappa 1 Homo sapiens 234-237 19584821-0 2010 Influence of GST gene polymorphisms on busulfan pharmacokinetics in children. Busulfan 39-47 glutathione S-transferase kappa 1 Homo sapiens 13-16 19584821-3 2010 As BU is mainly metabolized by glutathione S-transferase (GST), it is hypothesized that functional polymorphisms in GST genes may explain in part the variability in BU pharmacokinetics. Busulfan 3-5 glutathione S-transferase kappa 1 Homo sapiens 31-56 19584821-3 2010 As BU is mainly metabolized by glutathione S-transferase (GST), it is hypothesized that functional polymorphisms in GST genes may explain in part the variability in BU pharmacokinetics. Busulfan 3-5 glutathione S-transferase kappa 1 Homo sapiens 58-61 19584821-3 2010 As BU is mainly metabolized by glutathione S-transferase (GST), it is hypothesized that functional polymorphisms in GST genes may explain in part the variability in BU pharmacokinetics. Busulfan 3-5 glutathione S-transferase kappa 1 Homo sapiens 116-119