PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15142875-6 2004 We conclude that the GSTM1-null genotype predisposes to HVOD, and the sinusoidal endothelial cells and hepatocyte damage may be mediated by metabolites of busulfan through depletion of the cellular GSH pool. Busulfan 155-163 glutathione S-transferase mu 1 Homo sapiens 21-26 8886613-2 1996 We have characterized the busulfan-conjugating activity of purified human liver GSTA1-1, GSTA1-2, GSTA2-2, GSTM1-1, and placental GSTP1-1. Busulfan 26-34 glutathione S-transferase mu 1 Homo sapiens 107-114 30511436-5 2019 GSTA1*B and GSTM1 null genotypes significantly decreased CLIV of busulfan (standardized difference in means (SDM) = -1.103; P = 0.019 and SDM = -0.418; P = 0.002, respectively). Busulfan 65-73 glutathione S-transferase mu 1 Homo sapiens 12-17 31834435-1 2020 PURPOSE: This study aimed to develop a population pharmacokinetic (PPK) model to investigate the impact of GSTA1, GSTP1, and GSTM1 genotypes on busulfan pharmacokinetic (PK) variability in Chinese adult patients. Busulfan 144-152 glutathione S-transferase mu 1 Homo sapiens 125-130 31555969-10 2020 These results suggest that a GSTM1-positive genotype in patients receiving BU/CY conditioning protects against relapse of hematological malignancies after allogeneic hematopoietic stem cell transplantation. Busulfan 75-77 glutathione S-transferase mu 1 Homo sapiens 29-34 34499222-1 2022 PURPOSE: This study aimed to retrospectively evaluate the genetic association of null variants of glutathione S-transferases GSTM1 and GSTT1 with relapse incidence in children with hematological malignancies (HMs) undergoing busulfan (BU)- containing allogeneic hematopoietic stem cell transplantation (HSCT) and to assess the impact of these variants on BU-induced cytotoxicity on the immortalized lymphoblastoid cell lines (LCLs) and tumor THP1 GST gene-edited cell models. Busulfan 225-233 glutathione S-transferase mu 1 Homo sapiens 125-130 34499222-1 2022 PURPOSE: This study aimed to retrospectively evaluate the genetic association of null variants of glutathione S-transferases GSTM1 and GSTT1 with relapse incidence in children with hematological malignancies (HMs) undergoing busulfan (BU)- containing allogeneic hematopoietic stem cell transplantation (HSCT) and to assess the impact of these variants on BU-induced cytotoxicity on the immortalized lymphoblastoid cell lines (LCLs) and tumor THP1 GST gene-edited cell models. Busulfan 235-237 glutathione S-transferase mu 1 Homo sapiens 125-130 34499222-1 2022 PURPOSE: This study aimed to retrospectively evaluate the genetic association of null variants of glutathione S-transferases GSTM1 and GSTT1 with relapse incidence in children with hematological malignancies (HMs) undergoing busulfan (BU)- containing allogeneic hematopoietic stem cell transplantation (HSCT) and to assess the impact of these variants on BU-induced cytotoxicity on the immortalized lymphoblastoid cell lines (LCLs) and tumor THP1 GST gene-edited cell models. Busulfan 355-357 glutathione S-transferase mu 1 Homo sapiens 125-130 34499222-6 2022 BU-induced cell death preferentially in THP1GSTM1(non-null) and LCLsGSTM1(non-null) as shown by decreased viability, increased necrosis and levels of the oxidized form of glutathione compared to null cells, while GSTT1 non-null cells showed increased baseline proliferation. Busulfan 0-2 glutathione S-transferase mu 1 Homo sapiens 64-73 34499222-8 2022 Functional studies have indicated that GSTM1 status modulates BU-induced cell death. Busulfan 62-64 glutathione S-transferase mu 1 Homo sapiens 39-44 30511436-9 2019 GSTA1 and GSTM1 genotypes affected CLIV of busulfan, but only GSTA1 affected AUCIV . Busulfan 43-51 glutathione S-transferase mu 1 Homo sapiens 10-15 21215809-8 2011 A trend test analyzing the overall effect of GST genotype on busulfan pharmacokinetics, combining GSTA1 gene polymorphism and the number of GSTM1- and GSTT-null genotypes, showed a significant correlation between GST genotype and busulfan clearance (P = .001). Busulfan 61-69 glutathione S-transferase mu 1 Homo sapiens 140-145 28744217-14 2017 Article summary: (1) Children carrying functional alleles in GSTM1 and CYP2C9 are at high risk for developing hemorrhagic cystitis following treatment with busulfan and cyclophosphamide based conditioning regimen. Busulfan 156-164 glutathione S-transferase mu 1 Homo sapiens 61-66 18635758-3 2008 GSTA1, GSTP1, and GSTM1 variants were explored for their effects on busulfan exposures. Busulfan 68-76 glutathione S-transferase mu 1 Homo sapiens 18-23 18641537-3 2008 In this report, the contribution of genetic polymorphisms in the glutathione-S-transferases (GST) isozymes GSTA1, GSTM1, GSTP1, and GSTT1 to the pharmacokinetics of busulfan is studied retrospectively. Busulfan 165-173 glutathione S-transferase mu 1 Homo sapiens 114-119